DH97

• 常用名: DH97
• 英文名: DH 97
• CAS号: 220339-00-4
• 分子量: 334.455
• 密度: 1.1±0.1 g/cm3
• 沸点: 580.1±38.0 °C at 760 mmHg
• 分子式: C₂₂H₂₆N₂O
• 熔点: N/A
• 闪点: 304.6±26.8 °C

DH97用途

DH97是一种有效的选择性MT2褪黑素受体拮抗剂,人MT2的pKi为8.03。DH97对人MT2的选择性是人mt1和爪蟾mel1c受体亚型的89倍和229倍。DH97可抑制褪黑素诱导的电诱发反应增强[1][2]。

DH97名称

• 英文名: DH97

DH97生物活性

• 描述: DH97是一种有效的选择性MT2褪黑素受体拮抗剂,人MT2的pKi为8.03。DH97对人MT2的选择性是人mt1和爪蟾mel1c受体亚型的89倍和229倍。DH97可抑制褪黑素诱导的电诱发反应增强[1][2]。
• 相关类别:
  信号通路 >> 神经信号通路 >> 褪黑激素受体
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 褪黑激素受体
  研究领域 >> 神经疾病
• 靶点实验:

  MT2:8.03 (pKi)

  MT1:6.08 (pKi)

• 体外研究: DH97(化合物9)(0.1-100μM；2 h)拮抗褪黑素(10 nM)在非洲爪蟾黑色素细胞中诱导的色素聚集[1]。DH97在浓度高达100µM时没有激动剂活性[1]。DH97(60 nM)在低浓度MT2选择性配体下显著改变大鼠尾动脉中褪黑素的效力,pEC50为8.83[2]。DH97(5 μM)导致褪黑素的血管收缩作用在浓度对mt1和MT2受体无选择性时显著向右移位[2]。
• 参考文献:

  [1]. Teh MT, et, al. Comparison of the structure-activity relationships of melatonin receptor agonists and antagonists: lengthening the N-acyl side-chain has differing effects on potency on Xenopus melanophores. Naunyn Schmiedebergs Arch Pharmacol. 1998 Nov;358(5):522-8.

  [2]. Ting KN, et, al. Molecular and pharmacological evidence for MT1 melatonin receptor subtype in the tail artery of juvenile Wistar rats. Br J Pharmacol. 1999 Jun;127(4):987-95.

DH97物理化学性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 580.1±38.0 °C at 760 mmHg
• 分子式: C₂₂H₂₆N₂O
• 分子量: 334.455
• 闪点: 304.6±26.8 °C
• 精确质量: 334.204498
• LogP: 4.63
• InChIKey: HDOIPCLEKCEANF-UHFFFAOYSA-N
• SMILES: CCCCC(=O)NCCc1c(Cc2ccccc2)[nH]c2ccccc12
• 蒸汽压: 0.0±1.6 mmHg at 25°C
• 折射率: 1.605

DH97靶点实验

查看更多实验

实验名称：Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident pro... 来源：NCGC 靶标：N/A External Id：SERCaMPGLuc-p1-antagonist

实验名称：qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in... 来源：NCGC 靶标：TDP1 protein [Homo sapiens] External Id：TDP1100

实验名称：qHTS for Stage-Specific Inhibitors of Vaccinia Orthopoxvirus: mCherry Reporter Primar... 来源：NCGC 靶标：67.9K protein [Vaccinia virus] External Id：Vaccinia-p2mCherry

实验名称：qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in... 来源：NCGC 靶标：TDP1 protein [Homo sapiens] External Id：TDP1101

实验名称：Rescue cell viability in cybrid cells with a genetic mutation in complex 1 of the mit... 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：N/A External Id：HMS1315

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL4495582

实验名称：Tocris HTS for Inhibitors of Aerobactin Synthetase lucA 来源：23265 External Id：IucA Pilot Assay Tocris Library

实验名称：qHTS for Stage-Specific Inhibitors of Vaccinia Orthopoxvirus: Venus Reporter Primary ... 来源：NCGC 靶标：67.9K protein [Vaccinia virus] External Id：Vaccinia-p2Venus

实验名称：qHTS for inhibitors of Vif-A3G interactions: Validation 来源：NCGC 靶标：DNA dC->dU-editing enzyme APOBEC-3G [Homo sapiens] External Id：VIFG001

实验名称：Primary Screen Inhibitors of CD40 Signaling in BL2 Cells Measured in Cell-Based Syste... 来源：Broad Institute 靶标：N/A External Id：7124-01_Inhibitor_SinglePoint_HTS_Activity

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DH97英文别名

• N-(2-(2-Benzyl-1H-indol-3-yl)ethyl)pentanamide
• N-[2-(2-Benzyl-1H-indol-3-yl)ethyl]pentanamide
• DH97
• MFCD02262121