马来酸阿扎他啶

• 常用名: 马来酸阿扎他啶
• 英文名: Azatadine dimaleate
• CAS号: 3978-86-7
• 分子量: 522.546
• 密度: N/A
• 沸点: 450.1ºC at 760 mmHg
• 分子式: C₂₈H₃₀N₂O₈
• 熔点: 152-154°
• 闪点: 226ºC
• 符号: GHS07
• 信号词: Warning

马来酸阿扎他啶用途

Azatadine马来酸氢盐是组胺受体和胆碱受体抑制剂,IC50分别为6.5 nM和10 nM。

马来酸阿扎他啶名称

• 中文名: 马来酸阿扎他啶
• 英文名: azatadine maleate
• 中文别名: 阿折地平二马来酸盐

马来酸阿扎他啶生物活性

• 描述: Azatadine马来酸氢盐是组胺受体和胆碱受体抑制剂,IC50分别为6.5 nM和10 nM。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 组胺受体
  信号通路 >> 免疫及炎症 >> 组胺受体
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Wilson JD, et al. Azatadine maleate (Zadine): evaluation in the management of allergic rhinitis. N Z Med J. 1981 Aug 12;94(689):79-81.

  [2]. Tozzi S, et al. The pharmacology of azatadine, a potential antiallergy drug. Agents Actions. 1974 Oct;4(4):264-70.

马来酸阿扎他啶物理化学性质

• 沸点: 450.1ºC at 760 mmHg
• 熔点: 152-154°
• 分子式: C₂₈H₃₀N₂O₈
• 分子量: 522.546
• 闪点: 226ºC
• 精确质量: 522.200195
• PSA: 165.33000
• LogP: 3.06920
• InChIKey: SGHXFFAHXTZRQM-SPIKMXEPSA-N
• SMILES: CN1CCC(=C2c3ccccc3CCc3cccnc32)CC1.O=C(O)C=CC(=O)O.O=C(O)C=CC(=O)O
• 储存条件: 室温，干燥

马来酸阿扎他啶毒性和生态

马来酸阿扎他啶安全信息

• 符号: GHS07
• 信号词: Warning
• 危害声明: H302-H336
• 警示性声明: P301 + P312 + P330
• 危险品运输编码: NONH for all modes of transport

马来酸阿扎他啶靶点实验

查看更多实验

实验名称：AlphaScreen-based biochemical high throughput primary assay to identify inhibitors of... 来源：The Scripps Research Institute Molecular Screening Center 靶标：N/A External Id：ULK1_INH_LUMI_1536_1X%INH PRUN

实验名称：Identifying Sarm1 Tir Hydrolase inhibitors through NAD-Glo assay 来源：24386 靶标：N/A External Id：Sarm1 Tir NADase inhibitors screen

实验名称：Dicer-mediated maturation of pre-microRNA 来源：Center for Chemical Genomics, University of Michigan 靶标：N/A External Id：TargetID_659_CEMA

实验名称：Drug Induced Liver Injury Prediction System (DILIps) validation dataset; compound DIL... 来源：ChEMBL 靶标：Hepatotoxicity External Id：CHEMBL1909323

实验名称：Literature-mined public compounds from Greene et al multi-species hepatotoxicity mode... 来源：ChEMBL 靶标：Hepatotoxicity External Id：CHEMBL1697722

实验名称：Human drug-induced liver injury (DILI) modelling dataset from Ekins et al 来源：ChEMBL 靶标：Hepatotoxicity External Id：CHEMBL1697730

实验名称：MELAS cybrid survival enhancement under low glucose conditions 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：N/A External Id：HMS1419

实验名称：Inhibition of cell viability relative to arbidol control (inhibition index > 1 indica... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4303819

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马来酸阿扎他啶英文别名

• 11-(1-methyl-piperidin-4-ylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine
• 11-(1-methylpiperidin-4-ylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine (2Z)-but-2-enedioate (1:2)
• Azatadinum [INN-Latin]
• Azatadina [INN-Spanish]
• 11-(1-methylpiperidin-4-ylidene)-5,6-dihydrobenzo[1,2]cyclohepta[3,4-b]pyridine
• Azatadina
• Optimine
• Idulian
• Azatadinum
• Azatidine
• 5H-Benzo[5,6]cyclohepta[1,2-b]pyridine, 6,11-dihydro-11-(1-methyl-4-piperidinylidene)-, (2Z)-2-butenedioate (1:2)
• 11-(1-Methyl-4-piperidinylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine (2Z)-2-butenedioate (1:2)
• Azatadine [INN:BAN]
• 6,11-dihydro-11-(1-methyl-4-piperidinylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridine
• Azatadine dimaleate
• 6,11--dihydro-11-(N-methyl-4-piperidylidene)-5H-benzo-[5,6]-cyclohepta-[1,2-b]-pyridine
• Azatadine maleate
• (Z)-but-2-enedioic acid,11-(1-methylpiperidin-4-ylidene)-5,6-dihydrobenzo[1,2]cyclohepta[3,4-b]pyridine
• Zadine
• Azatadin maleate
• AZATADINE
• EINECS 223-615-8
• Azatadine (dimaleate)