Tubulin polymerization-IN-16

• 常用名: Tubulin polymerization-IN-16
• 英文名: Tubulin polymerization-IN-16
• CAS号: 2296731-38-7
• 分子量: 465.50
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₄H₂₇N₅O₅
• 熔点: N/A
• 闪点: N/A

Tubulin polymerization-IN-16用途

微管蛋白聚合-IN-16(化合物5g)是一种有效的微管蛋白聚合抑制剂。微管蛋白聚合-IN-16显示出对癌细胞最有效的IC50值为0.084-0.221μM。微管蛋白聚合-IN-16可能破坏微管/微管蛋白动力学,诱导SGC-7901细胞G2/M期细胞周期停滞【1】。

Tubulin polymerization-IN-16名称

• 英文名: Tubulin polymerization-IN-16

Tubulin polymerization-IN-16生物活性

• 描述: 微管蛋白聚合-IN-16(化合物5g)是一种有效的微管蛋白聚合抑制剂。微管蛋白聚合-IN-16显示出对癌细胞最有效的IC50值为0.084-0.221μM。微管蛋白聚合-IN-16可能破坏微管/微管蛋白动力学,诱导SGC-7901细胞G2/M期细胞周期停滞【1】。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 细胞周期/DNA损伤 >> 微管/微管蛋白
  信号通路 >> 细胞骨架 >> 微管/微管蛋白
• 参考文献:

  [1]. Huang L, et al. Design, synthesis and bio-evaluation of novel 2-aryl-4-(3,4,5-trimethoxy-benzoyl)-5-substituted-1,2,3-triazoles as the tubulin polymerization inhibitors. Eur J Med Chem. 2020;186:111846.

Tubulin polymerization-IN-16物理化学性质

• 分子式: C₂₄H₂₇N₅O₅
• 分子量: 465.50

Tubulin polymerization-IN-16靶点实验

查看更多实验

实验名称：Cell cycle arrest in human SGC-7901 cells assessed as increase in G2/M cell populatio... 来源：ChEMBL 靶标：SGC-7901 External Id：CHEMBL4722482

实验名称：Antiproliferative activity against human HeLa cells assessed as inhibition of cell gr... 来源：ChEMBL 靶标：HeLa External Id：CHEMBL4722480

实验名称：Cell cycle arrest in human SGC-7901 cells assessed as decrease in G1 cell population ... 来源：ChEMBL 靶标：SGC-7901 External Id：CHEMBL4722481

实验名称：Cell cycle arrest in human SGC-7901 cells assessed as increase in sub-G1 cell populat... 来源：ChEMBL 靶标：SGC-7901 External Id：CHEMBL4722486

实验名称：Cell cycle arrest in human SGC-7901 cells assessed as accumulation at G2/M cell popul... 来源：ChEMBL 靶标：SGC-7901 External Id：CHEMBL4722485

实验名称：Induction of microtubule disruption in human SGC-7901 cells assessed as appearance of... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4722490

实验名称：Induction of microtubule disruption in human SGC-7901 cells assessed as shrinkage of ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4722491

实验名称：Induction of microtubule disruption in human SGC-7901 cells assessed as change in sha... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4722489

实验名称：Antiproliferative activity against human SGC-7901 cells assessed as inhibition of cel... 来源：ChEMBL 靶标：SGC-7901 External Id：CHEMBL4722478

实验名称：Antiproliferative activity against human A549 cells assessed as inhibition of cell gr... 来源：ChEMBL 靶标：A549 External Id：CHEMBL4722479

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