3'-Methoxydaidzein

Modify Date: 2024-01-02 18:08:58

3'-Methoxydaidzein Structure
3'-Methoxydaidzein structure
Common Name 3'-Methoxydaidzein
CAS Number 21913-98-4 Molecular Weight 284.26
Density 1.4±0.1 g/cm3 Boiling Point 534.5±50.0 °C at 760 mmHg
Molecular Formula C16H12O5 Melting Point 258-260℃
MSDS N/A Flash Point 204.8±23.6 °C

 Use of 3'-Methoxydaidzein


3'-Methoxydaidzein is a isoflavone and a Sodium Channel inhibitor. 3'-Methoxydaidzein inhibits subtypes NaV1.7, NaV1.8 and NaV1.3 with IC50 of 181 nM, 397 nM, and 505 nM, respectively. 3'-Methoxydaidzein exerts analgesic activity by inhibiting voltage-gated sodium channels[1].

 Names

Name 7,4'-dihydroxy-3'-methoxyisoflavone
Synonym More Synonyms

 3'-Methoxydaidzein Biological Activity

Description 3'-Methoxydaidzein is a isoflavone and a Sodium Channel inhibitor. 3'-Methoxydaidzein inhibits subtypes NaV1.7, NaV1.8 and NaV1.3 with IC50 of 181 nM, 397 nM, and 505 nM, respectively. 3'-Methoxydaidzein exerts analgesic activity by inhibiting voltage-gated sodium channels[1].
Related Catalog
Target

Nav1.3:505 nM (IC50)

Nav1.7:181 nM (IC50)

Nav1.8:397 nM (IC50)

References

[1]. Xu RJ, et al. 3'-Methoxydaidzein exerts analgesic activity by inhibiting voltage-gated sodium channels. Chin J Nat Med. 2019 Jun;17(6):413-423.  

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 534.5±50.0 °C at 760 mmHg
Melting Point 258-260℃
Molecular Formula C16H12O5
Molecular Weight 284.26
Flash Point 204.8±23.6 °C
Exact Mass 284.068481
PSA 79.90000
LogP 2.54
Vapour Pressure 0.0±1.5 mmHg at 25°C
Index of Refraction 1.669

 Safety Information

Hazard Codes Xi
HS Code 2914509090

 Synthetic Route

 Customs

HS Code 2914509090
Summary HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

 Synonyms

Isoflavone,4',7-dihydroxy-3'-methoxy
3'-Methoxydaidzein
7-hydroxy-3-(4-hydroxy-3-methoxyphenyl)chromen-4-one
4H-1-Benzopyran-4-one, 7-hydroxy-3-(4-hydroxy-3-methoxyphenyl)-
4',7-dihydroxy-3'-methoxyisoflavone
7,4'-dihydroxy-3'-methoxy-isoflavone
7-Hydroxy-3-(4-hydroxy-3-methoxyphenyl)-4H-chromen-4-one