方式163909

• 常用名: 方式163909
• 英文名: WAY 163909
• CAS号: 428868-32-0
• 分子量: 214.306
• 密度: 1.2±0.1 g/cm3
• 沸点: 350.4±21.0 °C at 760 mmHg
• 分子式: C₁₄H₁₈N₂
• 熔点: N/A
• 闪点: 160.2±13.0 °C

方式163909用途

WAY 163909 是有效的且有选择性的 5-HT(2C) receptor 激动剂, Ki 值为 10.5±1.1 nM。

方式163909名称

• 中文名: (7Br,10ar)-2,3,4,7b,8,9,10,10a-八氢-1H-环戊并[b][1,4]二氮杂革并[6,7,1-hi]吲哚
• 英文名: way-163909

方式163909生物活性

• 描述: WAY 163909 是有效的且有选择性的 5-HT(2C) receptor 激动剂, Ki 值为 10.5±1.1 nM。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 5-HT受体
  信号通路 >> 神经信号通路 >> 5-HT受体
  研究领域 >> 癌症
• 靶点实验:

  5-HT2C Receptor:10.5±1.1 nM (Ki)

• 参考文献:

  [1]. Dunlop J1,WAY-163909 [(7bR, 10aR)-1,2,3,4,8,9,10,10a-octahydro-7bH-cyclopenta-[b][1,4]diazepino[6,7,1hi]indole], a novel 5-hydroxytryptamine 2C receptor-selective agonist with anorectic activity. J Pharmacol Exp Ther. 2005 May; 313(2):862-9. Epub 2005 Feb 10.

方式163909物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 350.4±21.0 °C at 760 mmHg
• 分子式: C₁₄H₁₈N₂
• 分子量: 214.306
• 闪点: 160.2±13.0 °C
• 精确质量: 214.147003
• PSA: 15.27000
• LogP: 2.11
• InChIKey: XOSKJKGKWRIMGV-DGCLKSJQSA-N
• SMILES: c1cc2c3c(c1)C1CCCC1N3CCNC2
• 蒸汽压: 0.0±0.8 mmHg at 25°C
• 折射率: 1.645

方式163909靶点实验

查看更多实验

实验名称：Intracellular Calcium Assay from US Patent US10544152: "5-HT2CR agonist analogs" 来源：BindingDB 靶标：N/A External Id：BindingDB_8913_1

实验名称：Selectivity index, ratio of Ki for binding affinity to 5HT2B (unknown origin) to Ki f... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4617408

实验名称：Neurobiological activity in Sprague-Dawley rat assessed as increase in number of rat ... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL4624934

实验名称：Neurobiological activity in Sprague-Dawley rat assessed as increase in number of rat ... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL4624936

实验名称：Neurobiological activity in Sprague-Dawley rat assessed as increase in number of rat ... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL4624935

实验名称：Selectivity index, ratio of Ki for binding affinity to 5HT2A (unknown origin) to Ki f... 来源：ChEMBL 靶标：Serotonin 2 receptors; 5-HT2a & 5-HT2c External Id：CHEMBL4617403

实验名称：Neurobiological activity in Sprague-Dawley rat assessed as increase in number of rat ... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL4624937

实验名称：Human 5-HT2C receptor (5-Hydroxytryptamine receptors) 来源：IUPHAR-DB 靶标：5-HT2C receptor (5-Hydroxytryptamine receptors) [Homo sapiens] External Id：8_Human

实验名称：Agonist activity at 5HT2C receptor (unknown origin) relative to control 来源：ChEMBL 靶标：5-hydroxytryptamine receptor 2C External Id：CHEMBL3419948

实验名称：Neurobiological activity in Sprague-Dawley rat assessed as increase in number of rat ... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL4624928

共13条，当前第1页，共2页

1

2

方式163909英文别名

• (7bR,10aR)-1,2,3,4,8,9,10,10a-Octahydro-7bH-cyclopenta[b][1,4]diazepino[6,7,1-hi]indole
• ps-kr-n0
• WAY 163909