CYP3A4-IN-2

• 常用名: CYP3A4-IN-2
• 英文名: CYP3A4-IN-2
• CAS号: 2562383-94-0
• 分子量: 570.74
• 密度: N/A
• 沸点: N/A
• 分子式: C₃₃H₃₈N₄O₃S
• 熔点: N/A
• 闪点: N/A

CYP3A4-IN-2用途

CYP3A4-IN-2是细胞色素P450 3A4(CYP3A4)的特异性抑制剂,其IC50值为0.055μM。CYP3A4-IN-2是一种利托那韦类似物,R2侧基团的疏水性增加,与利托那维尔相比具有更强的抑制作用。CYP3A4-IN-2可用作抗病毒药物和免疫抑制剂[1]。

CYP3A4-IN-2名称

• 英文名: CYP3A4-IN-2

CYP3A4-IN-2生物活性

• 描述: CYP3A4-IN-2是细胞色素P450 3A4(CYP3A4)的特异性抑制剂,其IC50值为0.055μM。CYP3A4-IN-2是一种利托那韦类似物,R2侧基团的疏水性增加,与利托那维尔相比具有更强的抑制作用。CYP3A4-IN-2可用作抗病毒药物和免疫抑制剂[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 代谢酶/蛋白酶 >> 细胞色素P450
  研究领域 >> 炎症/免疫
• 靶点实验:

  CYP3A4:0.055 μM (IC50)

• 参考文献:

  [1]. Eric R Samuels, et al. An increase in side-group hydrophobicity largely improves the potency of ritonavir-like inhibitors of CYP3A4. Bioorg Med Chem. 2020 Mar 15;28(6):115349. doi: 10.1016/j.bmc.2020.115349. Epub 2020 Jan 31.

CYP3A4-IN-2物理化学性质

• 分子式: C₃₃H₃₈N₄O₃S
• 分子量: 570.74

CYP3A4-IN-2靶点实验

查看更多实验

实验名称：Binding affinity to human full length CYP3A4 assessed as change in melting temperatur... 来源：ChEMBL 靶标：Cytochrome P450 3A4 External Id：CHEMBL4617574

实验名称：Binding affinity to human full length CYP3A4 assessed as rate constants for the fast ... 来源：ChEMBL 靶标：Cytochrome P450 3A4 External Id：CHEMBL4617577

实验名称：Binding affinity to human full length CYP3A4 assessed as change in maximum absorbance... 来源：ChEMBL 靶标：Cytochrome P450 3A4 External Id：CHEMBL4617576

实验名称：Binding affinity to human full length CYP3A4 assessed as rate constants for the fast ... 来源：ChEMBL 靶标：Cytochrome P450 3A4 External Id：CHEMBL4617579

实验名称：Binding affinity to human full length CYP3A4 assessed as rate constants for the fast ... 来源：ChEMBL 靶标：Cytochrome P450 3A4 External Id：CHEMBL4617578

实验名称：Binding affinity to human full length CYP3A4 assessed as maximum absorption wavelengt... 来源：ChEMBL 靶标：Cytochrome P450 3A4 External Id：CHEMBL4617581

实验名称：Binding affinity to human full length CYP3A4 assessed as rate constants for the fast ... 来源：ChEMBL 靶标：Cytochrome P450 3A4 External Id：CHEMBL4617580

实验名称：Binding affinity to human full length CYP3A4 assessed as spectral dissociation consta... 来源：ChEMBL 靶标：Cytochrome P450 3A4 External Id：CHEMBL4617571

实验名称：Ratio of IC50 for inhibition of human full length CYP3A4 to binding affinity to human... 来源：ChEMBL 靶标：Cytochrome P450 3A4 External Id：CHEMBL4617573

实验名称：Inhibition of human full length CYP3A4 assessed using 7-benzyloxy-4 (trifluoromethyl)... 来源：ChEMBL 靶标：Cytochrome P450 3A4 External Id：CHEMBL4617572

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