2854-32-2

2854-32-2结构式

常用中文名：2-[1-(4-氯苯甲酰基)-5-甲氧基-2-甲基-1H-吲哚-3-基]-1-(4-吗啉基)乙酮
常用英文名：BML-190
CAS号：2854-32-2
分子式：C₂₃H₂₃ClN₂O₄
分子量：426.893
相关类别：生物化工抑制剂 G蛋白偶联受体(GPCR & G Protein) Cannabinoid Receptor 激动剂
发布时间：2018-12-13 00:18:54
更新时间：2024-01-24 12:02:53
BML-190(IMMA)是CB2受体的配体,对CB2和CB1受体的Ki分别为435 nM和> 2 μM。

化源商城直购

中文名	2-(1-(4-氯苯甲酰基)-5-甲氧基-2-甲基-1H-吲哚-3-基)-1-吗啉乙酮
英文名	2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]-1-morpholin-4-ylethanone
中文别名	2-[1-(4-氯苯甲酰基)-5-甲氧基-2-甲基-1H-吲哚-3-基]-1-(4-吗啉基)乙酮
英文别名	2-(1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)-1-morpholinoethanone Indomethacin morpholinamide Lopac-I-151 BML-190 2-[1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-1-(morpholin-4-yl)ethanone Ethanone (2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-1-(4-morpholinyl) Tocris-1383 2-Methyl-5-methoxy-3-indolyl-essigsaeure-amid IMMA Indomethacin morpholinylamide Ethanone, 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-1-(4-morpholinyl)- 2-[1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-1-(4-morpholinyl)ethanone

描述	BML-190(IMMA)是CB2受体的配体,对CB2和CB1受体的Ki分别为435 nM和> 2 μM。
相关类别	信号通路 >> G 蛋白偶联受体/G 蛋白 >> 大麻素受体研究领域 >> 癌症
参考文献	[1]. Zhang, Qiang; Ma, Peng; Cole, Richard B.; Wang, Guangdi In vitro metabolism of indomethacin morpholinylamide (BML-190), an inverse agonist for the peripheral cannabinoid receptor (CB2) in rat liver microsomes. European Journal of Pharmaceutical Sciences ( [2]. Klegeris, Andis; Bissonnette, Christopher J.; McGeer, Patrick L. Reduction of human monocytic cell neurotoxicity and cytokine secretion by ligands of the cannabinoid-type CB2 receptor. British Journal of Pharmacology (2003), 139(4), 775-786. [3]. New DC, Wong YH. BML-190 and AM251 act as inverse agonists at the human cannabinoid CB2 receptor: signalling via cAMP and inositol phosphates. FEBS Lett. 2003 Feb 11;536(1-3):157-60.

密度	1.3±0.1 g/cm3
沸点	586.7±50.0 °C at 760 mmHg
分子式	C₂₃H₂₃ClN₂O₄
分子量	426.893
闪点	308.6±30.1 °C
精确质量	426.134644
PSA	60.77000
LogP	2.99
外观性状	solid \| off-white
蒸汽压	0.0±1.6 mmHg at 25°C
折射率	1.625
储存条件	2-8°C
水溶解性	DMSO: >20mg/mL

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QD9930000

CHEMICAL NAME :: Morpholine, 4-((2-(p-chlorobenzoyl)-5-methoxy-2-methyl-3-indolyl) acetyl)-

CAS REGISTRY NUMBER :: 2854-32-2

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C23-H23-Cl-N2-O4

MOLECULAR WEIGHT :: 426.93

WISWESSER LINE NOTATION :: T56 BNJ BVR DG& C1 GO1 D1V- AT6N DOTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 40 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 114,309,1975

WGK德国	3
海关编码	2934999090

110-91-8

53-86-1

~62%

2854-32-2

文献：Kalgutkar, Amit S.; Marnett, Alan B.; Crews, Brenda C.; Remmel, Rory P.; Marnett, Lawrence J. Journal of Medicinal Chemistry, 2000 , vol. 43, # 15 p. 2860 - 2870

2882-15-7

2854-32-2

文献：Gallant, Michel; Dufresne, Claude; Gareau, Yves; Guay, Daniel; Leblanc, Yves; Prasit, Petpiboon; Rochette, Chantal; Sawyer, Nicole; Slipetz, Deborah M.; Tremblay, Nathalie; Metters, Kathleen M.; Labelle, Marc Bioorganic and Medicinal Chemistry Letters, 1996 , vol. 6, # 19 p. 2263 - 2268

122-01-0

180002-77-1

2854-32-2

上游产品 4
110-91-8 53-86-1 2882-15-7 122-01-0
下游产品 0

海关编码	2934999090
中文概述	2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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