Y型320

• 常用名: Y型320
• 英文名: Y-320
• CAS号: 288250-47-5
• 分子量: 505.011
• 密度: 1.3±0.1 g/cm3
• 沸点: 631.2±55.0 °C at 760 mmHg
• 分子式: C₂₇H₂₉ClN₆O₂
• 熔点: N/A
• 闪点: 335.6±31.5 °C

Y型320用途

Y-320是免疫调节剂,能抑制IL-15刺激CD4 T细胞后的IL-17生成,IC50为20到60 nM。

Y型320名称

• 中文名: Y型320
• 英文名: 1-(4-chlorophenyl)-N-[3-cyano-4-(4-morpholinopiperidin-1-yl)phenyl]-5-methylpyrazole-4-carboxamide

Y型320生物活性

• 描述: Y-320是免疫调节剂,能抑制IL-15刺激CD4 T细胞后的IL-17生成,IC50为20到60 nM。
• 相关类别:
  信号通路 >> 免疫及炎症 >> 白细胞介素相关
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Ushio H, et al. A new phenylpyrazoleanilide, y-320, inhibits interleukin 17 production and ameliorates collagen-induced arthritis in mice and cynomolgus monkeys. Pharmaceuticals (Basel). 2013 Dec 23;7(1):1-17.

Y型320物理化学性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 631.2±55.0 °C at 760 mmHg
• 分子式: C₂₇H₂₉ClN₆O₂
• 分子量: 505.011
• 闪点: 335.6±31.5 °C
• 精确质量: 504.204041
• PSA: 86.42000
• LogP: 3.58
• InChIKey: BWZNJVZTAWBIFG-UHFFFAOYSA-N
• SMILES: Cc1c(C(=O)Nc2ccc(N3CCC(N4CCOCC4)CC3)c(C#N)c2)cnn1-c1ccc(Cl)cc1
• 外观性状: white solid
• 蒸汽压: 0.0±1.8 mmHg at 25°C
• 折射率: 1.675
• 储存条件: -20℃

Y型320靶点实验

查看更多实验

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

实验名称：Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu... 来源：NCGC External Id：CYP2D6395

实验名称：Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu... 来源：NCGC External Id：CYP2C9536

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL4495582

实验名称：Cytochrome P450 family 3 subfamily A member 7 (CYP3A7) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A7681

实验名称：Enzymatic assay of human HDAC6 with commercial peptide substrate 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808149

实验名称：Enzymatic assay of human HDAC6 with custom peptide substrate 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808150

实验名称：Primary qHTS for inhibitors of NSP2Pro chikungunya virus (CHIKV) 来源：NCGC External Id：APP-Toga-CHIKV-nsp2-p

实验名称：qHTS assay to identify novel small-molecules to repurpose for Merkel cell carcinoma t... 来源：NCGC 靶标：N/A External Id：MCC011

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Y型320英文别名

• 1-(4-Chlorophenyl)-N-{3-cyano-4-[4-(4-morpholinyl)-1-piperidinyl]phenyl}-5-methyl-1H-pyrazole-4-carboxamide
• 1-(4-Chlorophenyl)-N-(3-cyano-4-(4-morpholinopiperidin-1-yl)phenyl)-5-methyl-1H-pyrazole-4-carboxamide
• Y320
• Y-320