异欧前胡素

• 常用名: 异欧前胡素
• 英文名: Isoimperatorin
• CAS号: 482-45-1
• 分子量: 270.280
• 密度: 1.2±0.1 g/cm3
• 沸点: 448.3±45.0 °C at 760 mmHg
• 分子式: C₁₆H₁₄O₄
• 熔点: 109ºC
• 闪点: 224.9±28.7 °C

异欧前胡素用途

Isoimperatorin 是Angelica dahurica 根的甲醇提取物,有效抑制乙酰胆碱酯酶 (AChE),IC50 为 74.6 μM。

异欧前胡素名称

• 中文名: 异欧前胡素
• 英文名: isoimperatorin
• 中文别名: 4-(3-甲基丁-2-烯氧基)呋喃并[3,2-g]苯并吡喃-7-酮 | 4-(3-甲基丁-2-烯氧基)呋喃并[3,2-g]苯并吡喃-7-酮 | 白芷甲素

异欧前胡素生物活性

• 描述: Isoimperatorin 是Angelica dahurica 根的甲醇提取物,有效抑制乙酰胆碱酯酶 (AChE),IC50 为 74.6 μM。
• 相关类别:
  信号通路 >> 神经信号通路 >> 疼痛
  天然产物 >> 苯丙酸类
  研究领域 >> 神经疾病
• 靶点实验:

  IC50: 74.6 μM (AChE)[1]

• 体外研究: 在针对中草药新农药的筛选计划中,发现羌活根茎的乙醇提取物对两种线虫,松材线虫和南方根结线虫具有强烈的杀线虫活性。基于生物活性引导的分级分离,从乙醇提取物中分离出四种成分,并鉴定为Columbianetin,Falcarindiol,Falcarinol和Isoimperatorin。异欧前胡素对B. xylophilus的LC50值为21.83μg/ mL。当使用15分钟的紫外线光照处理时,镰刀菌醇,镰刀菌素和异欧前胡素对南方根结线虫的毒性几乎是黑暗处理的5倍,而哥伦比亚的毒性仅为毒性的2倍。已经证明异欧前胡素具有对几种昆虫的杀虫活性,如卷心菜蚜虫(Brevicoryne brassicae)[2]。在白芷(AD)提取物的活性部分中鉴定出异欧前胡素[3]。异欧前胡素通常用作内标(IS)[4]。
• 参考文献:

  [1]. Kim DK, et al. Acetylcholinesterase inhibitors from the roots of Angelica dahurica. Arch Pharm Res. 2002 Dec;25(6):856-9.

  [2]. Liu G, et al. Identification of Nematicidal Constituents of Notopterygium incisum Rhizomes against Bursaphelenchus xylophilus and Meloidogyne incognita. Molecules. 2016 Sep 23;21(10). pii: E1276.

  [3]. Park EY, et al. Angelica dahurica Extracts Improve Glucose Tolerance through the Activation of GPR119. PLoS One. 2016 Jul 8;11(7):e0158796.

  [4]. Yu XA, et al. The pharmacokinetics, bioavailability and excretion of bergapten after oral and intravenous administration in rats using high performance liquid chromatography with fluorescence detection. Chem Cent J. 2016 Oct 14;10:62.

异欧前胡素物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 448.3±45.0 °C at 760 mmHg
• 熔点: 109ºC
• 分子式: C₁₆H₁₄O₄
• 分子量: 270.280
• 闪点: 224.9±28.7 °C
• 精确质量: 270.089203
• PSA: 52.58000
• LogP: 3.88
• InChIKey: IGWDEVSBEKYORK-UHFFFAOYSA-N
• SMILES: CC(C)=CCOc1c2ccoc2cc2oc(=O)ccc12
• 外观性状: 白色粉末
• 蒸汽压: 0.0±1.1 mmHg at 25°C
• 折射率: 1.606
• 储存条件: -20°C Freezer

异欧前胡素安全信息

• 危险品运输编码: NONH for all modes of transport
• RTECS号: LV1513000

异欧前胡素靶点实验

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异欧前胡素英文别名

• IisoiMperatorin
• buten-1-yl)oxy]
• Iso Imperatorin
• Isoimperatoin
• MFCD00272155
• 4-[(3-Methyl-2-buten-1-yl)oxy]-7H-furo[3,2-g]chromen-7-one
• Isoimperatorin
• 4-PRENYLOXYPSORALEN
• Isomperatorin
• Auraptin
• isoimperatonin
• 4-[(3-Methylbut-2-en-1-yl)oxy]-7H-furo[3,2-g]chromen-7-one
• Cnidin