戊诺酰胺

更新时间：2025-08-24 17:44:47

戊诺酰胺结构式	常用名	戊诺酰胺	英文名	Valnoctamide
	CAS号	4171-13-5	分子量	143.22700
	密度	0.883g/cm3	沸点	274.4ºC at 760mmHg
	分子式	C₈H₁₇NO	熔点	113.5-114ºC
	MSDS	中文版美版	闪点	119.8ºC
	符号	GHS07	信号词	Warning

戊诺酰胺用途

Valnoctamide (Valmethamide) 是一种 Valproate 的衍生物,可用于治疗对苯二氮卓类药物有抗药性的癫痫。Valnoctamide (Valmethamide) 直接作用于 GABAA 受体。

中文名	戊诺酰胺
英文名	2-ethyl-3-methyl-pentanamide Axiquel Nirvanil
英文别名	更多

描述	Valnoctamide (Valmethamide) 是一种 Valproate 的衍生物,可用于治疗对苯二氮卓类药物有抗药性的癫痫。Valnoctamide (Valmethamide) 直接作用于 GABAA 受体。
相关类别	信号通路 >> 跨膜转运 >> GABA受体研究领域 >> 神经疾病信号通路 >> 神经信号通路 >> GABA受体
靶点	GABAA receptor[1]
参考文献	[1]. Spampanato J, et al. Valnoctamide enhances phasic inhibition: a potential target mechanism for the treatment of benzodiazepine-refractory status epilepticus. Epilepsia. 2014 Sep;55(9):e94-8.

密度	0.883g/cm3
沸点	274.4ºC at 760mmHg
熔点	113.5-114ºC
分子式	C₈H₁₇NO
分子量	143.22700
闪点	119.8ºC
精确质量	143.13100
PSA	43.09000
LogP	2.24430
InChIKey	QRCJOCOSPZMDJY-UHFFFAOYSA-N
SMILES	CCC(C)C(CC)C(N)=O
折射率	1.438

戊诺酰胺毒性英文版

符号	GHS07
信号词	Warning
危害声明	H302
危险品运输编码	NONH for all modes of transport
RTECS号	YV5950000
海关编码	2924199090

2-ethyl-3-methy...

82024-15-5

戊诺酰胺

4171-13-5

文献：Kaufmann, Dan; Bialer, Meir; Shimshoni, Jakob Avi; Devor, Marshall; Yagen, Boris Journal of Medicinal Chemistry, 2009 , vol. 52, # 22 p. 7236 - 7248

仲丁巴比妥

125-40-6

戊诺酰胺

4171-13-5

文献：Freifelder,M. et al. Journal of Organic Chemistry, 1961 , vol. 26, p. 203 - 206

3-甲基戊酸

105-43-1

戊诺酰胺

4171-13-5

文献：Kaufmann, Dan; Yagen, Boris; Minert, Anne; Wlodarczyk, Bogdan; Finnell, Richard H.; Schurig, Volker; Devor, Marshall; Bialer, Meir Neuropharmacology, 2010 , vol. 58, # 8 p. 1228 - 1236

2-ethyl-3-methy...

22414-77-3

戊诺酰胺

4171-13-5

文献：Katznelson; Kondakowa Doklady Akademii Nauk SSSR, 1934 , p. II 24 Chem. Zentralbl., 1935 , vol. 106, # I p. 2521

Propanedioic ac...

4372-17-2

戊诺酰胺

4171-13-5

文献：Katznelson; Kondakowa Doklady Akademii Nauk SSSR, 1934 , p. II 24 Chem. Zentralbl., 1935 , vol. 106, # I p. 2521

戊诺酰胺上游产品 5
CAS号82024-15-5 2-ethyl-3-methy... CAS号125-40-6 仲丁巴比妥 CAS号105-43-1 3-甲基戊酸 CAS号22414-77-3 2-ethyl-3-methy...
CAS号4372-17-2 Propanedioic ac...
戊诺酰胺下游产品 0

海关编码	2924199090
中文概述	2924199090. 其他无环酰胺（包括无环氨基甲酸酯)(包括其衍生物及盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
申报要素	品名, 成分含量, 用途, 包装
Summary	2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Structure activity relationship of human microsomal epoxide hydrolase inhibition by amide and acid analogues of valproic acid.

Pharm. Res. 17(2) , 216-21, (2000)

The purpose of this study was to evaluate the in vitro inhibitory potency of various amide analogues and derivatives of valproic acid toward human microsomal epoxide hydrolase (mEH).mEH inhibition was...

A comparative electrographic analysis of the effect of sec-butyl-propylacetamide on pharmacoresistant status epilepticus.

Neuroscience 231 , 145-56, (2013)

Better treatment of status epilepticus (SE), which typically becomes refractory after about 30 min, will require new pharmacotherapies. The effect of sec-butyl-propylacetamide (SPD), an amide derivati...

Amidic modification of valproic acid reduces skeletal teratogenicity in mice.

Birth Defects Res. B Dev. Reprod. Toxicol. 71(1) , 47-53, (2004)

The antiepileptic drug valproic acid (VPA) is well known to cause neural tube and skeletal defects in both humans and animals. The amidic VPA analogues valpromide (VPD) and valnoctamide (VCD) have muc...

2-ethyl-3-methylpentanamide

Valnoctamide