Physalin B

• 常用名: Physalin B
• 英文名: Physalin B
• CAS号: 23133-56-4
• 分子量: 510.53200
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₈H₃₀O₉
• 熔点: N/A
• 闪点: N/A

Physalin B用途

Physalin B 是 Cape gooseberry 中主要的甾体活性成分之一,通过调节 p53 依赖的凋亡途径,诱导乳腺癌细胞周期阻滞和诱导凋亡 (apoptosis)。Physalin B 抑制人结肠癌细胞泛素-蛋白酶体通路并诱导不完全自噬反应。

Physalin B名称

• 中文名: 酸浆苦味B
• 英文名: physalin B

Physalin B生物活性

• 描述: Physalin B 是 Cape gooseberry 中主要的甾体活性成分之一,通过调节 p53 依赖的凋亡途径,诱导乳腺癌细胞周期阻滞和诱导凋亡 (apoptosis)。Physalin B 抑制人结肠癌细胞泛素-蛋白酶体通路并诱导不完全自噬反应。
• 相关类别:
  信号通路 >> 细胞凋亡 >> 细胞凋亡
  研究领域 >> 癌症
  信号通路 >> 自噬 >> 自噬
• 参考文献:

  [1]. Wang A, et al. Physalin B induces cell cycle arrest and triggers apoptosis in breast cancer cells through modulating p53-dependent apoptotic pathway. Biomed Pharmacother. 2018;101:334-341.

  [2]. Ma YM, et al. Physalin B not only inhibits the ubiquitin-proteasome pathway but also induces incomplete autophagic response in human colon cancer cells in vitro. Acta Pharmacol Sin. 2015;36(4):517-527.

Physalin B物理化学性质

• 分子式: C₂₈H₃₀O₉
• 分子量: 510.53200
• 精确质量: 510.18900
• PSA: 125.43000
• LogP: 1.55700
• InChIKey: HVTFEHJSUSPQBK-DNJDGUCCSA-N
• SMILES: CC12C(=O)C=CCC1=CCC1C2CCC2(O)C(=O)OC3(C)C4CC5(C)C(COC16OC23C5C6=O)C(=O)O4
• 储存条件: 2-8°C，干燥，密封

Physalin B安全信息

• 危害码 (欧洲): Xi

Physalin B靶点实验

查看更多实验

实验名称：Inhibition of peptide-glutamyl-peptide-hydrolyzing activity of 20S proteasome in huma... 来源：ChEMBL 靶标：N/A External Id：CHEMBL1942848

实验名称：Inhibition of chymotrypsin-like activity of 20S proteasome in human DLD1 cells transf... 来源：ChEMBL 靶标：N/A External Id：CHEMBL1942849

实验名称：Cytotoxicity against human NCI-H460 cells assessed as cell growth inhibition measured... 来源：ChEMBL 靶标：NCI-H460 External Id：CHEMBL4815641

实验名称：Cytotoxicity against human SF-268 cells assessed as cell growth inhibition measured a... 来源：ChEMBL 靶标：SF-268 External Id：CHEMBL4815642

实验名称：Cytotoxicity against human PC-3 cells assessed as cell growth inhibition measured aft... 来源：ChEMBL 靶标：PC-3 External Id：CHEMBL4815639

实验名称：Cytotoxicity against human MCF7 cells assessed as cell growth inhibition measured aft... 来源：ChEMBL 靶标：MCF7 External Id：CHEMBL4815640

实验名称：Cytotoxicity against human WI-38 cells assessed as cell growth inhibition measured af... 来源：ChEMBL 靶标：WI-38 External Id：CHEMBL4815643

实验名称：Inhibition of GLI1 (unknown origin) transcriptional activity 来源：ChEMBL 靶标：Zinc finger protein GLI1 External Id：CHEMBL5250706

实验名称：Antitumor activity against human LNCAP cells 来源：ChEMBL 靶标：LNCaP External Id：CHEMBL889079

实验名称：Antitumor activity against human KB cells 来源：ChEMBL 靶标：KB External Id：CHEMBL889080

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