HLI-98C

• 常用名: HLI-98C
• 英文名: HLI-98C
• CAS号: 317326-90-2
• 分子量: 368.73100
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₇H₉ClN₄O₄
• 熔点: N/A
• 闪点: N/A

HLI-98C用途

HLI98C 是一种泛素连接酶抑制剂。HLI98C 抑制 p53 泛素化。HLI98C 抑制 HDM2 自泛素化。

HLI-98C名称

• 英文名: 10-(3-chlorophenyl)-7-nitropyrimido[4,5-b]quinoline-2,4-dione

HLI-98C生物活性

• 描述: HLI98C 是一种泛素连接酶抑制剂。HLI98C 抑制 p53 泛素化。HLI98C 抑制 HDM2 自泛素化。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 细胞凋亡 >> MDM-2/p53
  信号通路 >> 代谢酶/蛋白酶 >> E1/E2/E3酶
• 靶点实验:

  ubiquitin ligase[1]

• 参考文献:

  [1]. Yang Y, et al. Small molecule inhibitors of HDM2 ubiquitin ligase activity stabilize and activate p53 in cells. Cancer Cell. 2005 Jun;7(6):547-59.

HLI-98C物理化学性质

• 分子式: C₁₇H₉ClN₄O₄
• 分子量: 368.73100
• 精确质量: 368.03100
• PSA: 113.57000
• LogP: 3.31200
• InChIKey: BRCGPVHRBGGGPW-UHFFFAOYSA-N
• SMILES: O=c1nc2n(-c3cccc(Cl)c3)c3ccc([N+](=O)[O-])cc3cc-2c(=O)[nH]1

HLI-98C靶点实验

查看更多实验

实验名称：Stabilization of p53 in RPE cells at 1 uM after 24 hrs by Western blotting 来源：ChEMBL 靶标：Cellular tumor antigen p53 External Id：CHEMBL904416

实验名称：Stabilization of p53 in RPE cells at 5 to 10 uM after 24 hrs by Western blotting rela... 来源：ChEMBL 靶标：Cellular tumor antigen p53 External Id：CHEMBL904417

实验名称：Stabilization of p53 level in RKO cells 来源：ChEMBL 靶标：RKO External Id：CHEMBL904418

实验名称：Induction of p21WAF1/CIP1 level in RPE cells 来源：ChEMBL 靶标：N/A External Id：CHEMBL904419

实验名称：Induction of apoptosis in RKO/E6 cells 来源：ChEMBL 靶标：N/A External Id：CHEMBL904424

实验名称：Alphascreen assay for small molecules abrogating mHTT-CaM Interaction 来源：24983 靶标：Huntingtin External Id：KUHTS-Muma KU-CaM-Htt INH-01

实验名称：Cell cycle arrest in RKO cells by accumulation at G1 phase 来源：ChEMBL 靶标：RKO External Id：CHEMBL904420

实验名称：Cell-based high throughput primary assay to identify activators of GPR151 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=G-protein coupled receptor 151; AltName: Full=G-protein coupled receptor PGR7; AltName: Full=GPCR-2037; AltName: Full=Galanin receptor 4; AltName: Full=Galanin-receptor-like protein; Short=GalRL External Id：GPR151_PHUNTER_AG_LUMI_1536_1X%ACT

实验名称：AlphaScreen-based biochemical high throughput primary assay to identify activators of... 来源：The Scripps Research Institute Molecular Screening Center 靶标：N/A External Id：FBW7_ACT_ALPHA_1536_1X%ACT PRUN

实验名称：AlphaScreen-based biochemical high throughput primary assay to identify inhibitors of... 来源：The Scripps Research Institute Molecular Screening Center External Id：MITF_INH_Alpha_1536_1X%INH PRUN

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HLI-98C英文别名

• HLI-98C