HDAC-IN-63

• 常用名: HDAC-IN-63
• 英文名: HDAC-IN-63
• CAS号: 2920046-95-1
• 分子量: 529.42
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₅H₂₆Cl₂N₆O₃
• 熔点: N/A
• 闪点: N/A

HDAC-IN-63用途

HDAC-IN-63 (Compound 63) 是一种双重 FLT3/HDAC 抑制剂 (IC50: 对 FLT3 和 HDAC1 分别为 0.844 和 30.0 nM)。HDAC-IN-63 抑制 MV4-11 细胞增殖 (IC50: 92 nM。HDAC-IN-63在 MV4-11 细胞中诱导细胞凋亡 (apoptosis) 并阻滞细胞周期。HDAC-IN-63 可用于急性髓系白血病 (AML) 的研究。

HDAC-IN-63名称

• 英文名: HDAC-IN-63

HDAC-IN-63生物活性

• 描述: HDAC-IN-63 (Compound 63) 是一种双重 FLT3/HDAC 抑制剂 (IC50: 对 FLT3 和 HDAC1 分别为 0.844 和 30.0 nM)。HDAC-IN-63 抑制 MV4-11 细胞增殖 (IC50: 92 nM。HDAC-IN-63在 MV4-11 细胞中诱导细胞凋亡 (apoptosis) 并阻滞细胞周期。HDAC-IN-63 可用于急性髓系白血病 (AML) 的研究。
• 相关类别:
  信号通路 >> 细胞凋亡 >> 细胞凋亡
  研究领域 >> 癌症
  信号通路 >> 蛋白酪氨酸激酶 >> FLT3
  信号通路 >> 细胞周期/DNA损伤 >> HDAC
  信号通路 >> 表观遗传学 >> HDAC
• 靶点实验:

  0.844 and 30.0 nM for FLT3 and HDAC1[1]

• 参考文献:

  [1]. Wang Z, et al. Rational discovery of dual FLT3/HDAC inhibitors as a potential AML therapy. Eur J Med Chem. 2023 Aug 28;260:115759.

HDAC-IN-63物理化学性质

• 分子式: C₂₅H₂₆Cl₂N₆O₃
• 分子量: 529.42

HDAC-IN-63靶点实验

查看更多实验

实验名称：Inhibition of HDAC2 (unknown origin) at 1 uM using RHKK(Ac)AMC as substrate preincuba... 来源：ChEMBL 靶标：Histone deacetylase 2 External Id：CHEMBL5628817

实验名称：Inhibition of HDAC3 (unknown origin) at 1 uM using RHKK(Ac)AMC as substrate preincuba... 来源：ChEMBL 靶标：Histone deacetylase 3 External Id：CHEMBL5628818

实验名称：Inhibition of HDAC4 (unknown origin) at 1 uM using boc-(trifluoroacetyl)lysineAMC as ... 来源：ChEMBL 靶标：Histone deacetylase 4 External Id：CHEMBL5628819

实验名称：Inhibition of HDAC6 (unknown origin) at 1 uM using RHKK(Ac)AMC as substrate preincuba... 来源：ChEMBL 靶标：Protein deacetylase HDAC6 External Id：CHEMBL5628820

实验名称：Inhibition of HDAC7 (unknown origin) at 1 uM using boc-(trifluoroacetyl)lysineAMC as ... 来源：ChEMBL 靶标：Histone deacetylase 7 External Id：CHEMBL5628821

实验名称：Inhibition of HDAC8 (unknown origin) at 1 uM using RHK(Ac)K(Ac)AMC as substrate prein... 来源：ChEMBL 靶标：Histone deacetylase 8 External Id：CHEMBL5628822

实验名称：Inhibition of HDAC11 (unknown origin) at 1 uM using boc-(trifluoroacetyl)lysineAMC as... 来源：ChEMBL 靶标：Histone deacetylase 11 External Id：CHEMBL5628823

实验名称：Inhibition of FLT3 in human MV4-11 cells assessed as decrease in FLT3 phosphorylation... 来源：ChEMBL 靶标：Receptor-type tyrosine-protein kinase FLT3 External Id：CHEMBL5628831

实验名称：Inhibition of FLT3 in human MV4-11 cells assessed as decrease in STAT5 phosphorylatio... 来源：ChEMBL 靶标：Receptor-type tyrosine-protein kinase FLT3 External Id：CHEMBL5628832

实验名称：Inhibition of FLT3 in human MV4-11 cells assessed as decrease in AKT phosphorylation ... 来源：ChEMBL 靶标：Receptor-type tyrosine-protein kinase FLT3 External Id：CHEMBL5628833

共48条，当前第1页，共5页

1

2

3

4

5