2854-32-2

• 常用中文名：2-[1-(4-氯苯甲酰基)-5-甲氧基-2-甲基-1H-吲哚-3-基]-1-(4-吗啉基)乙酮
• 常用英文名：BML-190
• CAS号：2854-32-2
• 分子式：C₂₃H₂₃ClN₂O₄
• 分子量：426.893
• 相关类别： 生物化工 抑制剂 G蛋白偶联受体(GPCR & G Protein) Cannabinoid Receptor 激动剂
• 发布时间：2018-12-13 00:18:54
• 更新时间：2026-07-03 16:15:59
• BML-190(IMMA)是CB2受体的配体,对CB2和CB1受体的Ki分别为435 nM和> 2 μM。

名称

• 中文名: 2-(1-(4-氯苯甲酰基)-5-甲氧基-2-甲基-1H-吲哚-3-基)-1-吗啉乙酮
• 英文名: 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]-1-morpholin-4-ylethanone
• 中文别名: 吲哚美辛吗啉代酰胺; 1-(4-吗啉基)-2-[1-(4-甲氧基苯甲酰基)-2-甲基-5-甲氧基-3-吲哚基]乙酮; 吲哚美辛吗啉代酰胺,10 MM DMSO 溶液; BML-190游离态; BML-190,CB 2受体反向激动剂
• 英文别名: Indomethacin morpholinamide; N-[1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-3-indoleacetyl]morpholine; Tocris-1383; 1-(4-CHLOROBENZOYL)-5-METHOXY-2-METHYL-1-[2-(4-MORPHOLINYL)-2-OXOETHYL]-1H-INDOLE; BML-190 ，S2854; BML-190;BML 190;BML; BML-190, N-[1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-3-indoleacetyl]morpholine; 2-[1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-1-(morpholin-4-yl)ethanone; Ethanone (2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-1-(4-morpholinyl); IMMA; 2-(1-(4-chlorobenzoyl)-5-Methoxy-2-Methyl-1H-indol-3-yl)-1-Morpholinoethanone; 1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-3-[2-(4-morpholinyl)-2-oxoethyl]-1H-indole; 2-(1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)-1-morpholinoethanone; 1-(p-chlorobenzoyl)-5-methoxy-2-methyl-3-[(morpholinocbonyl)methyl]-indole; INDOMETHACIN MORPHOLINYLAMIDE; 1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1-[2-(morpholinyl)-2-oxoethyl]-1H-indole; Lopac-I-151; Indomethacin morpholinylamide; 1-(4-CHLOROBENZOYL)-5-METHOXY-2-METHYL-1H-INDOLE-3-ACETIC ACID, MORPHOLINEAMIDE; Ethanone, 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-1-(4-morpholinyl); BML-190 (Indomethacin morpholinylamide; 2-[1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-1-(4-morpholinyl)ethanone; BML 190; BML190; IMMA; INDOMETHACIN MORPHOLINYLAMIDE; BML-190, 10 mM in DMSO; 2-[1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-3-indolyl]-1-morpholinoethanone; 1h-indole,1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1-(2-(4-morpholinyl)-2-oxoe; 4-((2-(p-chlorobenzoyl)-5-methoxy-2-methyl-3-indolyl)acetyl)-morpholin; 2-Methyl-5-methoxy-3-indolyl-essigsaeure-amid; BML-190 //BP; Indomethacin Morpholinylamide Impurity

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 586.7±50.0 °C at 760 mmHg
• 分子式: C₂₃H₂₃ClN₂O₄
• 分子量: 426.893
• 闪点: 308.6±30.1 °C
• 精确质量: 426.134644
• PSA: 60.77000
• LogP: 2.99
• 外观性状: solid | off-white
• 蒸汽压: 0.0±1.6 mmHg at 25°C
• 折射率: 1.625
• 储存条件: 2-8°C
• 水溶解性: DMSO: >20mg/mL

生物活性

• 描述: BML-190(IMMA)是CB2受体的配体,对CB2和CB1受体的Ki分别为435 nM和> 2 μM。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 大麻素受体
  研究领域 >> 癌症
• 参考文献:

  [1]. Zhang, Qiang; Ma, Peng; Cole, Richard B.; Wang, Guangdi In vitro metabolism of indomethacin morpholinylamide (BML-190), an inverse agonist for the peripheral cannabinoid receptor (CB2) in rat liver microsomes. European Journal of Pharmaceutical Sciences (

  [2]. Klegeris, Andis; Bissonnette, Christopher J.; McGeer, Patrick L. Reduction of human monocytic cell neurotoxicity and cytokine secretion by ligands of the cannabinoid-type CB2 receptor. British Journal of Pharmacology (2003), 139(4), 775-786.

  [3]. New DC, Wong YH. BML-190 and AM251 act as inverse agonists at the human cannabinoid CB2 receptor: signalling via cAMP and inositol phosphates. FEBS Lett. 2003 Feb 11;536(1-3):157-60.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : QD9930000 CHEMICAL NAME : Morpholine, 4-((2-(p-chlorobenzoyl)-5-methoxy-2-methyl-3-indolyl) acetyl)- CAS REGISTRY NUMBER : 2854-32-2 LAST UPDATED : 199612 DATA ITEMS CITED : 1 MOLECULAR FORMULA : C23-H23-Cl-N2-O4 MOLECULAR WEIGHT : 426.93 WISWESSER LINE NOTATION : T56 BNJ BVR DG& C1 GO1 D1V- AT6N DOTJ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 40 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 114,309,1975

安全

• WGK德国: 3
• 海关编码: 2934999090

合成路线

110-91-8 53-86-1 ~62% 2854-32-2

文献：Kalgutkar, Amit S.; Marnett, Alan B.; Crews, Brenda C.; Remmel, Rory P.; Marnett, Lawrence J. Journal of Medicinal Chemistry, 2000 , vol. 43, # 15 p. 2860 - 2870

2882-15-7 ~% 2854-32-2

文献：Gallant, Michel; Dufresne, Claude; Gareau, Yves; Guay, Daniel; Leblanc, Yves; Prasit, Petpiboon; Rochette, Chantal; Sawyer, Nicole; Slipetz, Deborah M.; Tremblay, Nathalie; Metters, Kathleen M.; Labelle, Marc Bioorganic and Medicinal Chemistry Letters, 1996 , vol. 6, # 19 p. 2263 - 2268

122-01-0 180002-77-1 ~% 2854-32-2

文献：Gallant, Michel; Dufresne, Claude; Gareau, Yves; Guay, Daniel; Leblanc, Yves; Prasit, Petpiboon; Rochette, Chantal; Sawyer, Nicole; Slipetz, Deborah M.; Tremblay, Nathalie; Metters, Kathleen M.; Labelle, Marc Bioorganic and Medicinal Chemistry Letters, 1996 , vol. 6, # 19 p. 2263 - 2268

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110-91-8 53-86-1 2882-15-7 122-01-0
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海关

海关编码	2934999090
中文概述	2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%