N-(4-叔丁苯基)-4-(3-氯吡啶-2-基)哌嗪-1-甲酰胺

• 常用名: N-(4-叔丁苯基)-4-(3-氯吡啶-2-基)哌嗪-1-甲酰胺
• 英文名: BCTC
• CAS号: 393514-24-4
• 分子量: 372.892
• 密度: 1.2±0.1 g/cm3
• 沸点: 561.6±50.0 °C at 760 mmHg
• 分子式: C₂₀H₂₅ClN₄O
• 熔点: N/A
• 闪点: 293.4±30.1 °C
• 符号: GHS07
• 信号词: Warning

用途

BCTC作用于前列腺癌 (PCa) DU145细胞，有效且特异性抑制瞬时受体阳离子通道M成员8(TRPM8)。

名称

• 中文名: N-(4-叔丁苯基)-4-(3-氯吡啶-2-基)哌嗪-1-甲酰胺
• 英文名: N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)piperazine-1-carboxamide

生物活性

• 描述: BCTC作用于前列腺癌 (PCa) DU145细胞,有效且特异性抑制瞬时受体阳离子通道M成员8(TRPM8)。
• 相关类别:
  信号通路 >> 跨膜转运 >> TRP频道
  研究领域 >> 癌症
• 参考文献:

  [1]. Liu T, et al. Anti-tumor activity of the TRPM8 inhibitor BCTC in prostate cancer DU145 cells. Oncol Lett. 2016 Jan;11(1):182-188.

  [2]. Pomonis JD, et al. N-(4-Tertiarybutylphenyl)-4-(3-cholorphyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: II. in vivo characterization in rat models of inflamm

  [3]. Valenzano KJ, et al. N-(4-tertiarybutylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: I. in vitro characterization and pharmacokinetic pro

物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 561.6±50.0 °C at 760 mmHg
• 分子式: C₂₀H₂₅ClN₄O
• 分子量: 372.892
• 闪点: 293.4±30.1 °C
• 精确质量: 372.171692
• PSA: 48.47000
• LogP: 4.08
• InChIKey: ROGUAPYLUCHQGK-UHFFFAOYSA-N
• SMILES: CC(C)(C)c1ccc(NC(=O)N2CCN(c3ncccc3Cl)CC2)cc1
• 蒸汽压: 0.0±1.5 mmHg at 25°C
• 折射率: 1.610
• 储存条件: 2-8℃

MSDS

MSDS英文版

安全信息

• 符号: GHS07
• 信号词: Warning
• 危害声明: H302
• 危险品运输编码: NONH for all modes of transport

靶点实验

查看更多实验

实验名称：Antagonist activity at human TRPV1 expressed in HEK cells assessed as inhibition of 1... 来源：ChEMBL 靶标：Transient receptor potential cation channel subfamily V member 1 External Id：CHEMBL4775810

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Inhibition of 5-LOX (unknown origin) 来源：ChEMBL 靶标：Polyunsaturated fatty acid 5-lipoxygenase External Id：CHEMBL5239814

实验名称：Inhibition of human vanilloid receptor 1 in HEK293 cells in pH 5.5-induced FLIPR assa... 来源：ChEMBL 靶标：Transient receptor potential cation channel subfamily V member 1 External Id：CHEMBL827822

实验名称：Inhibition of TRPV1 (unknown origin) 来源：ChEMBL 靶标：Transient receptor potential cation channel subfamily V member 1 External Id：CHEMBL5239815

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

实验名称：Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu... 来源：NCGC External Id：CYP2D6395

实验名称：Inhibition of COX1 (unknown origin) 来源：ChEMBL 靶标：Prostaglandin G/H synthase 1 External Id：CHEMBL5239812

实验名称：Hypoglycemic activity against ICR mouse assessed as decrease in blood glucose at 20 m... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL5552041

实验名称：Inhibition of human TRPV1 expressed in HEK293 cells assessed as reduction in capsaici... 来源：ChEMBL 靶标：Transient receptor potential cation channel subfamily V member 1 External Id：CHEMBL4235541

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英文别名

• N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)piperazine-1-carboxamide
• 4-(3-Chloro-2-pyridinyl)-N-[4-(2-methyl-2-propanyl)phenyl]-1-piperazinecarboxamide
• bctc