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瑞他莫林

瑞他莫林用途

Retapamulin(SB-275833)是局部抗生素,能结合金黄色葡萄球菌和大肠杆菌核糖体,Kd为3 nM。

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瑞他莫林名称

[ CAS 号 ]:
224452-66-8

[ 中文名 ]:
瑞他莫林

[ 英文名 ]:
Retapamulin

[中文别名 ]:

瑞他帕林

[英文别名 ]:

Rebapamulin
Altabax
Altargo
MFCD11045316
Retapamulin

瑞他莫林生物活性

[ 描述 ]:

Retapamulin(SB-275833)是局部抗生素,能结合金黄色葡萄球菌和大肠杆菌核糖体,Kd为3 nM。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 细菌

研究领域 >> 其他

[参考文献]

[1]. Kircik LH. Efficacy and tolerability of retapamulin 1% ointment for the treatment of infected atopic dermatitis: a pilot study. J Drugs Dermatol. 2012 Jul 1;11(7):858-60.

[2]. Candel FJ, Morales G, Picazo JJ. In vitro activity of retapamulin against linezolid and methicillin-resistant Staphylococcus aureus isolates. Rev Esp Quimioter. 2011 Sep;24(3):127-30.

[3]. Pérez-Trallero E, Tamayo E, Montes M, García-Arenzana JM, Iriarte V. In vitro activities of retapamulin and 16 other antimicrobial agents against recently obtained Streptococcus pyogenes isolates. Antimicrob Agents Chemother. 2011 May;55(5):2406-8.

[4]. Weinberg JM, Tyring SK. Retapamulin: an antibacterial with a novel mode of action in an age of emerging resistance to Staphylococcus aureus. J Drugs Dermatol. 2010 Oct;9(10):1198-204.

[5]. Retapamulin: focus on its use in the treatment of uncomplicated superficial skin infections and impetigo By Jacobs, Michael R.From Expert Review of Dermatology (2010), 5(5), 505-517.

[相关活性小分子]

瑞他莫林物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
594.9±50.0 °C at 760 mmHg

[ 分子式 ]:
C₃₀H₄₇NO₄S

[ 分子量 ]:
517.763

[ 闪点 ]:
313.6±30.1 °C

[ 精确质量 ]:
517.322571

[ PSA ]:
92.14000

[ LogP ]:
5.45

[ 蒸汽压 ]:
0.0±3.8 mmHg at 25°C

[ 折射率 ]:
1.571

[ 储存条件 ]:
2~8℃

瑞他莫林安全信息

[ 危害码 (欧洲) ]:
Xi

[ 海关编码 ]:
2933990090

瑞他莫林合成路线

详细合成路线

瑞他莫林上下游产品

瑞他莫林上游产品

瑞他莫林下游产品

瑞他莫林海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%