N-(4-叔丁苯基)-4-(3-氯吡啶-2-基)哌嗪-1-甲酰胺

更新时间：2025-08-26 22:19:10

N-(4-叔丁苯基)-4-(3-氯吡啶-2-基)哌嗪-1-甲酰胺结构式	常用名	N-(4-叔丁苯基)-4-(3-氯吡啶-2-基)哌嗪-1-甲酰胺	英文名	BCTC
	CAS号	393514-24-4	分子量	372.892
	密度	1.2±0.1 g/cm3	沸点	561.6±50.0 °C at 760 mmHg
	分子式	C₂₀H₂₅ClN₄O	熔点	N/A
	MSDS	中文版美版	闪点	293.4±30.1 °C
	符号	GHS07	信号词	Warning

用途

BCTC作用于前列腺癌 (PCa) DU145细胞,有效且特异性抑制瞬时受体阳离子通道M成员8(TRPM8)。

中文名	N-(4-叔丁苯基)-4-(3-氯吡啶-2-基)哌嗪-1-甲酰胺
英文名	N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)piperazine-1-carboxamide
英文别名	更多

描述	BCTC作用于前列腺癌 (PCa) DU145细胞,有效且特异性抑制瞬时受体阳离子通道M成员8(TRPM8)。
相关类别	信号通路 >> 跨膜转运 >> TRP频道研究领域 >> 癌症
参考文献	[1]. Liu T, et al. Anti-tumor activity of the TRPM8 inhibitor BCTC in prostate cancer DU145 cells. Oncol Lett. 2016 Jan;11(1):182-188. [2]. Pomonis JD, et al. N-(4-Tertiarybutylphenyl)-4-(3-cholorphyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: II. in vivo characterization in rat models of inflamm [3]. Valenzano KJ, et al. N-(4-tertiarybutylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: I. in vitro characterization and pharmacokinetic pro

描述

BCTC作用于前列腺癌 (PCa) DU145细胞,有效且特异性抑制瞬时受体阳离子通道M成员8(TRPM8)。

相关类别

信号通路 >> 跨膜转运 >> TRP频道

研究领域 >> 癌症

参考文献

[1]. Liu T, et al. Anti-tumor activity of the TRPM8 inhibitor BCTC in prostate cancer DU145 cells. Oncol Lett. 2016 Jan;11(1):182-188.

[2]. Pomonis JD, et al. N-(4-Tertiarybutylphenyl)-4-(3-cholorphyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: II. in vivo characterization in rat models of inflamm

[3]. Valenzano KJ, et al. N-(4-tertiarybutylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: I. in vitro characterization and pharmacokinetic pro

密度	1.2±0.1 g/cm3
沸点	561.6±50.0 °C at 760 mmHg
分子式	C₂₀H₂₅ClN₄O
分子量	372.892
闪点	293.4±30.1 °C
精确质量	372.171692
PSA	48.47000
LogP	4.08
蒸汽压	0.0±1.5 mmHg at 25°C
折射率	1.610
储存条件	2-8℃

MSDS英文版

符号	GHS07
信号词	Warning
危害声明	H302
危险品运输编码	NONH for all modes of transport

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N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)piperazine-1-carboxamide

1-Piperazinecarboxamide, 4-(3-chloro-2-pyridinyl)-N-[4-(1,1-dimethylethyl)phenyl]-

4-(3-Chloro-2-pyridinyl)-N-[4-(2-methyl-2-propanyl)phenyl]-1-piperazinecarboxamide

bctc