BLT-1

更新时间：2024-01-08 18:49:49

BLT-1结构式	常用名	BLT-1	英文名	BLT-1
	CAS号	321673-30-7	分子量	241.39600
	密度	1.14±0.1 g/cm3	沸点	359.6±25.0 °C
	分子式	C₁₂H₂₃N₃S	熔点	N/A
	MSDS	美版	闪点	N/A

BLT-1用途

BLT-1 是一种硫半碳杂铜螯合剂,选择性清道夫受体 B1 型 (SR-BI) 抑制剂。BLT-1 抑制 SR-BI 介导的脂质在高密度脂蛋白 (HDL) 和细胞之间的转移。BLT-1 通过中性粒细胞募集而具有促炎功能。

中文名	2-(2-己基环戊亚基)肼硫代甲酰胺
英文名	[(E)-(2-hexylcyclopentylidene)amino]thiourea
英文别名	更多

描述	BLT-1 是一种硫半碳杂铜螯合剂,选择性清道夫受体 B1 型 (SR-BI) 抑制剂。BLT-1 抑制 SR-BI 介导的脂质在高密度脂蛋白 (HDL) 和细胞之间的转移。BLT-1 通过中性粒细胞募集而具有促炎功能。
相关类别	信号通路 >> 其他 >> 其他研究领域 >> 炎症/免疫
体外研究	BLT-1对ldlA[mSR-BI]细胞的细胞DiI-HDL和[3H]CE-HDL摄取具有60和110nm的IC50s。BLT-1(50μM；3h)在HeLa,BSC-1细胞中不诱导氯氰菊酯依赖性和非依赖性细胞膜运输的一般缺陷[1]。BLT-1能抑制M SR-BI-t1脂质体在细胞(IC50=0.057μM)和脂质体(IC50=0.098μM)中对[3H]CE-HDL的SR-BI依赖性选择性摄取[3H]CE。
参考文献	[1]. Nieland TJ, et al. Discovery of chemical inhibitors of the selective transfer of lipids mediated by the HDL receptorSR-BI. Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15422-7. [2]. Nieland TJ, et al. Identification of the molecular target of small molecule inhibitors of HDL receptor SR-BI activity. Biochemistry. 2008 Jan 8;47(1):460-72. [3]. Raldúa D, et al. BLT-1, a specific inhibitor of the HDL receptor SR-BI, induces a copper-dependent phenotype during zebrafish development. Toxicol Lett. 2007 Dec 10;175(1-3):1-7. Epub 2007 Aug 22.

密度	1.14±0.1 g/cm3
沸点	359.6±25.0 °C
分子式	C₁₂H₂₃N₃S
分子量	241.39600
精确质量	241.16100
PSA	87.04000
LogP	4.05770
储存条件	2-8°C

危害码 (欧洲)	Xi
危险品运输编码	NONH for all modes of transport
海关编码	2930909090

海关编码	2930909090
中文概述	2930909090. 其他有机硫化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
申报要素	品名, 成分含量, 用途
Summary	2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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2-Hexyl-1-cyclopentanone thiosemicarbazone 33M20 BLT1 Block lipid transport-1 MIT 9952-53

BLT1

Block lipid transport-1

2-hexyl-1-cyclopentanone thiosemicarbazone