VPC-13789

• 常用名: VPC-13789
• 英文名: VPC-13789
• CAS号: 2761146-51-2
• 分子量: 383.37
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₁H₁₆F₃N₃O
• 熔点: N/A
• 闪点: N/A

VPC-13789用途

VPC-13789是一种有效的、选择性的、口服生物利用的抗雄激素药物。VPC-13789可用于抗去势前列腺癌(CRPC)治疗的研究。VPC-13789抑制LNCaP细胞中雄激素受体(AR)的转录活性(IC50=0.19μM)[1]。

VPC-13789名称

• 英文名: VPC-13789

VPC-13789生物活性

• 描述: VPC-13789是一种有效的、选择性的、口服生物利用的抗雄激素药物。VPC-13789可用于抗去势前列腺癌(CRPC)治疗的研究。VPC-13789抑制LNCaP细胞中雄激素受体(AR)的转录活性(IC50=0.19μM)[1]。
• 相关类别:
  研究领域 >> 癌症
  研究领域 >> 内分泌
  信号通路 >> 其他 >> 雄激素受体
• 参考文献:

  [1]. Eric Leblanc , et al. Development of 2-(5,6,7-Trifluoro-1 H-Indol-3-yl)-quinoline-5-carboxamide as a Potent, Selective, and Orally Available Inhibitor of Human Androgen Receptor Targeting Its Binding Function-3 for the Treatment of Castration-Resistant Prostate Cancer. J Med Chem. 2021 Oct 28;64(20):14968-14982.

VPC-13789物理化学性质

• 分子式: C₂₁H₁₆F₃N₃O
• 分子量: 383.37

VPC-13789靶点实验

查看更多实验

实验名称：Tmax in Nude-Foxnl mouse xenografted with human LNCAP cells at 50 mg/kg, po measured ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4828583

实验名称：AUC in Nude-Foxnl mouse xenografted with human LNCAP cells at 50 mg/kg, po measured a... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4828587

实验名称：Half life in po dosed mouse measured after 1 to 24 hrs by HPLC analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL4828576

实验名称：Tmax in mouse measured after 1 to 24 hrs by HPLC analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL4828577

实验名称：Antagonist activity at androgen receptor in DHT-treated human LNCaP cells assessed as... 来源：ChEMBL 靶标：Androgen receptor External Id：CHEMBL4828574

实验名称：Oral bioavailability in mouse measured after 1 to 24 hrs by HPLC analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL4828575

实验名称：Prodrug conversion in mouse small intestine homogenate assessed as formation of paren... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4828580

实验名称：Half life in Nude-Foxnl mouse xenografted with human LNCAP cells at 50 mg/kg, po meas... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4828581

实验名称：Tmax in mouse using sesame oil formulation measured after 1 to 24 hrs by HPLC analysi... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4828579

实验名称：Antagonist activity at androgen receptor (unknown origin) in 293T cells assessed as i... 来源：ChEMBL 靶标：Androgen receptor External Id：CHEMBL4828568

共30条，当前第1页，共3页

1

2

3