PU24FCl

• 常用名: PU24FCl
• 英文名: PU24FCl
• CAS号: 422508-46-1
• 分子量: 433.86400
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₀H₂₁ClFN₅O₃
• 熔点: N/A
• 闪点: N/A

PU24FCl用途

PU24FCl 是一种特异性的 Hsp90 抑制剂。PU24FCl 具有广泛的抗癌活性。PU24FCl 在肿瘤中积聚,同时从正常组织中迅速清除。

PU24FCl名称

• 英文名: 8-(2-Chloro-3,4,5-trimethoxybenzyl)-2-fluoro-9-(4-pentyn-1-yl)-9H -purin-6-amine

PU24FCl生物活性

• 描述: PU24FCl 是一种特异性的 Hsp90 抑制剂。PU24FCl 具有广泛的抗癌活性。PU24FCl 在肿瘤中积聚,同时从正常组织中迅速清除。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 代谢酶/蛋白酶 >> HSP
  信号通路 >> 细胞周期/DNA损伤 >> HSP
• 靶点实验:

  HSP90

• 参考文献:

  [1]. Vilenchik M, et, al. Targeting wide-range oncogenic transformation via PU24FCl, a specific inhibitor of tumor Hsp90. Chem Biol. 2004 Jun;11(6):787-97.

PU24FCl物理化学性质

• 分子式: C₂₀H₂₁ClFN₅O₃
• 分子量: 433.86400
• 精确质量: 433.13200
• PSA: 97.31000
• LogP: 3.81220
• InChIKey: KCIOVTSUEXGUFJ-UHFFFAOYSA-N
• SMILES: C#CCCCn1c(Cc2cc(OC)c(OC)c(OC)c2Cl)nc2c(N)nc(F)nc21

PU24FCl靶点实验

查看更多实验

实验名称：Inhibition of Hsp70 in human SKBR3 cells assessed as RAF1 protein degradation by West... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3128988

实验名称：Inhibition of Hsp70 in human SKBR3 cells assessed as HER2 protein degradation by West... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3128989

实验名称：Her-2 Degradation Assay from Article 10.1021/jm0503087: "Orally active purine-based i... 来源：BindingDB 靶标：N/A External Id：BindingDB_2455_1

实验名称：Effective concentration against heat shock protein HSP90-alpha in MDA-MB-468 cells 来源：ChEMBL 靶标：Heat shock protein HSP 90-alpha External Id：CHEMBL829731

实验名称：Experimentally measured binding affinity data (IC50) for protein-ligand complexes der... 来源：Shanghai Institute of Organic Chemistry 靶标：N/A External Id：PDBbind-IC50 for protein-ligand complexes

实验名称：Her-2 Degradation Assay from Article 10.1021/jm050752+: "Rationally designed high-aff... 来源：BindingDB 靶标：N/A External Id：BindingDB_2458_1

实验名称：Inhibitory concentration against SKBr3 cell line 来源：ChEMBL 靶标：SK-BR-3 External Id：CHEMBL834754

实验名称：Inhibition of human recombinant HSP90 in MCF7 cells assessed as Her2 degradation 来源：ChEMBL 靶标：Heat shock protein HSP 90-alpha External Id：CHEMBL904863

实验名称：Binding affinity to human recombinant HSP90 assessed as inhibition of biotinylated-ge... 来源：ChEMBL 靶标：Heat shock protein HSP 90-alpha External Id：CHEMBL904865

实验名称：Inhibition of Hsp90 protein as degradation of HER2 kinase in SKBr3 cells 来源：ChEMBL 靶标：Heat shock protein HSP 90-alpha External Id：CHEMBL830912

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