PROTAC VEGFR-2 degrader-2

• 常用名: PROTAC VEGFR-2 degrader-2
• 英文名: PROTAC VEGFR-2 degrader-2
• CAS号: 2353417-85-1
• 分子量: 930.10
• 密度: N/A
• 沸点: N/A
• 分子式: C₅₀H₅₆FN₉O₆S
• 熔点: N/A
• 闪点: N/A

PROTAC VEGFR-2 degrader-2用途

PROTAC VEGFR-2降解剂-2(PROTAC-4)是一种PROTAC VEGFR-2降解物,对血管内皮生长因子受体-2的抑制作用很小(IC50>1μM),对EA具有抗增殖活性。hy926细胞(IC50>100μM)[1]。

PROTAC VEGFR-2 degrader-2名称

• 英文名: PROTAC VEGFR-2 degrader-2

PROTAC VEGFR-2 degrader-2生物活性

• 描述: PROTAC VEGFR-2降解剂-2(PROTAC-4)是一种PROTAC VEGFR-2降解物,对血管内皮生长因子受体-2的抑制作用很小(IC50>1μM),对EA具有抗增殖活性。hy926细胞(IC50>100μM)[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 蛋白裂解靶向嵌合体 >> PROTAC
  信号通路 >> 蛋白酪氨酸激酶 >> VEGFR
• 参考文献:

  [1]. Yuanyuan Shan, et al. Discovery of novel anti-angiogenesis agents. Part 11: Development of PROTACs based on active molecules with potency of promoting vascular normalization. Eur J Med Chem. 2020 Nov 1;205:112654.

PROTAC VEGFR-2 degrader-2物理化学性质

• 分子式: C₅₀H₅₆FN₉O₆S
• 分子量: 930.10

PROTAC VEGFR-2 degrader-2靶点实验

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实验名称：Inhibition of recombinant human N-terminal GST-tagged VEGFR2 (789 to end residues) ex... 来源：ChEMBL 靶标：Vascular endothelial growth factor receptor 2 External Id：CHEMBL4773366

实验名称：Antiangiogenic activity in human EA.hy 926 cells measured after 24 hrs by MTT assay 来源：ChEMBL 靶标：EA.hy 926 External Id：CHEMBL4773367

实验名称：Cytotoxicity against HEK293 cells measured after 24 hrs by MTT assay 来源：ChEMBL 靶标：HEK293 External Id：CHEMBL4773368

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