15-LOX-1 inhibitor 1

• 常用名: 15-LOX-1 inhibitor 1
• 英文名: 15-LOX-1 inhibitor 1
• CAS号: 2349374-37-2
• 分子量: 412.866
• 密度: 1.3±0.1 g/cm3
• 沸点: 683.5±55.0 °C at 760 mmHg
• 分子式: C₂₂H₂₁ClN₂O₄
• 熔点: N/A
• 闪点: 367.2±31.5 °C

15-LOX-1 inhibitor 1用途

15-LOX-1抑制剂1是15-LOX-1(15-脂氧合酶-1)的有效抑制剂,IC50值为0.19μM。15-LOX-1抑制剂1保护巨噬细胞免受脂多糖诱导的细胞毒性。15-LOX-1抑制剂1抑制NO生成和脂质过氧化[1]。

15-LOX-1 inhibitor 1名称

• 英文名: 9c(i472)

15-LOX-1 inhibitor 1生物活性

• 描述: 15-LOX-1抑制剂1是15-LOX-1(15-脂氧合酶-1)的有效抑制剂,IC50值为0.19μM。15-LOX-1抑制剂1保护巨噬细胞免受脂多糖诱导的细胞毒性。15-LOX-1抑制剂1抑制NO生成和脂质过氧化[1]。
• 相关类别:
  研究领域 >> 炎症/免疫
  信号通路 >> 代谢酶/蛋白酶 >> 5脂氧合酶
• 靶点实验:

  15-LOX-1:0.19 μM (IC50)

• 体外研究: 15-LOX-1抑制剂1(化合物9c)(0-5 μM；24小时)保护RAW 264.7巨噬细胞免受LPS诱导的细胞死亡,并显示出更强的剂量依赖性效应,在5μM浓度下存活率增加20%[1]。细胞活力测定[1]细胞系：原始264.7巨噬细胞浓度：0,0.2,1,5 μM 15-LOX-1抑制剂1和脂多糖(100μg/mL)孵育时间：24小时结果：在5μM时表现出更强的剂量依赖性效应,活力增加20%。
• 参考文献:

  [1]. Guo H, et al. Novel 15-Lipoxygenase-1 Inhibitor Protects Macrophages from Lipopolysaccharide-Induced Cytotoxicity. J Med Chem. 2019;62(9):4624-4637.

15-LOX-1 inhibitor 1物理化学性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 683.5±55.0 °C at 760 mmHg
• 分子式: C₂₂H₂₁ClN₂O₄
• 分子量: 412.866
• 闪点: 367.2±31.5 °C
• 精确质量: 412.118988
• LogP: 4.74
• 蒸汽压: 0.0±2.1 mmHg at 25°C
• 折射率: 1.648

15-LOX-1 inhibitor 1靶点实验

查看更多实验

实验名称：Inhibition of 15LOX1 in LPS/IFNgamma-stimulated mouse RAW264.7 cells assessed as down... 来源：ChEMBL 靶标：Polyunsaturated fatty acid lipoxygenase ALOX15 External Id：CHEMBL4386473

实验名称：Inhibition of 15LOX1 in mouse RAW blue cells assessed as suppression of LPS/IFNgamma-... 来源：ChEMBL 靶标：Polyunsaturated fatty acid lipoxygenase ALOX15 External Id：CHEMBL4386474

实验名称：Inhibition of LPS/IFNgamma-stimulated lipid peroxidation in mouse RAW264.7 cells at 5... 来源：ChEMBL 靶标：RAW264.7 External Id：CHEMBL4386475

实验名称：Protection against LPS-induced cell death in mouse RAW264.7 cells assessed as increas... 来源：ChEMBL 靶标：RAW264.7 External Id：CHEMBL4386476

实验名称：Inhibition of N144 probe binding to 15-LOX in mouse RAW264.7 cells measured after 2 m... 来源：ChEMBL 靶标：Polyunsaturated fatty acid lipoxygenase ALOX15 External Id：CHEMBL4386477

实验名称：Inhibition of human recombinant N-terminal His6-tagged 15-LOX1 expressed in Escherich... 来源：ChEMBL 靶标：Polyunsaturated fatty acid lipoxygenase ALOX15 External Id：CHEMBL4386469

实验名称：Stability in pH 7.4 2-betamercaptoethanol at 25 to 50 uM by UV-spectra analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL4386470

实验名称：Protection against LPS-induced cell death in mouse RAW264.7 cells assessed as increas... 来源：ChEMBL 靶标：RAW264.7 External Id：CHEMBL4386471

实验名称：Inhibition of 15-LOX1 in LPS/IFNgamma-stimulated mouse RAW264.7 cells assessed as red... 来源：ChEMBL 靶标：Polyunsaturated fatty acid lipoxygenase ALOX15 External Id：CHEMBL4386472

共9条，当前第1页，共1页

1

15-LOX-1 inhibitor 1英文别名

• Ethyl 6-chloro-3-{(1E)-3-[(2-methoxybenzyl)amino]-3-oxo-1-propen-1-yl}-1H-indole-2-carboxylate
• 9c(i472)
• 1H-Indole-2-carboxylic acid, 6-chloro-3-[(1E)-3-[[(2-methoxyphenyl)methyl]amino]-3-oxo-1-propen-1-yl]-, ethyl ester