4-(2-氯苯基)-2,6-二甲基-1,4-二氢吡啶-3,5-二羧酸二甲酯

• 常用名: 4-(2-氯苯基)-2,6-二甲基-1,4-二氢吡啶-3,5-二羧酸二甲酯
• 英文名: Amlodipine besilate impurity G
• CAS号: 43067-01-2
• 分子量: 335.782
• 密度: 1.2±0.1 g/cm3
• 沸点: 436.7±45.0 °C at 760 mmHg
• 分子式: C₁₇H₁₈ClNO₄
• 熔点: N/A
• 闪点: 217.9±28.7 °C
• 符号: GHS07
• 信号词: Warning

用途

Calcium Channel antagonist 1 是 Calcium Channel 的拮抗剂。Calcium Channel antagonist 1 在神经病学疾病的研究中具有潜在的应用价值。

名称

• 中文名: 苯磺酸氨氯地平杂质 G
• 英文名: Dimethyl 4-(2-Chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

生物活性

• 描述: Calcium Channel antagonist 1 是 Calcium Channel 的拮抗剂。Calcium Channel antagonist 1 在神经病学疾病的研究中具有潜在的应用价值。
• 相关类别:
  信号通路 >> 跨膜转运 >> 钙通道
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Ivanciuc O, et, al. Comparative receptor surface analysis (CoRSA) model for calcium channel antagonists. SAR QSAR Environ Res. 2001;12(1-2):93-111.

物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 436.7±45.0 °C at 760 mmHg
• 分子式: C₁₇H₁₈ClNO₄
• 分子量: 335.782
• 闪点: 217.9±28.7 °C
• 精确质量: 335.092438
• PSA: 64.63000
• LogP: 3.83
• InChIKey: REIGLQUFMMOAFU-UHFFFAOYSA-N
• SMILES: COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1c1ccccc1Cl
• 蒸汽压: 0.0±1.0 mmHg at 25°C
• 折射率: 1.546
• 储存条件: 2-8°C

安全信息

• 符号: GHS07
• 信号词: Warning
• 危害声明: H302-H315-H319-H335
• 警示性声明: P301 + P312 + P330-P305 + P351 + P338
• 危险品运输编码: NONH for all modes of transport
• 海关编码: 2933399090

海关

• 海关编码: 2933399090
• 中文概述: 2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
• 申报要素: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
• Summary: 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

靶点实验

查看更多实验

实验名称：Solvation energy 来源：ChEMBL 靶标：N/A External Id：CHEMBL849146

实验名称：Effective concentration required to produce mechanical response determined in muscle ... 来源：ChEMBL 靶标：Cavia porcellus External Id：CHEMBL858250

实验名称：Discovery of Small Molecules to Inhibit Human Cytomegalovirus Nuclear Egress 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：HCMV UL50 External Id：HMS1262

实验名称：Compound was tested for its antagonist activity against calcium channel 来源：ChEMBL 靶标：N/A External Id：CHEMBL684383

实验名称：Compound was tested for ability to relax potassium-contracted rabbit aorta smooth mus... 来源：ChEMBL 靶标：Oryctolagus cuniculus External Id：CHEMBL772349

实验名称：Cell-based high throughput primary assay to identify activators of GPR151 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=G-protein coupled receptor 151; AltName: Full=G-protein coupled receptor PGR7; AltName: Full=GPCR-2037; AltName: Full=Galanin receptor 4; AltName: Full=Galanin-receptor-like protein; Short=GalRL External Id：GPR151_PHUNTER_AG_LUMI_1536_1X%ACT

实验名称：Dissociation constant for inhibition of [3H]nitrendipine binding to guinea pig myocar... 来源：ChEMBL 靶标：Voltage-dependent L-type calcium channel subunit alpha-1C External Id：CHEMBL653730

实验名称：Bmax1 from dihydropyridine receptor binding assay in guinea pig myocardial membranes 来源：ChEMBL 靶标：Voltage-dependent L-type calcium channel subunit alpha-1C External Id：CHEMBL660545

实验名称：High-throughput screen for inhibitors of the GIV GBA-motif interaction with Galpha-i ... 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School External Id：HMS1303

实验名称：Bmax2 from dihydropyridine receptor binding assay in guinea pig myocardial membranes 来源：ChEMBL 靶标：Voltage-dependent L-type calcium channel subunit alpha-1C External Id：CHEMBL660547

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英文别名

• Dimethyl 4-(2-chlorophenyl)-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylate
• 3,5-Pyridinedicarboxylic acid, 4-(2-chlorophenyl)-1,4-dihydro-2,6-dimethyl-, dimethyl ester
• dimethyl 4-(2-chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
• Amlodipine Impurity 7