T 0156 hydrochloride

• 常用名: T 0156 hydrochloride
• 英文名: T 0156 hydrochloride
• CAS号: 324572-93-2
• 分子量: 620.05
• 密度: N/A
• 沸点: N/A
• 分子式: C₃₁H₃₀ClN₅O₇
• 熔点: N/A
• 闪点: N/A

T 0156 hydrochloride用途

T-0156是一种有效的选择性磷酸二酯酶5型(PDE5)抑制剂。T-0156以竞争方式(IC50=0.23 nM)特异性抑制PDE5水解环鸟苷单磷酸(cGMP)。T-0156抑制PDE6(IC50=56 nM),对PDE1、PDE2、PDE3和PDE4的效力较低(IC50>10μM)。T-0156增强一氧化氮(NO)/cGMP途径【1】。

T 0156 hydrochloride名称

• 英文名: T 0156 hydrochloride

T 0156 hydrochloride生物活性

• 描述: T-0156是一种有效的选择性磷酸二酯酶5型(PDE5)抑制剂。T-0156以竞争方式(IC50=0.23 nM)特异性抑制PDE5水解环鸟苷单磷酸(cGMP)。T-0156抑制PDE6(IC50=56 nM),对PDE1、PDE2、PDE3和PDE4的效力较低(IC50>10μM)。T-0156增强一氧化氮(NO)/cGMP途径【1】。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> 磷酸二酯酶(PDE)
  研究领域 >> 神经疾病
• 靶点实验:

  PDE5:0.23 nM (IC50)

  PDE1:>100 μM (IC50)

  PDE2:>100 μM (IC50)

  PDE3:>100 μM (IC50)

  PDE4:63 μM (IC50)

  PDE6:56 nM (IC50)

• 体外研究: 10和100 nM处的T-0156增加cGMP水平,导致离体兔海绵体组织松弛【1】。
• 参考文献:

  [1]. Hideki Mochida, et al. Enzymological and pharmacological profile of T-0156, a potent and selective phosphodiesterase type 5 inhibitor. Eur J Pharmacol. 2002 Dec 5;456(1-3):91-8.

T 0156 hydrochloride物理化学性质

• 分子式: C₃₁H₃₀ClN₅O₇
• 分子量: 620.05
• 精确质量: 619.183350
• InChIKey: RBJCBXAXUHCWBR-UHFFFAOYSA-N
• SMILES: COC(=O)c1c(-c2cc(OC)c(OC)c(OC)c2)c2ccnc(OCc3ncccn3)c2c(=O)n1Cc1ccnc(C)c1.Cl

T 0156 hydrochloride靶点实验

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T 0156 hydrochloride英文别名

• Methyl 2-[(2-methylpyridin-4-yl)methyl]-1-oxo-8-(pyrimidin-2-ylmethoxy)-4-(3,4,5-trimethoxyphenyl)-1,2-dihydro-2,7-naphthyridine-3-carboxylate hydrochloride (1:1)
• 2,7-Naphthyridine-3-carboxylic acid, 1,2-dihydro-2-[(2-methyl-4-pyridinyl)methyl]-1-oxo-8-(2-pyrimidinylmethoxy)-4-(3,4,5-trimethoxyphenyl)-, methyl ester, hydrochloride (1:1)
• MFCD03453030
• Methyl 2-[(2-methyl-4-pyridinyl)methyl]-1-oxo-8-(2-pyrimidinylmethoxy)-4-(3,4,5-trimethoxyphenyl)-1,2-dihydro-2,7-naphthyridine-3-carboxylate hydrochloride (1:1)