WAY 170523

• 常用名: WAY 170523
• 英文名: WAY 170523
• CAS号: 307002-73-9
• 分子量: 613.68
• 密度: 1.352g/cm3
• 沸点: N/A
• 分子式: C₃₃H₃₁N₃O₇S
• 熔点: N/A
• 闪点: N/A

WAY 170523用途

WAY-170523是一种有效的选择性MMP-13(基质金属蛋白酶-13)抑制剂,IC50为17 nM。WAY-170523可直接减弱ERK1/2磷酸化。WAY-170523抑制PC-3细胞的侵袭,可用于前列腺癌研究[1][2]。

WAY 170523名称

• 英文名: WAY 170523,N-[2-[4-[[[2-[(Hydroxyamino)carbonyl]-4,6-dimethylphenyl](phenylmethyl)amino]sulfonyl]phenoxy]ethyl]-2-benzofurancarboxamide

WAY 170523生物活性

• 描述: WAY-170523是一种有效的选择性MMP-13(基质金属蛋白酶-13)抑制剂,IC50为17 nM。WAY-170523可直接减弱ERK1/2磷酸化。WAY-170523抑制PC-3细胞的侵袭,可用于前列腺癌研究[1][2]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 代谢酶/蛋白酶 >> MMP
• 靶点实验:

  MMP13:17 nM (IC50)

  MMP-1:10 μM (IC50)

  MMP-9:945 nM (IC50)

• 体外研究: WAY-170523对MMP-13的IC50为17 nM,对MMP-I、MMP-9和TACE的选择性分别为5800、56和500倍以上。
• 参考文献:

  [1]. James M. Chen, et al. Structure-Based Design of a Novel, Potent, and Selective Inhibitor for MMP-13 Utilizing NMR Spectroscopy and Computer-Aided Molecular Design. J. Am. Chem. Soc. 2000, 122, 40, 9648-9654.

  [2]. Mervi Toriseva, et al. Phenotypic screening using AMIDA identifies different drug responses in breast and prostate cancer cell lines in an organotypic cell culture model. Cancer Res (2018) 78 (13_Supplement): 1158.

WAY 170523物理化学性质

• 密度: 1.352g/cm3
• 分子式: C₃₃H₃₁N₃O₇S
• 分子量: 613.68
• 精确质量: 613.18800
• PSA: 146.56000
• LogP: 7.23550
• InChIKey: FARMEEAGJWMFSZ-UHFFFAOYSA-N
• SMILES: Cc1cc(C)c(N(Cc2ccccc2)S(=O)(=O)c2ccc(OCCNC(=O)c3cc4ccccc4o3)cc2)c(C(=O)NO)c1
• 折射率: 1.656

WAY 170523安全信息

• 危险品运输编码: NONH for all modes of transport

WAY 170523靶点实验

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