hCAIX-IN-8

• 常用名: hCAIX-IN-8
• 英文名: hCAIX-IN-8
• CAS号: 2414633-40-0
• 分子量: 396.35
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₉H₁₆N₄O₆
• 熔点: N/A
• 闪点: N/A

hCAIX-IN-8用途

hCAIX-IN-8(化合物7i)是一种高效、选择性的hCAIX抑制剂,对CAII、CAIX、CAVA的IC50s分别为1.99、0.024、1.10µM。hCAIX-IN-8具有低毒性的抗增殖活性。hCAIX-IN-8可减少上皮细胞向间充质细胞的转化并诱导细胞凋亡。hCAIX-IN-8抑制细胞迁移和定植潜能[1]。

hCAIX-IN-8名称

• 英文名: hCAIX-IN-8

hCAIX-IN-8生物活性

• 描述: hCAIX-IN-8(化合物7i)是一种高效、选择性的hCAIX抑制剂,对CAII、CAIX、CAVA的IC50s分别为1.99、0.024、1.10µM。hCAIX-IN-8具有低毒性的抗增殖活性。hCAIX-IN-8可减少上皮细胞向间充质细胞的转化并诱导细胞凋亡。hCAIX-IN-8抑制细胞迁移和定植潜能[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 代谢酶/蛋白酶 >> 碳酸酐酶
• 靶点实验:

  IC50: 1.99 µM (CAII); 0.024 (CAIX), 1.10 µM (CAVA)[1]

• 体外研究: hCAIX-IN-8(化合物7i)具有IC50的抗增殖活性是HT29、HepG2细胞分别为8.44、11.22µM[1]。hCAIX-IN-8分别诱导24.44%和19.22%的HT29和HepG2细胞凋亡,以上结果均大于[1]。
• 参考文献:

  [1]. Aneja B,et al. Design, synthesis & biological evaluation of ferulic acid-based small molecule inhibitors against tumor-associated carbonic anhydrase IX. Bioorg Med Chem. 2020 May 1;28(9):115424.

hCAIX-IN-8物理化学性质

• 分子式: C₁₉H₁₆N₄O₆
• 分子量: 396.35

hCAIX-IN-8靶点实验

查看更多实验

实验名称：Inhibition of human carbonic anhydrase 9 using p-nitrophenyl acetate as substrate by ... 来源：ChEMBL 靶标：Carbonic anhydrase 9 External Id：CHEMBL4620215

实验名称：Inhibition of human carbonic anhydrase 2 using p-nitrophenyl acetate as substrate by ... 来源：ChEMBL 靶标：Carbonic anhydrase 2 External Id：CHEMBL4620214

实验名称：Selectivity index, ratio of IC50 for human carbonic anhydrase 2 using p-nitrophenyl a... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4620217

实验名称：Inhibition of human carbonic anhydrase 5A using p-nitrophenyl acetate as substrate by... 来源：ChEMBL 靶标：Carbonic anhydrase 5A, mitochondrial External Id：CHEMBL4620216

实验名称：Binding affinity to human carbonic anhydrase 9 assessed as decrease in emission inten... 来源：ChEMBL 靶标：Carbonic anhydrase 9 External Id：CHEMBL4620219

实验名称：Selectivity index, ratio of IC50 for human carbonic anhydrase 2 using p-nitrophenyl a... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4620218

实验名称：Binding affinity to human carbonic anhydrase 9 assessed as change in enthalpy by isot... 来源：ChEMBL 靶标：Carbonic anhydrase 9 External Id：CHEMBL4620220

实验名称：Down regulation of carbonic anhydrase 9 mRNA expression in human HepG2 cells by RT-PC... 来源：ChEMBL 靶标：HepG2 External Id：CHEMBL4620255

实验名称：Down regulation of carbonic anhydrase 9 mRNA expression in human HT-29 cells by RT-PC... 来源：ChEMBL 靶标：HT-29 External Id：CHEMBL4620254

实验名称：Induction of apoptosis in human HepG2 cells assessed as early apoptotic cells at IC50... 来源：ChEMBL 靶标：HepG2 External Id：CHEMBL4620247

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