FC-116

• 常用名: FC-116
• 英文名: FC-116
• CAS号: 2417298-29-2
• 分子量: 369.39
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₁H₂₀FNO₄
• 熔点: N/A
• 闪点: N/A

FC-116用途

FC-11是一种微管蛋白抑制剂,可有效抑制小鼠肿瘤生长。FC-11还可以诱导内质网(ER)应激产生过量的活性氧(ROS),导致线粒体损伤,从而通过靶向微管促进癌症(CRC)细胞凋亡。FC-11可用于癌症研究[1]。

FC-116名称

• 英文名: FC-116

FC-116生物活性

• 描述: FC-11是一种微管蛋白抑制剂,可有效抑制小鼠肿瘤生长。FC-11还可以诱导内质网(ER)应激产生过量的活性氧(ROS),导致线粒体损伤,从而通过靶向微管促进癌症(CRC)细胞凋亡。FC-11可用于癌症研究[1]。
• 相关类别:
  信号通路 >> 细胞凋亡 >> 细胞凋亡
  研究领域 >> 癌症
  信号通路 >> 细胞周期/DNA损伤 >> 微管/微管蛋白
  信号通路 >> 细胞骨架 >> 微管/微管蛋白
• 参考文献:

  [1]. Liu X, et al. Fluoroindole chalcone analogues targeting the colchicine binding site of tubulin for colorectal oncotherapy. Eur J Med Chem. 2023 Sep 5;257:115540.

FC-116物理化学性质

• 分子式: C₂₁H₂₀FNO₄
• 分子量: 369.39

FC-116靶点实验

查看更多实验

实验名称：Cytotoxicity against human HCT-116 cells assessed as growth inhibition measured after... 来源：ChEMBL 靶标：HCT-116 External Id：CHEMBL5621982

实验名称：Antiproliferative activity against human NCM460 cells assessed as inhibition of proli... 来源：ChEMBL 靶标：NCM460 External Id：CHEMBL5621985

实验名称：Antiproliferative activity against rat PC12 cells assessed as inhibition of prolifera... 来源：ChEMBL 靶标：PC-12 External Id：CHEMBL5621986

实验名称：Antiproliferative activity against human HCT-116 cells assessed as dead cells at 2.5 ... 来源：ChEMBL 靶标：HCT-116 External Id：CHEMBL5621987

实验名称：Antiproliferative activity against mouse CT26 cells assessed as dead cells at 2.5 to ... 来源：ChEMBL 靶标：CT26 External Id：CHEMBL5621988

实验名称：Induction of apoptosis in human HCT116 cells assessed as dead cells cells at 2.5 to 2... 来源：ChEMBL 靶标：HCT-116 External Id：CHEMBL5621989

实验名称：Induction of mitochondrial damage in mouse CT26 cells at 10 to 40 nM measured after 2... 来源：ChEMBL 靶标：CT26 External Id：CHEMBL5622022

实验名称：Induction of endoplasmic reticulum (ER) stress in human HCT-116 cells assessed as inc... 来源：ChEMBL 靶标：HCT-116 External Id：CHEMBL5622023

实验名称：Induction of endoplasmic reticulum (ER) stress in mouse CT26 cells assessed as increa... 来源：ChEMBL 靶标：CT26 External Id：CHEMBL5622024

实验名称：Induction of endoplasmic reticulum (ER) stress in human HCT-116 cells assessed as inc... 来源：ChEMBL 靶标：HCT-116 External Id：CHEMBL5622025

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