栀子黄素B

• 常用名: 栀子黄素B
• 英文名: Gardenin B
• CAS号: 2798-20-1
• 分子量: 358.342
• 密度: 1.3±0.1 g/cm3
• 沸点: 582.0±50.0 °C at 760 mmHg
• 分子式: C₁₉H₁₈O₇
• 熔点: 180-181ºC
• 闪点: 210.8±23.6 °C

栀子黄素B用途

Gardenin B 是从 Baccharis scandens 中分离出的一种黄酮类化合物。Gardenin B 能诱导人白血病细胞死亡,诱导的凋亡发生与多个 caspases 相关。

栀子黄素B名称

• 中文名: 栀子黄素
• 英文名: gardenin B
• 中文别名: 去甲基桔皮素

栀子黄素B生物活性

• 描述: Gardenin B 是从 Baccharis scandens 中分离出的一种黄酮类化合物。Gardenin B 能诱导人白血病细胞死亡,诱导的凋亡发生与多个 caspases 相关。
• 相关类别:
  信号通路 >> 细胞凋亡 >> 细胞凋亡
  研究领域 >> 癌症
• 参考文献:

  [1]. Cabrera J, et al. Gardenin B-induced cell death in human leukemia cells involves multiple caspases but is independent of the generation of reactive oxygen species. Chem Biol Interact. 2016 Aug 25;256:220-7.

栀子黄素B物理化学性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 582.0±50.0 °C at 760 mmHg
• 熔点: 180-181ºC
• 分子式: C₁₉H₁₈O₇
• 分子量: 358.342
• 闪点: 210.8±23.6 °C
• 精确质量: 358.105255
• PSA: 87.36000
• LogP: 2.27
• InChIKey: LXEVSYZNYDZSOB-UHFFFAOYSA-N
• SMILES: COc1ccc(-c2cc(=O)c3c(O)c(OC)c(OC)c(OC)c3o2)cc1
• 外观性状: 黄色粉末
• 蒸汽压: 0.0±1.7 mmHg at 25°C
• 折射率: 1.593
• 储存条件: 2-8℃，干燥，密闭

栀子黄素B安全信息

• 危害码 (欧洲): Xi

栀子黄素B靶点实验

查看更多实验

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：ERK5 transcriptional activity HTS 来源：24565 靶标：N/A External Id：ERK5 transcriptional activity-HTS

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：Fluorescence polarization to screen for inhibitor that competite the binding of FadD2... 来源：Broad Institute 靶标：FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) External Id：2147-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfect... 来源：Broad Institute 靶标：N/A External Id：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition - 7011-01_Antagonist_SinglePoint_HTS_Activity

实验名称：Antagonist activity at PPARgamma (unknown origin) expressed in human LNCaP cells asse... 来源：ChEMBL 靶标：Peroxisome proliferator-activated receptor gamma External Id：CHEMBL4825254

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify pos... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_PAM_FLUO8_1536_1X%ACT PRUN

实验名称：Fluorescence polarization-based biochemical high throughput primary assay to identify... 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=Sialate O-acetylesterase; AltName: Full=H-Lse; AltName: Full=Sialic acid-specific 9-O-acetylesterase; Flags: Precursor [Homo sapiens] External Id：SIAE_INH_FP_1536_1X%INH PRUN

实验名称：Validation qHTS for agonist of cAMP-regulated guanine nucleotide exchange factor 3 (E... 来源：NCGC External Id：epac1-activator-v

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栀子黄素B英文别名

• 5-Hydroxy-4',6,7,8-tetramethoxyflavone
• Demethyltangeretin
• 5-O-demethyltangeretin
• Gardenin B
• 5-Hydroxy-2-(4-methoxyphenyl)-6,7,8-trimethoxy-4H-1-benzopyran-4-one
• 5-demethyltangeretin
• 5-Hydroxy-6,7,8-trimethoxy-2-(4-methoxyphenyl)-4H-chromen-4-one
• 5-hydroxy-6,7,8,4'-tetramethoxyflavone
• 5-O-Desmethyltangeretin
• 5-Hydroxy-6,7,8-trimethoxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one
• 6,7,8,4'-tetramethoxy-5-hydroxyflavone
• 5-hydroxy-6,7,8-trimethoxy-2-(4-methoxyphenyl)chromen-4-one
• 5-hydroxy-4',6,7,8-tetramethoxy-flavone