Anti-inflammatory agent 54

• 常用名: Anti-inflammatory agent 54
• 英文名: Anti-inflammatory agent 54
• CAS号: 2924156-46-5
• 分子量: 328.32
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₇H₁₆N₂O₅
• 熔点: N/A
• 闪点: N/A

Anti-inflammatory agent 54用途

Anti-inflammatory agent 54 (compound 9c) 是薏苡醇 (Coixol) 的衍生物,具有抗炎活性。Anti-inflammatory agent 54 抑制 NF-κB 通路,下调 iNOS、TNF-α、IL-6 和 IL-1β 的表达。Anti-inflammatory agent 54 可抑制 LPS 诱导的 RAW264.7 巨噬细胞中一氧化氮 (NO) 产生 (IC50: 2.4 μM),在小鼠耳廓水肿模型中发挥体内抗炎活性。

Anti-inflammatory agent 54名称

• 英文名: Anti-inflammatory agent 54

Anti-inflammatory agent 54生物活性

• 描述: Anti-inflammatory agent 54 (compound 9c) 是薏苡醇 (Coixol) 的衍生物,具有抗炎活性。Anti-inflammatory agent 54 抑制 NF-κB 通路,下调 iNOS、TNF-α、IL-6 和 IL-1β 的表达。Anti-inflammatory agent 54 可抑制 LPS 诱导的 RAW264.7 巨噬细胞中一氧化氮 (NO) 产生 (IC50: 2.4 μM),在小鼠耳廓水肿模型中发挥体内抗炎活性。
• 相关类别:
  信号通路 >> 免疫及炎症 >> 白细胞介素相关
  信号通路 >> 免疫及炎症 >> 一氧化氮合酶
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Cui E, et al. Discovery of Coixol Derivatives as Potent Anti-inflammatory Agents. J Nat Prod. 2023 Aug 25;86(8):1950-1959..

Anti-inflammatory agent 54物理化学性质

• 分子式: C₁₇H₁₆N₂O₅
• 分子量: 328.32

Anti-inflammatory agent 54靶点实验

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实验名称：Antiinflammatory activity in ICR mouse model of xylene-induced auricle edema assessed... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL5372136

实验名称：Antiinflammatory activity in ICR mouse model of xylene-induced auricle edema assessed... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL5372137

实验名称：Antiinflammatory activity in ICR mouse model of xylene-induced auricle edema assessed... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL5372134

实验名称：Antiinflammatory activity in ICR mouse model of xylene-induced auricle edema assessed... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL5372135

实验名称：Antiinflammatory activity in ICR mouse model of xylene-induced auricle edema assessed... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL5372132

实验名称：Antiinflammatory activity in ICR mouse model of xylene-induced auricle edema assessed... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL5372133

实验名称：Antiinflammatory activity in ICR mouse model of xylene-induced auricle edema assessed... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL5372130

实验名称：Antiinflammatory activity in ICR mouse model of xylene-induced auricle edema assessed... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL5372131

实验名称：Antiinflammatory activity in LPS-induced mouse RAW264.7 cells assessed as inhibition ... 来源：ChEMBL 靶标：RAW264.7 External Id：CHEMBL5372124

实验名称：Cytotoxicity against mouse RAW264.7 cells incubated for 24 hrs by MTT assay 来源：ChEMBL 靶标：RAW264.7 External Id：CHEMBL5372122

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