阿伏生

• 常用名: 阿伏生
• 英文名: Avosentan
• CAS号: 290815-26-8
• 分子量: 479.508
• 密度: 1.4±0.1 g/cm3
• 沸点: 575.5±60.0 °C at 760 mmHg
• 分子式: C₂₃H₂₁N₅O₅S
• 熔点: N/A
• 闪点: 301.8±32.9 °C

阿伏生用途

Avosentan(Ro 67-0565; SPP-301)是内皮素(ETA)受体拮抗剂。

阿伏生名称

• 中文名: N-[6-甲氧基-5-(2-甲氧基苯氧基)-2-(4-吡啶基)-4-嘧啶基]-5-甲基吡啶-2-磺酰胺
• 英文名: N-[6-methoxy-5-(2-methoxyphenoxy)-2-pyridin-4-ylpyrimidin-4-yl]-5-methylpyridine-2-sulfonamide

阿伏生生物活性

• 描述: Avosentan(Ro 67-0565; SPP-301)是内皮素(ETA)受体拮抗剂。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 内皮素受体
  研究领域 >> 心血管疾病
• 参考文献:

  [1]. Baltatu OC, Iliescu R, Zaugg CE, Reckelhoff JF, Louie P, Schumacher C, Campos LA. Antidiuretic effects of the endothelin receptor antagonist avosentan. Front Physiol. 2012;3:103.

  [2]. Konieczka K, Meyer P, Schoetzau A, Neutzner A, Mozaffarieh M, Flammer J. Effect of avosentan (SPP-301) in porcine ciliary arteries. Curr Eye Res. 2011 Feb;36(2):118-24.

  [3]. Mann JF, Green D, Jamerson K, Ruilope LM, Kuranoff SJ, Littke T, Viberti G; ASCEND Study Group. J Am Soc Nephrol. 2010 Mar;21(3):527-35.

  [4]. Dieterle W, Hengelage T. Absolute bioavailability and pharmacokinetics of avosentan in man. Int J Clin Pharmacol Ther. 2009 Sep;47(9):587-94.

  [5]. Effect of SPP 301, an Endothelin Antagonist, on Intraocular Pressure in Glaucomatous Monkey Eyes By Wang, Rong-Fang; Podos, Steven M.; Serle, Janet B.; Baltatu, Ovidiu C. From Current Eye Research (2011), 36(1), 41-46.

阿伏生物理化学性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 575.5±60.0 °C at 760 mmHg
• 分子式: C₂₃H₂₁N₅O₅S
• 分子量: 479.508
• 闪点: 301.8±32.9 °C
• 精确质量: 479.126343
• PSA: 133.80000
• LogP: 0.87
• InChIKey: YBWLTKFZAOSWSM-UHFFFAOYSA-N
• SMILES: COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(-c2ccncc2)nc1OC
• 蒸汽压: 0.0±1.6 mmHg at 25°C
• 折射率: 1.621
• 储存条件: 2-8℃

阿伏生靶点实验

查看更多实验

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

实验名称：Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu... 来源：NCGC External Id：CYP2D6395

实验名称：Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu... 来源：NCGC External Id：CYP2C9536

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL4495582

实验名称：Cytochrome P450 family 3 subfamily A member 7 (CYP3A7) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A7681

实验名称：Enzymatic assay of human HDAC6 with commercial peptide substrate 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808149

实验名称：Enzymatic assay of human HDAC6 with custom peptide substrate 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808150

实验名称：Primary qHTS for inhibitors of NSP2Pro chikungunya virus (CHIKV) 来源：NCGC External Id：APP-Toga-CHIKV-nsp2-p

实验名称：A screen for small molecules that modulate mitochondrial supercomplex formation 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：N/A External Id：HMS1482

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阿伏生英文别名

• Avosentan
• UNII-L94KSX715K
• N-[6-Methoxy-5-(2-methoxyphenoxy)-2-(4-pyridinyl)-4-pyrimidinyl]-5-methyl-2-pyridinesulfonamide
• Ro 67-0565
• SPP301