(1R,4aS,10aR)-7-异丙基-1,4a-二甲基-6-磺基-1,2,3,4,4a,9,10,10a-八氢菲-1-羧酸

• 常用名: (1R,4aS,10aR)-7-异丙基-1,4a-二甲基-6-磺基-1,2,3,4,4a,9,10,10a-八氢菲-1-羧酸
• 英文名: Ecabet
• CAS号: 33159-27-2
• 分子量: 380.49800
• 密度: 1.241 g/cm3
• 沸点: N/A
• 分子式: C₂₀H₂₈O₅S
• 熔点: N/A
• 闪点: N/A

用途

Ecabet钠(TA-2711)目前通过抑制活性氧的产生和促进幽门螺杆菌的根除被应用于一些临床胃肠道疾病[1]。Ecabet钠减少细胞凋亡[2]

名称

• 中文名: 依卡倍特
• 英文名: (1R,4aS,10aR)-1,4a-dimethyl-7-propan-2-yl-6-sulfo-2,3,4,9,10,10a-hexahydrophenanthrene-1-carboxylic acid

生物活性

• 描述: Ecabet钠(TA-2711)目前通过抑制活性氧的产生和促进幽门螺杆菌的根除被应用于一些临床胃肠道疾病[1]。Ecabet钠减少细胞凋亡[2]
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 细菌
• 参考文献:

  [1]. Wang Y, et al. Efficacy and safety of ecabet sodium as an adjuvant therapy for Helicobacter pylori eradication: a systematic review and meta-analysis. Helicobacter. 2014 Oct;19(5):372-81.

  [2]. Rah YC, et al. Ecabet sodium alleviates neomycin-induced hair cell damage. Free Radic Biol Med. 2015 Dec;89:1176-83.

物理化学性质

• 密度: 1.241 g/cm3
• 分子式: C₂₀H₂₈O₅S
• 分子量: 380.49800
• 精确质量: 380.16600
• PSA: 100.05000
• LogP: 5.23240
• InChIKey: IWCWQNVIUXZOMJ-MISYRCLQSA-N
• SMILES: CC(C)c1cc2c(cc1S(=O)(=O)O)C1(C)CCCC(C)(C(=O)O)C1CC2
• 折射率: 1.562
• 储存条件: 室温，干燥，密封

安全信息

• 危害码 (欧洲): Xi

靶点实验

查看更多实验

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实验名称：Cytotoxicity counterscreen for inhibitors of SARS-CoV-2 cell entry 来源：NCGC 靶标：N/A External Id：TRND-SARS-CoV-2-cytotox-48hr

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英文别名

• Ecabet
• sulfodehydroabietic acid
• Ecabetum
• Gastrom
• 12-sulfodehydroabietic acid