ANO1-IN-1

• 常用名: ANO1-IN-1
• 英文名: ANO1-IN-1
• CAS号: 407587-01-3
• 分子量: 336.49
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₈H₂₈N₂O₂S
• 熔点: N/A
• 闪点: N/A

ANO1-IN-1用途

ANO1-IN-1(化合物9c)是一种选择性ANO1通道阻滞剂,对ANO1和ANO2的IC50分别为2.56μM和15.43μM。ANO1-IN-1强烈抑制胶质母细胞瘤细胞的增殖[1]。

ANO1-IN-1名称

• 英文名: ANO1-IN-1

ANO1-IN-1生物活性

• 描述: ANO1-IN-1(化合物9c)是一种选择性ANO1通道阻滞剂,对ANO1和ANO2的IC50分别为2.56μM和15.43μM。ANO1-IN-1强烈抑制胶质母细胞瘤细胞的增殖[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 跨膜转运 >> 氯离子通道
• 靶点实验:

  IC50: 2.56 μM (ANO1), 15.43 μM (ANO2)[1]

• 体外研究: ANO1-IN-1(化合物9c)(10μM)显著抑制U251细胞的迁移和侵袭[1]。ANO1-IN-1和TMZ联合应用在抑制GBM细胞增殖方面具有显著的协同效应[1]。
• 参考文献:

  [1]. Choi SH, et al. Anti-glioma effects of 2-aminothiophene-3-carboxamide derivatives, ANO1 channel blockers. Eur J Med Chem. 2020 Dec 15;208:112688.

ANO1-IN-1物理化学性质

• 分子式: C₁₈H₂₈N₂O₂S
• 分子量: 336.49
• InChIKey: QJDASIZKRQHFFS-UHFFFAOYSA-N
• SMILES: CC(C)(C)C(=O)Nc1sc2c(c1C(N)=O)CCC(C(C)(C)C)C2

ANO1-IN-1靶点实验

查看更多实验

实验名称：Induction of ANO1 degradation in human U251 cells at 10 uM incubated for 24 hrs by we... 来源：ChEMBL 靶标：Anoctamin-1 External Id：CHEMBL4710558

实验名称：Inhibition of GFP-fused mouse ANO1 channel expressed in HEK293A cells assessed as inh... 来源：ChEMBL 靶标：Anoctamin-1 External Id：CHEMBL4710559

实验名称：Inhibition of cell migration in human U251 cells at 5 uM incubated for 18 hrs by woun... 来源：ChEMBL 靶标：U-251 External Id：CHEMBL4710556

实验名称：Inhibition of cell migration in human U251 cells incubated for 18 hrs by wound healin... 来源：ChEMBL 靶标：U-251 External Id：CHEMBL4710557

实验名称：Inhibition of ANO1 in human U251 cells assessed as inhibition of channel current at 1... 来源：ChEMBL 靶标：Anoctamin-1 External Id：CHEMBL4710562

实验名称：Reversible inhibition of GFP-fused mouse ANO1 channel expressed in HEK293A cells asse... 来源：ChEMBL 靶标：Anoctamin-1 External Id：CHEMBL4710560

实验名称：Antiproliferative activity against human U87MG cells overexpressing ANO1 assessed as ... 来源：ChEMBL 靶标：U-87 MG External Id：CHEMBL4710550

实验名称：Induction of ANO1 degradation in human U251 cells at 10 uM preincubated with compound... 来源：ChEMBL 靶标：Anoctamin-1 External Id：CHEMBL4710548

实验名称：Antiproliferative activity against human U251 cells overexpressing ANO1 assessed as r... 来源：ChEMBL 靶标：U-251 External Id：CHEMBL4710549

实验名称：Inhibition of anchorage-independent colony formation in human U251 cells incubated fo... 来源：ChEMBL 靶标：U-251 External Id：CHEMBL4710555

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