NK3R-IN-1

更新时间：2025-09-19 14:11:46

NK3R-IN-1用途

NK3R-IN-1(化合物16x)是咪唑吡嗪衍生物,是一种口服活性神经激肽受体NK3R抑制剂。NK3R-IN-1降低卵巢切除术(OVX)模型中的血液促黄体生成素水平[1]。

英文名	NK3R-IN-1

描述	NK3R-IN-1(化合物16x)是咪唑吡嗪衍生物,是一种口服活性神经激肽受体NK3R抑制剂。NK3R-IN-1降低卵巢切除术(OVX)模型中的血液促黄体生成素水平[1]。
相关类别	研究领域 >> 内分泌信号通路 >> 神经信号通路 >> 神经激肽受体信号通路 >> G 蛋白偶联受体/G 蛋白 >> 神经激肽受体
参考文献	[1]. Ye L, et al. Synthesis and evaluation of piperazinotriazoles. Discovery of a potent and orally bioavailable neurokinin-3 receptor inhibitor. Eur J Med Chem. 2023 Sep 5;257:115486.

分子式	C₁₇H₁₆FN₅OS
分子量	357.41

实验名称：Apparent permeability across apical to basolateral side in human Caco-2 cells incubat...
来源：ChEMBL
靶标：N/A
External Id：CHEMBL5621455

实验名称：Apparent permeability across basolateral to apical side in human Caco-2 cells incubat...
来源：ChEMBL
靶标：N/A
External Id：CHEMBL5621456

实验名称：Efflux ratio of apparent permeability across basolateral to apical side over apical t...
来源：ChEMBL
靶标：N/A
External Id：CHEMBL5621457

实验名称：Metabolic stability in rat liver microsomes assessed as intrinsic clearance incubated...
来源：ChEMBL
靶标：N/A
External Id：CHEMBL5621458

实验名称：Metabolic stability in human liver microsomes assessed as intrinsic clearance incubat...
来源：ChEMBL
靶标：N/A
External Id：CHEMBL5621459

实验名称：Tmax in Sprague-Dawley rat at 5 mg/kg, IG measured upto 24 hrs by LC-MS analysis
来源：ChEMBL
靶标：N/A
External Id：CHEMBL5621460

实验名称：AUClast in Sprague-Dawley rat at 1 mg/kg, iv measured upto 24 hrs by LC-MS analysis
来源：ChEMBL
靶标：N/A
External Id：CHEMBL5621463

实验名称：AUClast in Sprague-Dawley rat at 5 mg/kg, IG measured upto 24 hrs by LC-MS analysis
来源：ChEMBL
靶标：N/A
External Id：CHEMBL5621464

实验名称：Clearance in Sprague-Dawley rat at 1 mg/kg, iv measured upto 24 hrs by LC-MS analysis
来源：ChEMBL
靶标：N/A
External Id：CHEMBL5621465

实验名称：Observed apparent volume of distribution in Sprague-Dawley rat at 1 mg/kg, iv measure...
来源：ChEMBL
靶标：N/A
External Id：CHEMBL5621466

共14条，当前第1页，共2页