Nampt-IN-9

• 常用名: Nampt-IN-9
• 英文名: Nampt-IN-9
• CAS号: 2180973-35-5
• 分子量: 451.56
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₆H₃₃N₃O₄
• 熔点: N/A
• 闪点: N/A

Nampt-IN-9用途

Nampt-IN-9(化合物8)是一种具有抗癌活性的有效Nampt抑制剂。Nampt-IN-9可用于胰腺导管腺癌的研究[1]。

Nampt-IN-9名称

• 英文名: Nampt-IN-9

Nampt-IN-9生物活性

• 描述: Nampt-IN-9(化合物8)是一种具有抗癌活性的有效Nampt抑制剂。Nampt-IN-9可用于胰腺导管腺癌的研究[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 代谢酶/蛋白酶 >> NAMPT
• 体外研究: Nampt-IN-9(化合物8)显示出抗增殖活性,IC50值分别为0.8、0.5、0.004和0.6nM,对Jurkat、MIA PaCa-2、BxPC-3和PANC-1细胞[1]。Nampt-IN-9(0-1μM)钝化Jurkat白血病细胞中的NAD+和ATP水平并激活半胱天冬酶3[1]。
• 参考文献:

  [1]. Bai JF, et al. Identification of new FK866 analogues with potent anticancer activity against pancreatic cancer. Eur J Med Chem. 2022 Jun 2;239:114504.

Nampt-IN-9物理化学性质

• 分子式: C₂₆H₃₃N₃O₄
• 分子量: 451.56

Nampt-IN-9靶点实验

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实验名称：Induction of apoptosis in human Jurkat cells assessed as cell death at upto 1000 nM m... 来源：ChEMBL 靶标：Jurkat External Id：CHEMBL5352595

实验名称：Induction of apoptosis in human Jurkat cells assessed as caspase-3 cleavage at 10 nM ... 来源：ChEMBL 靶标：Jurkat External Id：CHEMBL5352596

实验名称：Antiproliferative activity against human Jurkat cells assessed as reduction in cell v... 来源：ChEMBL 靶标：Jurkat External Id：CHEMBL5352593

实验名称：Antiproliferative activity against human Jurkat cells assessed as reduction in cell v... 来源：ChEMBL 靶标：Jurkat External Id：CHEMBL5352594

实验名称：Antiproliferative activity against human PANC-1 cells assessed as inhibition of cell ... 来源：ChEMBL 靶标：PANC-1 External Id：CHEMBL5352591

实验名称：Inhibition of NAMPT in human Jurkat cells assessed as reduction in intracellular NAD+... 来源：ChEMBL 靶标：Nicotinamide phosphoribosyltransferase External Id：CHEMBL5352592

实验名称：Antiproliferative activity against human MIA PaCa-2 cells assessed as inhibition of c... 来源：ChEMBL 靶标：MIA PaCa-2 External Id：CHEMBL5352589

实验名称：Antiproliferative activity against human BXPC-3 cells assessed as inhibition of cell ... 来源：ChEMBL 靶标：BXPC-3 External Id：CHEMBL5352590

实验名称：Inhibition of NAMPT in human Jurkat cells assessed as depletion in intracellular ATP ... 来源：ChEMBL 靶标：Nicotinamide phosphoribosyltransferase External Id：CHEMBL5352587

实验名称：Antiproliferative activity against human Jurkat cells assessed as inhibition of cell ... 来源：ChEMBL 靶标：Jurkat External Id：CHEMBL5352588

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