纳洛酮结构式
|
常用名 | 纳洛酮 | 英文名 | Naloxone |
|---|---|---|---|---|
| CAS号 | 465-65-6 | 分子量 | 327.37 | |
| 密度 | 1.43 g/cm3 | 沸点 | 532.8ºC at 760 mmHg | |
| 分子式 | C19H21NO4 | 熔点 | 184ºC | |
| MSDS | N/A | 闪点 | 276.1ºC | |
| 符号 |
GHS02, GHS06, GHS08 |
信号词 | Danger |
纳洛酮用途Naloxone 是 Opioid receptor 的拮抗剂。Naloxone 可减轻阿片类药物过量引起的呼吸抑制。Naloxone 可能会引起肺水肿和心律失常。 |
| 中文名 | 纳洛酮 |
|---|---|
| 英文名 | naloxone |
| 中文别名 | (5alpha)-3,14-二羟基-17-丙-2-烯-1-基-4,5-环氧吗啡烷-6-酮 |
| 英文别名 | 更多 |
| 描述 | Naloxone 是 Opioid receptor 的拮抗剂。Naloxone 可减轻阿片类药物过量引起的呼吸抑制。Naloxone 可能会引起肺水肿和心律失常。 |
|---|---|
| 相关类别 | |
| 参考文献 |
| 密度 | 1.43 g/cm3 |
|---|---|
| 沸点 | 532.8ºC at 760 mmHg |
| 熔点 | 184ºC |
| 分子式 | C19H21NO4 |
| 分子量 | 327.37 |
| 闪点 | 276.1ºC |
| 精确质量 | 327.14700 |
| PSA | 70.00000 |
| LogP | 1.23930 |
| 外观性状 | 白色至略灰白色粉末 |
| 储存条件 | 2-8°C |
| 符号 |
GHS02, GHS06, GHS08 |
|---|---|
| 信号词 | Danger |
| 危害声明 | H225-H301 + H311 + H331-H370 |
| 警示性声明 | P210-P260-P280-P301 + P310-P311 |
| 危害码 (欧洲) | F,T |
| 风险声明 (欧洲) | 11-23/24/25-39/23/24/25 |
| 安全声明 (欧洲) | 7-16-36/37-45 |
| 危险品运输编码 | UN1230 - class 3 - PG 2 - Methanol, solution |
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Morphine-induced internalization of the L83I mutant of the rat μ-opioid receptor.
Br. J. Pharmacol. 172(2) , 593-605, (2014) Naturally occurring single-nucleotide polymorphisms (SNPs) within GPCRs can result in alterations in various pharmacological parameters. Understanding the regulation and function of endocytic traffick... |
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Sympathetic activity induced by naloxone-precipitated morphine withdrawal is blocked in genetically engineered mice lacking functional CRF1 receptor.
Toxicol. Appl. Pharmacol. 283(1) , 42-9, (2015) There is large body evidence indicating that stress can lead to cardiovascular disease. However, the exact brain areas and the mechanisms involved remain to be revealed. Here, we performed a series of... |
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Involvement of neurotransmitters in the action of the nociceptin/orphanin FQ peptide-receptor system on passive avoidance learning in rats.
Neurochem. Res. 39(8) , 1477-83, (2014) The nociceptin/orphanin FQ peptide (NOP) receptor and its endogenous ligand plays role in several physiologic functions of the central nervous system, including pain, locomotion, anxiety and depressio... |
| [14C]-Naloxone |
| [3H]-Naloxone |
| Narcanti |
| Nalone |
| Naloxonum |
| EN 1530 base |
| (4R,4aS,7aR,12bS)-4a,9-dihydroxy-3-prop-2-enyl-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7-one |
| Narcon |
| l-Naloxone |
| Narcan |
| n-Allylnoroxymorphone |
| Naloxona |
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