15-LOX-1 inhibitor 1

Modify Date: 2024-01-09 19:26:17

15-LOX-1 inhibitor 1 structure	Common Name	15-LOX-1 inhibitor 1
	CAS Number	2349374-37-2	Molecular Weight	412.866
	Density	1.3±0.1 g/cm3	Boiling Point	683.5±55.0 °C at 760 mmHg
	Molecular Formula	C₂₂H₂₁ClN₂O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	367.2±31.5 °C

Use of 15-LOX-1 inhibitor 1

15-LOX-1 inhibitor 1 is a potent inhibitor of 15-LOX-1 (15-lipoxygenase-1) with an IC50 value of 0.19 μM. 15-LOX-1 inhibitor 1 protects macrophages from lipopolysaccharide-induced cytotoxicity. 15-LOX-1 inhibitor 1 inhibits NO formation and lipid peroxidation[1].

Name	9c(i472)
Synonym	More Synonyms

Description	15-LOX-1 inhibitor 1 is a potent inhibitor of 15-LOX-1 (15-lipoxygenase-1) with an IC50 value of 0.19 μM. 15-LOX-1 inhibitor 1 protects macrophages from lipopolysaccharide-induced cytotoxicity. 15-LOX-1 inhibitor 1 inhibits NO formation and lipid peroxidation[1].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Metabolic Enzyme/Protease >> 5-Lipoxygenase
Target	15-LOX-1:0.19 μM (IC50)
In Vitro	15-LOX-1 inhibitor 1 (Compound 9c) (0-5 μM; 24 hours) protects RAW 264.7 macrophages from LPS-induced cell death and shows stronger, dose-dependent effects with a 20% viability increase at 5 μM[1]. Cell Viability Assay[1] Cell Line: RAW 264.7 macrophages Concentration: 0, 0.2, 1, 5 μM 15-LOX-1 inhibitor 1 and lipopolysaccharides (LPS) (100 μg/mL) Incubation Time: 24 hours Result: Showed stronger, dose-dependent effects with a 20% viability increase at 5 μM.
References	[1]. Guo H, et al. Novel 15-Lipoxygenase-1 Inhibitor Protects Macrophages from Lipopolysaccharide-Induced Cytotoxicity. J Med Chem. 2019;62(9):4624-4637.

Density	1.3±0.1 g/cm3
Boiling Point	683.5±55.0 °C at 760 mmHg
Molecular Formula	C₂₂H₂₁ClN₂O₄
Molecular Weight	412.866
Flash Point	367.2±31.5 °C
Exact Mass	412.118988
LogP	4.74
Vapour Pressure	0.0±2.1 mmHg at 25°C
Index of Refraction	1.648

Ethyl 6-chloro-3-{(1E)-3-[(2-methoxybenzyl)amino]-3-oxo-1-propen-1-yl}-1H-indole-2-carboxylate

9c(i472)

1H-Indole-2-carboxylic acid, 6-chloro-3-[(1E)-3-[[(2-methoxyphenyl)methyl]amino]-3-oxo-1-propen-1-yl]-, ethyl ester

DC Chemicals Limited
China
Product Name: 15-LOX-1 inhibitor 1
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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