2-[1-(4-氯苯甲酰基)-5-甲氧基-2-甲基-1H-吲哚-3-基]-1-(4-吗啉基)乙酮

• 常用名: 2-[1-(4-氯苯甲酰基)-5-甲氧基-2-甲基-1H-吲哚-3-基]-1-(4-吗啉基)乙酮
• 英文名: BML-190
• CAS号: 2854-32-2
• 分子量: 426.893
• 密度: 1.3±0.1 g/cm3
• 沸点: 586.7±50.0 °C at 760 mmHg
• 分子式: C₂₃H₂₃ClN₂O₄
• 熔点: N/A
• 闪点: 308.6±30.1 °C

用途

BML-190(IMMA)是CB2受体的配体,对CB2和CB1受体的Ki分别为435 nM和> 2 μM。

名称

• 中文名: 2-(1-(4-氯苯甲酰基)-5-甲氧基-2-甲基-1H-吲哚-3-基)-1-吗啉乙酮
• 英文名: 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]-1-morpholin-4-ylethanone
• 中文别名: 2-[1-(4-氯苯甲酰基)-5-甲氧基-2-甲基-1H-吲哚-3-基]-1-(4-吗啉基)乙酮

生物活性

• 描述: BML-190(IMMA)是CB2受体的配体,对CB2和CB1受体的Ki分别为435 nM和> 2 μM。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 大麻素受体
  研究领域 >> 癌症
• 参考文献:

  [1]. Zhang, Qiang; Ma, Peng; Cole, Richard B.; Wang, Guangdi In vitro metabolism of indomethacin morpholinylamide (BML-190), an inverse agonist for the peripheral cannabinoid receptor (CB2) in rat liver microsomes. European Journal of Pharmaceutical Sciences (

  [2]. Klegeris, Andis; Bissonnette, Christopher J.; McGeer, Patrick L. Reduction of human monocytic cell neurotoxicity and cytokine secretion by ligands of the cannabinoid-type CB2 receptor. British Journal of Pharmacology (2003), 139(4), 775-786.

  [3]. New DC, Wong YH. BML-190 and AM251 act as inverse agonists at the human cannabinoid CB2 receptor: signalling via cAMP and inositol phosphates. FEBS Lett. 2003 Feb 11;536(1-3):157-60.

物理化学性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 586.7±50.0 °C at 760 mmHg
• 分子式: C₂₃H₂₃ClN₂O₄
• 分子量: 426.893
• 闪点: 308.6±30.1 °C
• 精确质量: 426.134644
• PSA: 60.77000
• LogP: 2.99
• 外观性状: solid | off-white
• 蒸汽压: 0.0±1.6 mmHg at 25°C
• 折射率: 1.625
• 储存条件: 2-8°C
• 水溶解性: DMSO: >20mg/mL

毒性和生态

安全信息

• WGK德国: 3
• 海关编码: 2934999090

海关

• 海关编码: 2934999090
• 中文概述: 2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
• 申报要素: 品名, 成分含量, 用途
• Summary: 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

英文别名

• 2-(1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)-1-morpholinoethanone
• Indomethacin morpholinamide
• Lopac-I-151
• BML-190
• 2-[1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-1-(morpholin-4-yl)ethanone
• Ethanone (2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-1-(4-morpholinyl)
• Tocris-1383
• 2-Methyl-5-methoxy-3-indolyl-essigsaeure-amid
• IMMA
• Indomethacin morpholinylamide
• Ethanone, 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-1-(4-morpholinyl)-
• 2-[1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-1-(4-morpholinyl)ethanone