雌酮3-硫酸钠盐

• 常用名: 雌酮3-硫酸钠盐
• 英文名: Estrone sulfate sodium
• CAS号: 438-67-5
• 分子量: 372.41
• 密度: 1.349 g/cm3
• 沸点: N/A
• 分子式: C₁₈H₂₁NaO₅S
• 熔点: 258-260°C
• 闪点: N/A
• 符号: GHS07, GHS08
• 信号词: Danger

雌酮3-硫酸钠盐用途

雌酮硫酸盐是一种生物活性雌激素,是一种主要的循环血浆雌激素,通过类固醇硫酸酯酶(STS)转化为生物活性雌激素雌酮(E1)。硫酸锶可用于乳腺癌的研究[1][2]。

雌酮3-硫酸钠盐名称

• 中文名: 雌酮3-硫酸钠
• 英文名: estrone sodium sulfate
• 中文别名: 3-硫酸雌酮钠盐 | 雌酮硫酸钠 | 雌酮 3-硫酸酯钠盐

雌酮3-硫酸钠盐生物活性

• 描述: 雌酮硫酸盐是一种生物活性雌激素,是一种主要的循环血浆雌激素,通过类固醇硫酸酯酶(STS)转化为生物活性雌激素雌酮(E1)。硫酸锶可用于乳腺癌的研究[1][2]。
• 相关类别:
  信号通路 >> 其他 >> 雌激素受体/ERR
  研究领域 >> 癌症
• 靶点实验:

  Human Endogenous Metabolite

• 体外研究: 用SOAT稳定转染T47D细胞,并在生理相关浓度下增加硫酸雌酮和雌二醇浓度进行培养。1 nM雌二醇和EC50为2.2 nM的硫酸雌酮可显著增加细胞增殖[3]。
• 参考文献:

  [1]. Nakamura Y, et al. Steroid sulfatase and estrogen sulfotransferase in the atherosclerotic human aorta. Am J Pathol. 2003;163(4):1329-1339.

  [2]. Duncan L, et al. Inhibition of estrone sulfatase activity by estrone-3-methylthiophosphonate: a potential therapeutic agent in breast cancer. Cancer Res. 1993;53(2):298-303.

  [3]. Karakus E, et al. Estrone-3-Sulfate Stimulates the Proliferation of T47D Breast Cancer Cells Stably Transfected With the Sodium-Dependent Organic Anion Transporter SOAT (SLC10A6). Front Pharmacol. 2018;9:941. Published 2018 Aug 21.

雌酮3-硫酸钠盐物理化学性质

• 密度: 1.349 g/cm3
• 熔点: 258-260°C
• 分子式: C₁₈H₂₁NaO₅S
• 分子量: 372.41
• 精确质量: 372.100739
• PSA: 91.88000
• LogP: 4.03160
• InChIKey: VUCAHVBMSFIGAI-ZFINNJDLSA-M
• SMILES: CC12CCC3c4ccc(OS(=O)(=O)[O-])cc4CCC3C1CCC2=O.[Na+]
• 储存条件: -20°C

雌酮3-硫酸钠盐毒性和生态

雌酮3-硫酸钠盐安全信息

• 符号: GHS07, GHS08
• 信号词: Danger
• 危害声明: H315-H319-H335-H350
• 警示性声明: P201-P261-P305 + P351 + P338-P308 + P313
• 危害码 (欧洲): T: Toxic;
• 风险声明 (欧洲): R45-36/37/38
• 安全声明 (欧洲): S53-45-26
• 危险品运输编码: NONH for all modes of transport
• WGK德国: 3
• RTECS号: KG8775000

雌酮3-硫酸钠盐靶点实验

查看更多实验

实验名称：Inhibition of the Burkholderia mallei acyl-homoserine lactone synthase BmaI1 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：autoinducer synthetase family protein [Burkholderia mallei ATCC 23344] External Id：HMS1126

实验名称：Primary cell-based high-throughput screening assay for identification of compounds th... 来源：Johns Hopkins Ion Channel Center 靶标：regulator of G-protein signaling 4 isoform 2 [Homo sapiens] External Id：JHICC_RGS_Act_HTS

实验名称：Fluorescence-based counterscreen for orexin 1 receptor (OX1R) antagonists: cell-based... 来源：The Scripps Research Institute Molecular Screening Center 靶标：N/A External Id：CHOK1_ANT_FLUO8_1536_1X%INH CSRUN

实验名称：Absorbance-based primary biochemical high throughput screening assay to identify acti... 来源：The Scripps Research Institute Molecular Screening Center 靶标：caspase-3 preproprotein [Homo sapiens] External Id：PROCASPASE3_ACT_EPIABS_1536_1X%ACT PRUN

实验名称：Chemical Probes of Kaposi's Sarcoma Herpes Virus Latent Infection 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：ORF 73 [Human herpesvirus 8 type M] External Id：HMS791

实验名称：Antibacterial activity against Staphylococcus aureus MRSA ATCC 43300 (CO-ADD:GP_020);... 来源：ChEMBL 靶标：Staphylococcus aureus External Id：CHEMBL4296184

实验名称：Antibacterial activity against Klebsiella pneumoniae MDR ATCC 70063 (CO-ADD:GN_003); ... 来源：ChEMBL 靶标：Klebsiella pneumoniae External Id：CHEMBL4296186

实验名称：Primary cell-based high-throughput screening for identification of compounds that all... 来源：Johns Hopkins Ion Channel Center 靶标：MAS-related GPR member X1 [Homo sapiens] External Id：JHICC_MrgX1_AlloAgonist_Primary

实验名称：Antibacterial activity against Escherichia coli ATCC 25922 (CO-ADD:GN_001); MIC in CA... 来源：ChEMBL 靶标：Escherichia coli External Id：CHEMBL4296185

实验名称：A screen for compounds that inhibit the activity of LtaS in Staphylococcus aureus 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School External Id：HMS979

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雌酮3-硫酸钠盐英文别名

• Estra-1(10),2,4-trien-17-one, 3-(sulfooxy)-, sodium salt (1:1)
• Sodium 17-oxoestra-1(10),2,4-trien-3-yl sulfate
• Estrone 3-sulfate sodium salt
• Estrone sodium sulfate
• Estrone sulfate sodium
• Estrone-3-sulfate sodium salt
• estrone sodium sulphate
• Sodium estrone 3-sulfate