3'-甲氧基大豆黄素

• 常用名: 3'-甲氧基大豆黄素
• 英文名: 3'-Methoxydaidzein
• CAS号: 21913-98-4
• 分子量: 284.26
• 密度: 1.4±0.1 g/cm3
• 沸点: 534.5±50.0 °C at 760 mmHg
• 分子式: C₁₆H₁₂O₅
• 熔点: 258-260℃
• 闪点: 204.8±23.6 °C

3'-甲氧基大豆黄素用途

3'-甲氧基大豆黄酮是一种异黄酮和钠通道抑制剂。3'-甲氧基大豆黄酮抑制亚型NaV1.7、NaV1.8和NaV1.3,IC50分别为181 nM、397 nM和505 nM。3'-甲氧基大豆黄酮通过抑制电压门控钠通道发挥镇痛活性[1]。

3'-甲氧基大豆黄素名称

• 中文名: 7,4'-二羟基-3'-甲氧基异黄酮
• 英文名: 7,4'-dihydroxy-3'-methoxyisoflavone

3'-甲氧基大豆黄素生物活性

• 描述: 3'-甲氧基大豆黄酮是一种异黄酮和钠通道抑制剂。3'-甲氧基大豆黄酮抑制亚型NaV1.7、NaV1.8和NaV1.3,IC50分别为181 nM、397 nM和505 nM。3'-甲氧基大豆黄酮通过抑制电压门控钠通道发挥镇痛活性[1]。
• 相关类别:
  信号通路 >> 跨膜转运 >> 钠通道
  研究领域 >> 神经疾病
• 靶点实验:

  Nav1.3:505 nM (IC50)

  Nav1.7:181 nM (IC50)

  Nav1.8:397 nM (IC50)

• 参考文献:

  [1]. Xu RJ, et al. 3'-Methoxydaidzein exerts analgesic activity by inhibiting voltage-gated sodium channels. Chin J Nat Med. 2019 Jun;17(6):413-423.

3'-甲氧基大豆黄素物理化学性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 534.5±50.0 °C at 760 mmHg
• 熔点: 258-260℃
• 分子式: C₁₆H₁₂O₅
• 分子量: 284.26
• 闪点: 204.8±23.6 °C
• 精确质量: 284.068481
• PSA: 79.90000
• LogP: 2.54
• InChIKey: MUYAUELJBWQNDH-UHFFFAOYSA-N
• SMILES: COc1cc(-c2coc3cc(O)ccc3c2=O)ccc1O
• 外观性状: 粉末
• 蒸汽压: 0.0±1.5 mmHg at 25°C
• 折射率: 1.669
• 储存条件: 室温

3'-甲氧基大豆黄素安全信息

• 危害码 (欧洲): Xi
• 海关编码: 2914509090

3'-甲氧基大豆黄素海关

• 海关编码: 2914509090
• 中文概述: 2914509090 含其他含氧基的酮. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:5.5% 普通关税:30.0%
• 申报要素: 品名, 成分含量, 用途, 丙酮报明包装
• Summary: HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

3'-甲氧基大豆黄素靶点实验

查看更多实验

实验名称：Estrogenic activity in human T47D cells assessed as drug level causing stimulation of... 来源：ChEMBL 靶标：T47D External Id：CHEMBL1104030

实验名称：Antioxidant activity assessed as DPPH radical scavenging activity 来源：ChEMBL 靶标：N/A External Id：CHEMBL1291750

实验名称：Activation of Nrf2 (unknown origin) expressed in human HepG2 cells at 10 uM incubated... 来源：ChEMBL 靶标：Nuclear factor erythroid 2-related factor 2 External Id：CHEMBL4046717

实验名称：Estrogenic activity in luciferase transfected human T47D cells assessed as drug level... 来源：ChEMBL 靶标：T47D External Id：CHEMBL1104037

实验名称：Estrogenic activity in luciferase transfected human T47D cells assessed as drug level... 来源：ChEMBL 靶标：T47D External Id：CHEMBL1104036

实验名称：Antiproliferative activity against estrogen receptor expressing human MDA-MB-436 cell... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL1112224

实验名称：Estrogenic activity in luciferase transfected human MCF7 cells assessed as drug level... 来源：ChEMBL 靶标：MCF7 External Id：CHEMBL1104035

实验名称：Antiproliferative activity against estrogen receptor expressing human MCF7 cells 来源：ChEMBL 靶标：MCF7 External Id：CHEMBL1112223

实验名称：Estrogenic activity in luciferase transfected human MCF7 cells assessed as drug level... 来源：ChEMBL 靶标：MCF7 External Id：CHEMBL1104034

实验名称：Estrogenic activity in human MCF7 cells assessed as drug level causing stimulation of... 来源：ChEMBL 靶标：MCF7 External Id：CHEMBL1104033

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3'-甲氧基大豆黄素英文别名

• Isoflavone,4',7-dihydroxy-3'-methoxy
• 3'-Methoxydaidzein
• 7-hydroxy-3-(4-hydroxy-3-methoxyphenyl)chromen-4-one
• 4',7-dihydroxy-3'-methoxyisoflavone
• 7,4'-dihydroxy-3'-methoxy-isoflavone
• 7-Hydroxy-3-(4-hydroxy-3-methoxyphenyl)-4H-chromen-4-one