RTS-V5

• 常用名: RTS-V5
• 英文名: RTS-V5
• CAS号: 2285346-31-6
• 分子量: 525.60
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₇H₃₅N₅O₆
• 熔点: N/A
• 闪点: N/A

RTS-V5用途

RTS-V5是HDAC/蛋白酶体的抑制剂,对HDAC1,HDAC2,HDAC3,HDAC6,HDAC8的IC50分别为6.9,18,15,0.27,0.53 μM。

RTS-V5名称

• 中文名: RTS-V5
• 英文名: RTS-V5

RTS-V5生物活性

• 描述: RTS-V5是HDAC/蛋白酶体的抑制剂,对HDAC1,HDAC2,HDAC3,HDAC6,HDAC8的IC50分别为6.9,18,15,0.27,0.53 μM。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 细胞周期/DNA损伤 >> HDAC
  信号通路 >> 代谢酶/蛋白酶 >> 蛋白酶体
  信号通路 >> 表观遗传学 >> HDAC
• 靶点实验:

  IC50: 6.9 nM (HDAC1), 18 nM (HDAC2), 15 nM (HDAC3), 0.27 nM (HDAC6), 0.53 nM (HDAC8)[1]

• 参考文献:

  [1]. Bhatia S, et al. Discovery of the First-in-Class Dual Histone Deacetylase-Proteasome Inhibitor. J Med Chem. 2018 Nov 21;61(22):10299-10309.

RTS-V5物理化学性质

• 分子式: C₂₇H₃₅N₅O₆
• 分子量: 525.60

RTS-V5靶点实验

查看更多实验

实验名称：Inhibition of caspase-like activity of 20S proteasome in human SEM cells at 4 nM to 2... 来源：ChEMBL 靶标：Proteasome subunit beta type-1 External Id：CHEMBL4158931

实验名称：Inhibition of caspase-like activity of 20S proteasome in imatinib-resistant human SUP... 来源：ChEMBL 靶标：Proteasome subunit beta type-1 External Id：CHEMBL4158932

实验名称：Inhibition of trypsin-like activity of 20S proteasome in human HL60 cells at 4 nM to ... 来源：ChEMBL 靶标：Proteasome subunit beta type-2 External Id：CHEMBL4158927

实验名称：Inhibition of trypsin-like activity of 20S proteasome in human SEM cells at 4 nM to 2... 来源：ChEMBL 靶标：Proteasome subunit beta type-2 External Id：CHEMBL4158928

实验名称：Inhibition of trypsin-like activity of 20S proteasome in human imatinib-resistant SUP... 来源：ChEMBL 靶标：Proteasome subunit beta type-2 External Id：CHEMBL4158929

实验名称：Inhibition of caspase-like activity of 20S proteasome in human HL60 cells at 4 nM to ... 来源：ChEMBL 靶标：Proteasome subunit beta type-1 External Id：CHEMBL4158930

实验名称：Inhibition of HDAC6 in human HL60 cells assessed as increase in acetyl-alpha tubulin ... 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4158909

实验名称：Inhibition of HDAC6 in human SEM cells assessed as increase in acetyl-alpha tubulin e... 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4158910

实验名称：Inhibition of HDAC6/chymotrypsin-like activity of 20S proteasome in human SEM cells a... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4158968

实验名称：Inhibition of HDAC6/chymotrypsin-like activity of 20S proteasome in human HL60 cells ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4158915

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