ENPP1 Inhibitor C

• 常用名: ENPP1 Inhibitor C
• 英文名: ENPP1 Inhibitor C
• CAS号: 2378640-92-5
• 分子量: 282.344
• 密度: 1.3±0.1 g/cm3
• 沸点: N/A
• 分子式: C₁₅H₁₈N₆
• 熔点: N/A
• 闪点: N/A

ENPP1 Inhibitor C用途

Enpp-1-IN-2(化合物C)是一种有效的ENPP1(外核苷酸焦磷酸酶/磷酸二酯酶1)抑制剂,其IC50值分别为0.26、0.48和2.0μM,通过TG-mAMP、pNP-TMP和ATP分析进行评估。TG(东京绿)-mAMP：一种新合成的灵敏ENPP1荧光探针[1]。

ENPP1 Inhibitor C名称

• 英文名: ENPP1 Inhibitor C

ENPP1 Inhibitor C生物活性

• 描述: Enpp-1-IN-2(化合物C)是一种有效的ENPP1(外核苷酸焦磷酸酶/磷酸二酯酶1)抑制剂,其IC50值分别为0.26、0.48和2.0μM,通过TG-mAMP、pNP-TMP和ATP分析进行评估。TG(东京绿)-mAMP：一种新合成的灵敏ENPP1荧光探针[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 代谢酶/蛋白酶 >> 磷酸二酯酶(PDE)
• 靶点实验:

  IC50: 0.26 μM (TG-mAMP assay), 0.48 μM (pNP-TMP assay), 2.0 μM (ATP assay)[1]

• 参考文献:

  [1]. Kawaguchi M, et al. Development of an ENPP1 Fluorescence Probe for Inhibitor Screening, Cellular Imaging, and Prognostic Assessment of Malignant Breast Cancer. J Med Chem. 2019 Oct 24;62(20):9254-9269.

ENPP1 Inhibitor C物理化学性质

• 密度: 1.3±0.1 g/cm3
• 分子式: C₁₅H₁₈N₆
• 分子量: 282.344
• 精确质量: 282.159302
• LogP: 1.10
• InChIKey: VUDSCOCEYOZLJD-UHFFFAOYSA-N
• SMILES: Cc1nc2ncnn2c(N(C)C)c1Cc1cccc(N)c1
• 折射率: 1.679

ENPP1 Inhibitor C靶点实验

查看更多实验

实验名称：Inhibition of ENPP3 (unknown origin) assessed as reduction in 2'3'-cGAMP hydrolysis a... 来源：ChEMBL 靶标：Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 External Id：CHEMBL5577076

实验名称：Cytotoxicity against human THP1-Dual cells upto 50 uM 来源：ChEMBL 靶标：THP1-Dual External Id：CHEMBL5577077

实验名称：Cytotoxicity against human HepG2-Dual cells upto 50 uM 来源：ChEMBL 靶标：N/A External Id：CHEMBL5577078

实验名称：Inhibition of ENPP1 in human HepG2-dual cells assessed as reduction in fluorescence s... 来源：ChEMBL 靶标：Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 External Id：CHEMBL5577079

实验名称：Inhibition of ENPP1 (unknown origin) at 30 uM relative to control 来源：ChEMBL 靶标：Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 External Id：CHEMBL5577065

实验名称：Inhibition of ENPP3 (unknown origin) at 50 uM relative to control 来源：ChEMBL 靶标：Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 External Id：CHEMBL5577066

实验名称：Inhibition of ENPP2 (unknown origin) at 50 uM relative to control 来源：ChEMBL 靶标：Autotaxin External Id：CHEMBL5577067

实验名称：Inhibition of ENPP6 (unknown origin) at 50 uM relative to control 来源：ChEMBL 靶标：Glycerophosphocholine cholinephosphodiesterase ENPP6 External Id：CHEMBL5577068

实验名称：Inhibition of ENPP1 (unknown origin) assessed as reduction in ATP hydrolysis at 50 uM... 来源：ChEMBL 靶标：Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 External Id：CHEMBL5577073

实验名称：Inhibition of ENPP1 (unknown origin) assessed as reduction in 2'3'-cGAMP hydrolysis a... 来源：ChEMBL 靶标：Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 External Id：CHEMBL5577074

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ENPP1 Inhibitor C英文别名

• ENPP1 Inhibitor C
• 6-(3-Aminobenzyl)-N,N,5-trimethyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine