ML192

• 常用名: ML192
• 英文名: ML192
• CAS号: 460331-61-7
• 分子量: 382.479
• 密度: 1.3±0.1 g/cm3
• 沸点: N/A
• 分子式: C₂₀H₂₂N₄O₂S
• 熔点: N/A
• 闪点: N/A

ML192用途

ML192是GPR55的选择性配体拮抗剂。ML192抑制β-arrestin转运、ERK1/2磷酸化和PKCβII易位[1]。

ML192名称

• 英文名: ML-192

ML192生物活性

• 描述: ML192是GPR55的选择性配体拮抗剂。ML192抑制β-arrestin转运、ERK1/2磷酸化和PKCβII易位[1]。
• 相关类别:
  信号通路 >> 表观遗传学 >> PKC
  研究领域 >> 代谢疾病
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> GPR55
  信号通路 >> MAPK/ERK信号通路 >> ERK
  信号通路 >> TGF-beta/Smad 信号通路 >> PKC
  信号通路 >> 干细胞及 Wnt 通路 >> ERK
• 靶点实验:

  ERK2

  ERK1

  PKCβII

• 体外研究: 192毫升抑制 10μM L-α溶血磷脂酰肌醇 (LPI)或 1μM毫升186诱导的 β-arrestin转运,国际50值分别为0.70微米、0.29微米[1]192毫升显著抑制表达 全球定位系统的 U2OS公司细胞中 ERK1/2的磷酸化[1]。 ML192(0,10,30和 100µM)减弱了野生型 GPR55型受体细胞中的 PKCβII易位[1]。
• 参考文献:

  [1]. Kotsikorou E, et al. Identification of the GPR55 antagonist binding site using a novel set of high-potency GPR55 selective ligands. Biochemistry. 2013 Dec 31;52(52):9456-69.

ML192物理化学性质

• 密度: 1.3±0.1 g/cm3
• 分子式: C₂₀H₂₂N₄O₂S
• 分子量: 382.479
• 精确质量: 382.146332
• LogP: 3.07
• InChIKey: GDPDARVUXXOYAJ-UHFFFAOYSA-N
• SMILES: Cc1nc(N2CCN(C(=O)c3ccco3)CC2)c2c3c(sc2n1)CCCC3
• 折射率: 1.664
• 储存条件: 2-8°C

ML192靶点实验

查看更多实验

实验名称：Primary cell-based high-throughput screening assay for identification of compounds th... 来源：Johns Hopkins Ion Channel Center 靶标：regulator of G-protein signaling 4 isoform 2 [Homo sapiens] External Id：JHICC_RGS_Act_HTS

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：uHTS identification of small molecule activators of the adaptive arm of the Unfolded ... 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

实验名称：Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu... 来源：NCGC External Id：CYP2D6395

实验名称：Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu... 来源：NCGC External Id：CYP2C9536

实验名称：High throughput fluorescence intensity-based biochemical assay to screen for small mo... 来源：University of Pittsburgh Molecular Library Screening Center 靶标：furin (paired basic amino acid cleaving enzyme), isoform CRA_a [Homo sapiens] External Id：MH080376 Biochemical HTS for Inhibitors of the Proprotein Convertase Furin.

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ML192英文别名

• 2-furanyl-[4-(2-methyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)-1-piperazinyl]methanone
• Furan-2-yl-[4-(2-methyl-5,6,7,8-tetrahydro-benzo[4,5]thieno[2,3-d]pyrimidin-4-yl)-piperazin-1-yl]-methanone
• ML-192
• 2-Furyl[4-(2-methyl-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-yl)-1-piperazinyl]methanone