阿扎那韦硫酸盐

• 常用名: 阿扎那韦硫酸盐
• 英文名: Atazanavir sulfate
• CAS号: 229975-97-7
• 分子量: 802.934
• 密度: 1.164g/cm3
• 沸点: 995.5ºC at 760 mmHg
• 分子式: C₃₈H₅₄N₆O₁₁S
• 熔点: 195.0°, or acetone; mp 198-199° (dec)
• 闪点: 555.8ºC
• 符号: GHS05, GHS08
• 信号词: Danger

阿扎那韦硫酸盐用途

Atazanavir硫酸盐是HIV-1蛋白酶高活性抑制剂。

阿扎那韦硫酸盐名称

• 中文名: 阿扎那韦硫酸盐
• 英文名: atazanavir sulfate
• 中文别名: 硫酸阿扎那韦 | 西洛司特 | 阿扎那韦硫酸盐

阿扎那韦硫酸盐生物活性

• 描述: Atazanavir硫酸盐是HIV-1蛋白酶高活性抑制剂。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> HIV蛋白酶
  信号通路 >> 抗感染 >> HIV
  研究领域 >> 感染
• 参考文献:

  [1]. Piliero PJ. Atazanavir: A novel once-daily protease inhibitor. Drugs Today (Barc). 2004 Nov;40(11):901-12.

  [2]. Fukushima K, et al. Effect of serum lipids on the pharmacokinetics of atazanavir in hyperlipidemic rats. Biomed Pharmacother. 2009 Nov;63(9):635-42.

阿扎那韦硫酸盐物理化学性质

• 密度: 1.164g/cm3
• 沸点: 995.5ºC at 760 mmHg
• 熔点: 195.0°, or acetone; mp 198-199° (dec)
• 分子式: C₃₈H₅₄N₆O₁₁S
• 分子量: 802.934
• 闪点: 555.8ºC
• 精确质量: 802.357117
• PSA: 254.20000
• LogP: 6.20320
• InChIKey: DQSGVVGOPRWTKI-QVFAWCHISA-N
• SMILES: COC(=O)NC(C(=O)NC(Cc1ccccc1)C(O)CN(Cc1ccc(-c2ccccn2)cc1)NC(=O)C(NC(=O)OC)C(C)(C)C)C(C)(C)C.O=S(=O)(O)O
• 外观性状: 固体;White to Almost white powder to crystal
• 蒸汽压: 0mmHg at 25°C
• 储存条件: <0°C;存放于惰性气体之中;避免空气,加热

阿扎那韦硫酸盐安全信息

• 符号: GHS05, GHS08
• 信号词: Danger
• 危害声明: H318-H372
• 警示性声明: P260-P280-P305 + P351 + P338 + P310
• 靶器官: Heart, Liver
• 危害码 (欧洲): Xi
• 安全声明 (欧洲): 24/25
• 危险品运输编码: NONH for all modes of transport

阿扎那韦硫酸盐靶点实验

查看更多实验

实验名称：Fluorescence-based biochemical high throughput primary assay to identify inhibitors o... 来源：The Scripps Research Institute Molecular Screening Center 靶标：Trypanosoma brucei RNA editing ligase 1 External Id：TBREL1_INH_FRET_1536_1X%INH PRUN

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Counterscreen for inhibitors of 5-meCpG-binding domain protein 2 (MBD2): TRFRET-based... 来源：The Scripps Research Institute Molecular Screening Center 靶标：E3 ubiquitin-protein ligase UHRF1 isoform 1 [Homo sapiens] External Id：UHRF1-CPGDNA_INH_TRFRET_1536_1X%INH CSRUN for MBD2-CPGDNA INH

实验名称：Luminescence-based cell-based primary high throughput screening assay for inhibitors ... 来源：The Scripps Research Institute Molecular Screening Center 靶标：nuclear receptor subfamily 0 group B member 1 [Homo sapiens] External Id：DAX1-FULL_INH_LUMI_1536_1X%INH PRUN

实验名称：uHTS identification of small molecule modulators of Rev-erb Alpha. 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：SBCCG-A1016-RevErbaLBD-Primary-Assay

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VER... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4513082

实验名称：Fluorescence-based biochemical high throughput primary assay to identify inhibitors o... 来源：The Scripps Research Institute Molecular Screening Center 靶标：Phospholipase C, beta 3 (phosphatidylinositol-specific) [Homo sapiens] External Id：PLCB3_INH_QFRET_1536_1X%INH PRUN

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Cac... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4303805

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：ADAM10 [Homo sapiens] External Id：ADAM10_INH_QFRET_1536_1X%INH PRUN

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：Protein DAF-12, isoform a [Caenorhabditis elegans] External Id：HGDAF12_AG_LUMI_1536_1X%ACT PRUN

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阿扎那韦硫酸盐英文别名

• Zrivada {Sulfate}
• methyl [(1S,4S,5S,10S)-4-benzyl-1,10-di-tert-butyl-5-hydroxy-2,9,12-trioxo-7-(4-pyridin-2-ylbenzyl)-13-oxa-3,7,8,11-tetraazatetradec-1-yl]carbamate sulfate (salt)
• BMS-232632-05 {Sulfate}
• Methyl {(5S,10S,11S,14S)-11-benzyl-10-hydroxy-15,15-dimethyl-5-(2-methyl-2-propanyl)-3,6,13-trioxo-8-[4-(2-pyridinyl)benzyl]-2-oxa-4,7,8,12-tetraazahexadecan-14-yl}carbamate sulfate (1:1) (non-preferred name)
• Butanoic acid, 2-[(methoxycarbonyl)amino]-3,3-dimethyl-, 2-[(2S,3S)-2-hydroxy-3-[[(2S)-2-[(methoxycarbonyl)amino]-3,3-dimethyl-1-oxobutyl]amino]-4-phenylbutyl]-2-[[4-(2-pyridinyl)phenyl]methyl]hydrazide, (2S)-, sulfate (1:1) (salt)
• BMS-232632-05
• Atazanavir Bisulfate Salt
• Atazanavir sulfate
• [(1S,4S,5S,10S)-4-benzyl-1,10-bis(1,1-diméthyléthyl)-5-hydroxy-2,9,12-trioxo-7-(4-pyridin-2-ylbenzyl)-13-oxa-3,7,8,11-tétraazatétradéc-1-yl]carbamate de méthyle sulfate (salt)
• Reyataz {Sulfate}
• butanoic acid, 2-[(methoxycarbonyl)amino]-3,3-dimethyl-, 2-[(2S,3S)-2-hydroxy-3-[[(2S)-2-[(methoxycarbonyl)amino]-3,3-dimethyl-1-oxobutyl]amino]-4-phenylbutyl]-2-[[4-(2-pyridinyl)phenyl]methyl]hydrazi
• de, (2S)-, sulfate (1:1) (salt)
• Methyl-[(1S,4S,5S,10S)-4-benzyl-1,10-di-tert-butyl-5-hydroxy-2,9,12-trioxo-7-(4-pyridin-2-ylbenzyl)-13-oxa-3,7,8,11-tetraazatetradec-1-yl]carbamatsulfat(salt)
• Atazanavir (sulfate)