15-keto Prostaglandin E2

• 常用名: 15-keto Prostaglandin E2
• 英文名: 15-keto Prostaglandin E2
• CAS号: 26441-05-4
• 分子量: 350.45
• 密度: 1.1±0.1 g/cm3
• 沸点: 534.4±50.0 °C at 760 mmHg
• 分子式: C₂₀H₃₀O₅
• 熔点: N/A
• 闪点: 291.1±26.6 °C

15-keto Prostaglandin E2用途

15-keto-Prostaglandin E2 是一种内源性代谢物。15-keto-Prostaglandin E2 通过 STAT3 Cys259 残基结合来抑制 STAT3 激活。15-keto-Prostaglandin E2 可以结合并稳定 EP2 和 EP4 受体。15-keto-Prostaglandin E2 抑制乳腺癌细胞的生长和进展。15-keto-Prostaglandin E2 激活 PPAR-γ 并促进真菌生长。

15-keto Prostaglandin E2名称

• 英文名: 15-dehydro-prostaglandin E2

15-keto Prostaglandin E2生物活性

• 描述: 15-keto-Prostaglandin E2 是一种内源性代谢物。15-keto-Prostaglandin E2 通过 STAT3 Cys259 残基结合来抑制 STAT3 激活。15-keto-Prostaglandin E2 可以结合并稳定 EP2 和 EP4 受体。15-keto-Prostaglandin E2 抑制乳腺癌细胞的生长和进展。15-keto-Prostaglandin E2 激活 PPAR-γ 并促进真菌生长。
• 相关类别:
  信号通路 >> 干细胞及 Wnt 通路 >> STAT
  研究领域 >> 癌症
  信号通路 >> JAK/STAT信号通路 >> STAT
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 前列腺素受体
  信号通路 >> 细胞周期/DNA损伤 >> PPAR
• 参考文献:

  [1]. Lee EJ, et al. 15-Keto prostaglandin E2 suppresses STAT3 signaling and inhibits breast cancer cell growth and progression. Redox Biol. 2019 May;23:101175.

  [2]. Kourpa A, et al. 15-keto-Prostaglandin E2 exhibits bioactive role by modulating glomerular cytoarchitecture through EP2/EP4 receptors. Life Sci. 2022 Dec 1;310:121114.

  [3]. Evans RJ, et al. 15-keto-prostaglandin E2 activates host peroxisome proliferator-activated receptor gamma (PPAR-γ) to promote Cryptococcus neoformans growth during infection. PLoS Pathog. 2019 Mar 28;15(3):e1007597.

15-keto Prostaglandin E2物理化学性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 534.4±50.0 °C at 760 mmHg
• 分子式: C₂₀H₃₀O₅
• 分子量: 350.45
• 闪点: 291.1±26.6 °C
• 精确质量: 350.209320
• PSA: 91.67000
• LogP: 1.74
• InChIKey: YRTJDWROBKPZNV-KMXMBPPJSA-N
• SMILES: CCCCCC(=O)C=CC1C(O)CC(=O)C1CC=CCCCC(=O)O
• 蒸汽压: 0.0±3.2 mmHg at 25°C
• 折射率: 1.552

15-keto Prostaglandin E2靶点实验

查看更多实验

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15-keto Prostaglandin E2英文别名

• 15-KetoPGE2
• 15-keto-prostaglandin E2
• 9,15-DIOXO-11ALPHA-HYDROXY-PROSTA-5Z,13E-DIEN-1-OIC ACID
• 15-Oxoprostaglandin E2
• (5Z,11α,13E)-11-Hydroxy-9,15-dioxoprosta-5,13-dien-1-oic acid
• 15-KETO PROSTAGLANDIN E2
• 15-keto Prostaglandin E2 Lipid Maps MS Standard