INDOMETHACIN ESTER, N-HEPTYL

• 常用名: INDOMETHACIN ESTER, N-HEPTYL
• 英文名: INDOMETHACIN ESTER, N-HEPTYL
• CAS号: 282728-47-6
• 分子量: 455.97
• 密度: 1.2±0.1 g/cm3
• 沸点: 533.6±50.0 °C at 760 mmHg
• 分子式: C₂₆H₃₀ClNO₄
• 熔点: N/A
• 闪点: 276.5±30.1 °C

INDOMETHACIN ESTER, N-HEPTYL用途

吲哚美辛庚酯是一种选择性COX-2抑制剂,IC50为0.04μM,具有抗炎活性[1]。

INDOMETHACIN ESTER, N-HEPTYL名称

• 英文名: Heptyl [1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acet ate

INDOMETHACIN ESTER, N-HEPTYL生物活性

• 描述: 吲哚美辛庚酯是一种选择性COX-2抑制剂,IC50为0.04μM,具有抗炎活性[1]。
• 相关类别:
  研究领域 >> 炎症/免疫
  信号通路 >> 免疫及炎症 >> COX
• 参考文献:

  [1]. A S Kalgutkar, et al. Ester and amide derivatives of the nonsteroidal antiinflammatory drug, indomethacin, as selective cyclooxygenase-2 inhibitors. J Med Chem. 2000 Jul 27;43(15):2860-70.

INDOMETHACIN ESTER, N-HEPTYL物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 533.6±50.0 °C at 760 mmHg
• 分子式: C₂₆H₃₀ClNO₄
• 分子量: 455.97
• 闪点: 276.5±30.1 °C
• 精确质量: 455.186340
• PSA: 57.53000
• LogP: 6.75
• InChIKey: PYBCHCVNKGZCOH-UHFFFAOYSA-N
• SMILES: CCCCCCCOC(=O)Cc1c(C)n(C(=O)c2ccc(Cl)cc2)c2ccc(OC)cc12
• 蒸汽压: 0.0±1.4 mmHg at 25°C
• 折射率: 1.565

INDOMETHACIN ESTER, N-HEPTYL靶点实验

查看更多实验

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实验名称：In vitro inhibitory activity against human Prostaglandin G/H synthase 2 (66 nM) using... 来源：ChEMBL 靶标：Prostaglandin G/H synthase 2 External Id：CHEMBL762913

实验名称：Selectivity ratio of IC50s from COX-1 and COX-2 来源：ChEMBL 靶标：Prostaglandin G/H synthase 1 External Id：CHEMBL838350

实验名称：Cell-based high throughput primary assay to identify activators of GPR151 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=G-protein coupled receptor 151; AltName: Full=G-protein coupled receptor PGR7; AltName: Full=GPCR-2037; AltName: Full=Galanin receptor 4; AltName: Full=Galanin-receptor-like protein; Short=GalRL External Id：GPR151_PHUNTER_AG_LUMI_1536_1X%ACT

实验名称：AlphaScreen-based biochemical high throughput primary assay to identify inhibitors of... 来源：The Scripps Research Institute Molecular Screening Center External Id：MITF_INH_Alpha_1536_1X%INH PRUN

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INDOMETHACIN ESTER, N-HEPTYL英文别名

• Heptyl [1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetate
• 1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-, heptyl ester