PD-1/PD-L1-IN-32

• 常用名: PD-1/PD-L1-IN-32
• 英文名: PD-1/PD-L1-IN-32
• CAS号: 2765535-21-3
• 分子量: 517.98
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₉H₂₅ClFN₃O₃
• 熔点: N/A
• 闪点: N/A

PD-1/PD-L1-IN-32用途

PD-1/PD-L1-IN-32 (compound A56) 是一种有效的 PD-1/PD-L1 抑制剂 (IC50=2.4 nM),具有抗癌活性。PD-1/PD-L1-IN-32 能显著抑制 hPD-L1 MC38 人源化小鼠模型的肿瘤生长,对小鼠无明显毒性。

PD-1/PD-L1-IN-32名称

• 英文名: PD-1/PD-L1-IN-32

PD-1/PD-L1-IN-32生物活性

• 描述: PD-1/PD-L1-IN-32 (compound A56) 是一种有效的 PD-1/PD-L1 抑制剂 (IC50=2.4 nM),具有抗癌活性。PD-1/PD-L1-IN-32 能显著抑制 hPD-L1 MC38 人源化小鼠模型的肿瘤生长,对小鼠无明显毒性。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 免疫及炎症 >> PD-1/PD-L1
• 靶点实验:

  IC50: 2.4 nM (PD-1/PD-L1)[1]

• 参考文献:

  [1]. Zhang H, et al. Design, Synthesis, and Antitumor Activity Evaluation of 2-Arylmethoxy-4-(2,2'-dihalogen-substituted biphenyl-3-ylmethoxy) Benzylamine Derivatives as Potent PD-1/PD-L1 Inhibitors. J Med Chem. 2023 Aug 10;66(15):10579-10603.

PD-1/PD-L1-IN-32物理化学性质

• 分子式: C₂₉H₂₅ClFN₃O₃
• 分子量: 517.98

PD-1/PD-L1-IN-32靶点实验

查看更多实验

实验名称：Tmax in Sprague-Dawley rat at 40 mg/kg, IG measured upto 48 hrs by LC-MS/MS analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL5364030

实验名称：Tmax in Sprague-Dawley rat at 10 mg/kg, ip measured upto 48 hrs by LC-MS/MS analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL5364031

实验名称：Tmax in Sprague-Dawley rat at 8 mg/kg, iv measured upto 48 hrs by LC-MS/MS analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL5364029

实验名称：AUC (0 to infinity) in Sprague-Dawley rat at 40 mg/kg, IG measured upto 48 hrs by LC-... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5364024

实验名称：AUC (0 to infinity) in Sprague-Dawley rat at 10 mg/kg, ip measured upto 48 hrs by LC-... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5364025

实验名称：AUC (0 to t) in Sprague-Dawley rat at 10 mg/kg, ip measured upto 48 hrs by LC-MS/MS a... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5364022

实验名称：AUC (0 to infinity) in Sprague-Dawley rat at 8 mg/kg, iv measured upto 48 hrs by LC-M... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5364023

实验名称：AUC (0 to t) in Sprague-Dawley rat at 8 mg/kg, iv measured upto 48 hrs by LC-MS/MS an... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5364020

实验名称：AUC (0 to t) in Sprague-Dawley rat at 40 mg/kg, IG measured upto 48 hrs by LC-MS/MS a... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5364021

实验名称：Cytotoxicity against human PBMC cells assessed as reduction in cell viability at 1 to... 来源：ChEMBL 靶标：PBMC External Id：CHEMBL5364018

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