芬诺宁

• 常用名: 芬诺宁
• 英文名: Fenoverine
• CAS号: 37561-27-6
• 分子量: 459.56
• 密度: 1.343g/cm3
• 沸点: 671.8ºC at 760mmHg
• 分子式: C₂₆H₂₅N₃O₃S
• 熔点: N/A
• 闪点: 360.1ºC

芬诺宁用途

芬诺威是一种抗痉挛药物,可抑制钙通道电流[1]。芬诺威诱导横纹肌溶解症[2]。

芬诺宁名称

• 中文名: 芬诺宁
• 英文名: 2-[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]-1-phenothiazin-10-ylethanone

芬诺宁生物活性

• 描述: 芬诺威是一种抗痉挛药物,可抑制钙通道电流[1]。芬诺威诱导横纹肌溶解症[2]。
• 相关类别:
  信号通路 >> 跨膜转运 >> 钙通道
  研究领域 >> 神经疾病
• 参考文献:

  [1]. J Mironneau, et al. Fenoverine inhibition of calcium channel currents in single smooth muscle cells from rat portal vein and myometrium. Br J Pharmacol. 1991 Sep;104(1):65-70.

  [2]. Chung-Wen Chen, et al. Rhabdomyolysis induced by fenoverine: a case report and literature review. Acta Neurol Taiwan. 2005 Sep;14(3):143-6.

芬诺宁物理化学性质

• 密度: 1.343g/cm3
• 沸点: 671.8ºC at 760mmHg
• 分子式: C₂₆H₂₅N₃O₃S
• 分子量: 459.56
• 闪点: 360.1ºC
• 精确质量: 459.16200
• PSA: 70.55000
• LogP: 4.30320
• InChIKey: UBAJTZKNDCEGKL-UHFFFAOYSA-N
• SMILES: O=C(CN1CCN(Cc2ccc3c(c2)OCO3)CC1)N1c2ccccc2Sc2ccccc21
• 折射率: 1.678

芬诺宁毒性和生态

芬诺宁靶点实验

查看更多实验

实验名称：Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression 来源：NCGC External Id：SNCA-p-activity-luciferase

实验名称：Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: lu... 来源：824 External Id：CYP273

实验名称：Dicer-mediated maturation of pre-microRNA 来源：Center for Chemical Genomics, University of Michigan 靶标：N/A External Id：TargetID_659_CEMA

实验名称：p53 small molecule agonists, cell-based qHTS assay: qHTS cell viability counter scree... 来源：824 靶标：N/A External Id：P53600

实验名称：p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: qHTS ce... 来源：824 靶标：N/A External Id：P53MS958

实验名称：p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: Summary 来源：824 External Id：P53MS482

实验名称：p53 small molecule agonists, cell-based qHTS assay 来源：824 External Id：P53344

实验名称：p53 small molecule agonists, cell-based qHTS assay with human liver microsomes 来源：824 靶标：tumor suppressor p53 [Homo sapiens] External Id：P53MS233

实验名称：p53 small molecule agonists, cell-based qHTS assay with human liver microsomes: qHTS ... 来源：824 靶标：N/A External Id：P53MS837

实验名称：p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes 来源：824 靶标：tumor suppressor p53 [Homo sapiens] External Id：P53MS898

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芬诺宁英文别名

• Fenoverine
• Spasmopriv
• EINECS 253-552-1