四氢胡椒碱

• 常用名: 四氢胡椒碱
• 英文名: Tetrahydropiperin
• CAS号: 23434-88-0
• 分子量: 289.369
• 密度: 1.2±0.1 g/cm3
• 沸点: 469.9±24.0 °C at 760 mmHg
• 分子式: C₁₇H₂₃NO₃
• 熔点: 41ºC
• 闪点: 238.0±22.9 °C

四氢胡椒碱用途

Tetrahydropiperine 是胡椒碱的环己基类似物,是来自 Piper longum 的第一种天然芳基戊酰胺。 Tetrahydropiperine (compound 14) 抑制细胞色素 P450 (CYP) 同工型 CYP1A1/芳基烃羟化酶 (AHH；IC50=23 µM)。

四氢胡椒碱名称

• 中文名: 四氢胡椒碱
• 英文名: 5-(1,3-benzodioxol-5-yl)-1-piperidin-1-ylpentan-1-one

四氢胡椒碱生物活性

• 描述: Tetrahydropiperine 是胡椒碱的环己基类似物,是来自 Piper longum 的第一种天然芳基戊酰胺。 Tetrahydropiperine (compound 14) 抑制细胞色素 P450 (CYP) 同工型 CYP1A1/芳基烃羟化酶 (AHH；IC50=23 µM)。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 代谢酶/蛋白酶 >> 细胞色素P450
• 靶点实验:

  CYP1A1:23 μM (IC50)

• 参考文献:

  [1]. Madhusudhan P, et al. Tetrahydropiperine, the first natural aryl pentanamide from Piper longum. Biochem Syst Ecol. 2001 May;29(5):537-538.

  [2]. Koul S, et al. Structure-activity relationship of piperine and its synthetic analogues for their inhibitory potentials of rat hepatic microsomal constitutive and inducible cytochromeP450 activities. Bioorg Med Chem. 2000 Jan;8(1):251-68.

四氢胡椒碱物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 469.9±24.0 °C at 760 mmHg
• 熔点: 41ºC
• 分子式: C₁₇H₂₃NO₃
• 分子量: 289.369
• 闪点: 238.0±22.9 °C
• 精确质量: 289.167786
• PSA: 38.77000
• LogP: 3.67
• InChIKey: APZYKUZPJCQGPP-UHFFFAOYSA-N
• SMILES: O=C(CCCCc1ccc2c(c1)OCO2)N1CCCCC1
• 外观性状: 灰白色低熔点固体带有特有的气味
• 蒸汽压: 0.0±1.2 mmHg at 25°C
• 折射率: 1.556
• 储存条件: -20℃

四氢胡椒碱靶点实验

查看更多实验

实验名称：Inhibition of NorA efflux pump in Staphylococcus aureus 1199B assessed as reduction o... 来源：ChEMBL 靶标：Quinolone resistance protein NorA External Id：CHEMBL1040409

实验名称：Inhibition of NorA efflux pump in Staphylococcus aureus 1199B assessed as potentiatio... 来源：ChEMBL 靶标：Quinolone resistance protein NorA External Id：CHEMBL1040410

实验名称：Positive allosteric modulation of GluN1/N2B (unknown origin) transfected in HEK293 ce... 来源：ChEMBL 靶标：Glutamate receptor ionotropic, NMDA 2B External Id：CHEMBL5389935

实验名称：Inhibition of NorA efflux pump in Staphylococcus aureus 1199B assessed as accumulatio... 来源：ChEMBL 靶标：Quinolone resistance protein NorA External Id：CHEMBL1040408

实验名称：In vitro growth inhibition of epimastigotes of Trypanosoma cruzi 来源：ChEMBL 靶标：Trypanosoma cruzi External Id：CHEMBL812102

实验名称：Antitrypanosomal activity against epimastigote forms of Trypanosoma cruzi Y after 72 ... 来源：ChEMBL 靶标：Trypanosoma cruzi External Id：CHEMBL3059482

实验名称：Agonist activity at human TRPV1 expressed in tetracycline-stimulated HEK293 cells ass... 来源：ChEMBL 靶标：Transient receptor potential cation channel subfamily V member 1 External Id：CHEMBL1121358

实验名称：Agonist activity at human TRPV1 expressed in HEK293 cells assessed as increase in int... 来源：ChEMBL 靶标：Transient receptor potential cation channel subfamily V member 1 External Id：CHEMBL1121357

实验名称：Antimicrobial activity against Trypanosoma cruzi 来源：ChEMBL 靶标：Trypanosoma cruzi External Id：CHEMBL1216998

实验名称：Inhibition of NorA efflux pump in Staphylococcus aureus 1199B assessed as fold reduct... 来源：ChEMBL 靶标：Quinolone resistance protein NorA External Id：CHEMBL989857

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四氢胡椒碱英文别名

• 1-[5-(1,3-Benzodioxol-5-yl)pentanoyl]piperidine
• Tetrahydropiperidine
• 5-(1,3-Benzodioxol-5-yl)-1-(piperidin-1-yl)pentan-1-one
• Tetrahydropiperin
• 5-(1,3-Benzodioxol-5-yl)-1-(1-piperidinyl)-1-pentanone
• Cosmoperine
• Tetrahydropiperine