地塞米松 21-磷酸

• 常用名: 地塞米松 21-磷酸
• 英文名: Dexamethasone Phosphate
• CAS号: 312-93-6
• 分子量: 472.44100
• 密度: 1.45g/cm3
• 沸点: 669.6ºC at 760mmHg
• 分子式: C₂₂H₃₀FO₈P
• 熔点: 154-157°C (lit.)
• 闪点: 358.7ºC

地塞米松 21-磷酸用途

Dexamethasone phosphate (Dexamethasone 21-phosphate) 是一种无生物活性的化合物,可通过红细胞内酶进行去磷酸化。活性代谢物地塞米松随后通过细胞膜的简单被动扩散释放到循环中。Dexamethasone phosphate 包裹的红细胞具有用于类固醇依赖性溃疡性结肠炎研究的潜力。

地塞米松 21-磷酸名称

• 中文名: 地塞米松磷酸酯
• 英文名: dexamethasone phosphate

地塞米松 21-磷酸生物活性

• 描述: Dexamethasone phosphate (Dexamethasone 21-phosphate) 是一种无生物活性的化合物,可通过红细胞内酶进行去磷酸化。活性代谢物地塞米松随后通过细胞膜的简单被动扩散释放到循环中。Dexamethasone phosphate 包裹的红细胞具有用于类固醇依赖性溃疡性结肠炎研究的潜力。
• 相关类别:
  研究领域 >> 炎症/免疫
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 糖皮质激素受体
• 参考文献:

  [1]. Fabrizio Bossa, et al. Erythrocytes-mediated delivery of dexamethasone 21-phosphate in steroid-dependent ulcerative colitis: a randomized, double-blind Sham-controlled study. Inflamm Bowel Dis. 2013 Aug;19(9):1872-9.

地塞米松 21-磷酸物理化学性质

• 密度: 1.45g/cm3
• 沸点: 669.6ºC at 760mmHg
• 熔点: 154-157°C (lit.)
• 分子式: C₂₂H₃₀FO₈P
• 分子量: 472.44100
• 闪点: 358.7ºC
• 精确质量: 472.16600
• PSA: 151.17000
• LogP: 2.01270
• InChIKey: VQODGRNSFPNSQE-CXSFZGCWSA-N
• SMILES: CC1CC2C3CCC4=CC(=O)C=CC4(C)C3(F)C(O)CC2(C)C1(O)C(=O)COP(=O)(O)O
• 外观性状: 白色至浅棕色固体
• 折射率: 1.594
• 储存条件: 通风低温干燥

地塞米松 21-磷酸毒性和生态

地塞米松 21-磷酸安全信息

• 危害码 (欧洲): Xn
• 风险声明 (欧洲): 62
• 海关编码: 2937290090

地塞米松 21-磷酸海关

• 海关编码: 2937290090

地塞米松 21-磷酸靶点实验

查看更多实验

实验名称：Binding affinity towards human ADRA2A in an in vitro assay with cellular components m... 来源：ChEMBL 靶标：Alpha-2A adrenergic receptor External Id：CHEMBL5291736

实验名称：Binding affinity towards human GABRA1 in an in vitro assay with cellular components m... 来源：ChEMBL 靶标：Gamma-aminobutyric acid receptor subunit gamma-2 External Id：CHEMBL5291799

实验名称：Binding affinity towards human PGR in an in vitro assay with cellular components meas... 来源：ChEMBL 靶标：Progesterone receptor External Id：CHEMBL5291863

实验名称：Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluor... 来源：ChEMBL 靶标：Alpha-1A adrenergic receptor External Id：CHEMBL5291731

实验名称：Binding affinity towards human ESR1 in an in vitro cell free assay (CRO assay) measur... 来源：ChEMBL 靶标：Estrogen receptor External Id：CHEMBL5291792

实验名称：Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with ... 来源：ChEMBL 靶标：Adenosine receptor A3 External Id：CHEMBL5291728

实验名称：Compound was evaluated for inhibition of human PDE3A in an in vitro cell free assay m... 来源：ChEMBL 靶标：cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A External Id：CHEMBL5291856

实验名称：Binding affinity towards human OPRM1 in an in vitro assay with cellular components me... 来源：ChEMBL 靶标：Mu-type opioid receptor External Id：CHEMBL5291855

实验名称：Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured... 来源：ChEMBL 靶标：Alpha-1A adrenergic receptor External Id：CHEMBL5291730

实验名称：Compound was evaluated for inhibition of human F2 in an in vitro cell free assay meas... 来源：ChEMBL 靶标：Prothrombin External Id：CHEMBL5291794

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地塞米松 21-磷酸英文别名

• Hexadrol phosphate
• dexamethasone-21-phosphate
• Dexamethasone 21-orthophosphate
• Betnelan phosphate
• Dexamethasone-21-dihydrogen-phosphate
• Wymesone
• Neodecadron
• Oradexon phosphate
• Dexamethasone phosphate
• [2-[(8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] dihydrogen phosphate