N-(4-叔丁苯基)-4-(3-氯吡啶-2-基)哌嗪-1-甲酰胺

更新时间：2026-06-29 17:54:46

N-(4-叔丁苯基)-4-(3-氯吡啶-2-基)哌嗪-1-甲酰胺结构式	常用名	N-(4-叔丁苯基)-4-(3-氯吡啶-2-基)哌嗪-1-甲酰胺	英文名	BCTC
	CAS号	393514-24-4	分子量	372.892
	密度	1.2±0.1 g/cm3	沸点	561.6±50.0 °C at 760 mmHg
	分子式	C₂₀H₂₅ClN₄O	熔点	N/A
	MSDS	中文版美版	闪点	293.4±30.1 °C
	符号	GHS07	信号词	Warning

用途

BCTC作用于前列腺癌 (PCa) DU145细胞,有效且特异性抑制瞬时受体阳离子通道M成员8(TRPM8)。

本表展示该化学物质的中文名称、英文系统名、各类中文与英文别名信息。

中文名	N-(4-叔丁苯基)-4-(3-氯吡啶-2-基)哌嗪-1-甲酰胺
英文名	N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)piperazine-1-carboxamide
英文别名	更多

本表记录该化合物相关生物活性、作用靶点、活性说明与生物实验相关数据。

描述	BCTC作用于前列腺癌 (PCa) DU145细胞,有效且特异性抑制瞬时受体阳离子通道M成员8(TRPM8)。
相关类别	信号通路 >> 跨膜转运 >> TRP频道研究领域 >> 癌症
参考文献	[1]. Liu T, et al. Anti-tumor activity of the TRPM8 inhibitor BCTC in prostate cancer DU145 cells. Oncol Lett. 2016 Jan;11(1):182-188. [2]. Pomonis JD, et al. N-(4-Tertiarybutylphenyl)-4-(3-cholorphyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: II. in vivo characterization in rat models of inflamm [3]. Valenzano KJ, et al. N-(4-tertiarybutylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: I. in vitro characterization and pharmacokinetic pro

描述

BCTC作用于前列腺癌 (PCa) DU145细胞,有效且特异性抑制瞬时受体阳离子通道M成员8(TRPM8)。

相关类别

信号通路 >> 跨膜转运 >> TRP频道

研究领域 >> 癌症

参考文献

[1]. Liu T, et al. Anti-tumor activity of the TRPM8 inhibitor BCTC in prostate cancer DU145 cells. Oncol Lett. 2016 Jan;11(1):182-188.

[2]. Pomonis JD, et al. N-(4-Tertiarybutylphenyl)-4-(3-cholorphyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: II. in vivo characterization in rat models of inflamm

[3]. Valenzano KJ, et al. N-(4-tertiarybutylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: I. in vitro characterization and pharmacokinetic pro

本表包含该物质理化参数，如熔点、沸点、密度、溶解度、旋光性等理化指标，无数据项标记为N/A。

密度	1.2±0.1 g/cm3
沸点	561.6±50.0 °C at 760 mmHg
分子式	C₂₀H₂₅ClN₄O
分子量	372.892
闪点	293.4±30.1 °C
精确质量	372.171692
PSA	48.47000
LogP	4.08
InChIKey	ROGUAPYLUCHQGK-UHFFFAOYSA-N
SMILES	CC(C)(C)c1ccc(NC(=O)N2CCN(c3ncccc3Cl)CC2)cc1
蒸汽压	0.0±1.5 mmHg at 25°C
折射率	1.610
储存条件	2-8℃

本表为化学品安全说明书MSDS数据，包含危险标识、成分、急救、消防、泄漏处置、操作储存等安全信息。

MSDS英文版

本表记录该化合物安全警示、防护措施、禁配物、处置方式等安全相关参考信息。

符号	GHS07
信号词	Warning
危害声明	H302
危险品运输编码	NONH for all modes of transport

本表为该化合物相关公开文献，包含文献标题、期刊、发表信息等参考资料。

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J. Neurosci. 35(2) , 571-82, (2015)

The spatial and temporal distribution of receptors constitutes an important mechanism for controlling the magnitude of cellular responses. Several members of the transient receptor potential (TRP) ion...

Temperature oscillations drive cycles in the activity of MMP-2,9 secreted by a human trabecular meshwork cell line.

Invest. Ophthalmol. Vis. Sci. 56(2) , 1396-405, (2015)

Aqueous humor inflow falls 50% during sleeping hours without proportional fall in IOP, partly reflecting reduced outflow facility. The mechanisms underlying outflow facility cycling are unknown. One o...

本表记录该化合物靶点、体外体内实验、生物测定实验相关实验数据。

实验名称：Antagonist activity at human TRPV1 expressed in HEK cells assessed as inhibition of 1...
来源：ChEMBL
靶标：Transient receptor potential cation channel subfamily V member 1
External Id：CHEMBL4775810

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (...
来源：NCGC
External Id：IP6K1-p1

实验名称：Inhibition of 5-LOX (unknown origin)
来源：ChEMBL
靶标：Polyunsaturated fatty acid 5-lipoxygenase
External Id：CHEMBL5239814

实验名称：Inhibition of human vanilloid receptor 1 in HEK293 cells in pH 5.5-induced FLIPR assa...
来源：ChEMBL
靶标：Transient receptor potential cation channel subfamily V member 1
External Id：CHEMBL827822

实验名称：Inhibition of TRPV1 (unknown origin)
来源：ChEMBL
靶标：Transient receptor potential cation channel subfamily V member 1
External Id：CHEMBL5239815

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu...
来源：NCGC
External Id：CYP3A4437

实验名称：Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu...
来源：NCGC
External Id：CYP2D6395

实验名称：Inhibition of COX1 (unknown origin)
来源：ChEMBL
靶标：Prostaglandin G/H synthase 1
External Id：CHEMBL5239812

实验名称：Hypoglycemic activity against ICR mouse assessed as decrease in blood glucose at 20 m...
来源：ChEMBL
靶标：Mus musculus
External Id：CHEMBL5552041

实验名称：Inhibition of human TRPV1 expressed in HEK293 cells assessed as reduction in capsaici...
来源：ChEMBL
靶标：Transient receptor potential cation channel subfamily V member 1
External Id：CHEMBL4235541

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本表罗列该化合物全部英文别名、系统命名、CAS别名等英文名称集合。

N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)piperazine-1-carboxamide

4-(3-Chloro-2-pyridinyl)-N-[4-(2-methyl-2-propanyl)phenyl]-1-piperazinecarboxamide

bctc

本部分为该化合物相关常见问答，包含基础参数、性状、储存条件等高频咨询问题与对应答案。

Q: N-(4-叔丁苯基)-4-(3-氯吡啶-2-基)哌嗪-1-甲酰胺的英文名称是什么？

A: N-(4-叔丁苯基)-4-(3-氯吡啶-2-基)哌嗪-1-甲酰胺英文名称为N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)piperazine-1-carboxamide。

Q: N-(4-叔丁苯基)-4-(3-氯吡啶-2-基)哌嗪-1-甲酰胺的LogP（油水分配系数）是多少？

A: N-(4-叔丁苯基)-4-(3-氯吡啶-2-基)哌嗪-1-甲酰胺LogP（油水分配系数）为4.08。

Q: N-(4-叔丁苯基)-4-(3-氯吡啶-2-基)哌嗪-1-甲酰胺的极性表面积PSA是多少？

A: N-(4-叔丁苯基)-4-(3-氯吡啶-2-基)哌嗪-1-甲酰胺极性表面积PSA为48.47000。