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芬诺宁

芬诺宁用途

芬诺威是一种抗痉挛药物,可抑制钙通道电流[1]。芬诺威诱导横纹肌溶解症[2]。

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芬诺宁名称

[ CAS 号 ]:
37561-27-6

[ 中文名 ]:
芬诺宁

[ 英文名 ]:
Fenoverine

[英文别名 ]:

Fenoverine
Spasmopriv
EINECS 253-552-1

芬诺宁生物活性

[ 描述 ]:

芬诺威是一种抗痉挛药物,可抑制钙通道电流[1]。芬诺威诱导横纹肌溶解症[2]。

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> 钙通道

研究领域 >> 神经疾病

[参考文献]

[1]. J Mironneau, et al. Fenoverine inhibition of calcium channel currents in single smooth muscle cells from rat portal vein and myometrium. Br J Pharmacol. 1991 Sep;104(1):65-70.

[2]. Chung-Wen Chen, et al. Rhabdomyolysis induced by fenoverine: a case report and literature review. Acta Neurol Taiwan. 2005 Sep;14(3):143-6.

芬诺宁物理化学性质

[ 密度 ]:
1.343g/cm3

[ 沸点 ]:
671.8ºC at 760mmHg

[ 分子式 ]:
C₂₆H₂₅N₃O₃S

[ 分子量 ]:
459.56

[ 闪点 ]:
360.1ºC

[ 精确质量 ]:
459.16200

[ PSA ]:
70.55000

[ LogP ]:
4.30320

[ 折射率 ]:
1.678

芬诺宁毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SN5445000

CHEMICAL NAME :: 10H-Phenothiazine, 10-((4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl)ace tyl)-

CAS REGISTRY NUMBER :: 37561-27-6

LAST UPDATED :: 199312

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C26-H25-N3-O3-S

MOLECULAR WEIGHT :: 459.60

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2874 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DECRDP Drugs under Experimental and Clinical Research. (Bioscience Ediprint, Blvd. James-Fazy 13, 1201 Geneva 1, Switzerland) V.1- 1977- Volume(issue)/page/year: 15,37,1989