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异欧前胡素

异欧前胡素用途

异欧前胡素具有降压、解痉、抗癌的作用，还可以治疗银屑病。
用于含量测定、鉴定、药理实验等。

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异欧前胡素名称

[ CAS 号 ]:
482-45-1

[ 中文名 ]:
异欧前胡素

[ 英文名 ]:
Isoimperatorin

[中文别名 ]:

白芷甲素

[英文别名 ]:

IisoiMperatorin
buten-1-yl)oxy]
Iso Imperatorin
Isoimperatoin
MFCD00272155
Isoimperatorin
4-PRENYLOXYPSORALEN
Isomperatorin
Auraptin
isoimperatonin

异欧前胡素生物活性

[ 描述 ]:

Isoimperatorin 是Angelica dahurica 根的甲醇提取物,有效抑制乙酰胆碱酯酶 (AChE),IC50 为 74.6 μM。

[ 相关类别 ]:

信号通路 >> 神经信号通路 >> 疼痛

天然产物 >> 苯丙酸类

研究领域 >> 神经疾病

[ 靶点 ]

IC50: 74.6 μM (AChE)[1]

[体外研究]

在针对中草药新农药的筛选计划中,发现羌活根茎的乙醇提取物对两种线虫,松材线虫和南方根结线虫具有强烈的杀线虫活性。基于生物活性引导的分级分离,从乙醇提取物中分离出四种成分,并鉴定为Columbianetin,Falcarindiol,Falcarinol和Isoimperatorin。异欧前胡素对B. xylophilus的LC50值为21.83μg/ mL。当使用15分钟的紫外线光照处理时,镰刀菌醇,镰刀菌素和异欧前胡素对南方根结线虫的毒性几乎是黑暗处理的5倍,而哥伦比亚的毒性仅为毒性的2倍。已经证明异欧前胡素具有对几种昆虫的杀虫活性,如卷心菜蚜虫(Brevicoryne brassicae)[2]。在白芷(AD)提取物的活性部分中鉴定出异欧前胡素[3]。异欧前胡素通常用作内标(IS)[4]。

[参考文献]

[1]. Kim DK, et al. Acetylcholinesterase inhibitors from the roots of Angelica dahurica. Arch Pharm Res. 2002 Dec;25(6):856-9.

[2]. Liu G, et al. Identification of Nematicidal Constituents of Notopterygium incisum Rhizomes against Bursaphelenchus xylophilus and Meloidogyne incognita. Molecules. 2016 Sep 23;21(10). pii: E1276.

[3]. Park EY, et al. Angelica dahurica Extracts Improve Glucose Tolerance through the Activation of GPR119. PLoS One. 2016 Jul 8;11(7):e0158796.

[4]. Yu XA, et al. The pharmacokinetics, bioavailability and excretion of bergapten after oral and intravenous administration in rats using high performance liquid chromatography with fluorescence detection. Chem Cent J. 2016 Oct 14;10:62.

[相关活性小分子]

异欧前胡素物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
448.3±45.0 °C at 760 mmHg

[ 熔点 ]:
109ºC

[ 分子式 ]:
C₁₆H₁₄O₄

[ 分子量 ]:
270.280

[ 闪点 ]:
224.9±28.7 °C

[ 精确质量 ]:
270.089203

[ PSA ]:
52.58000

[ LogP ]:
3.88

[ 外观性状 ]:
白色粉末

[ 蒸汽压 ]:
0.0±1.1 mmHg at 25°C

[ 折射率 ]:
1.606

[ 储存条件 ]:
-20°C Freezer

异欧前胡素安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
LV1513000

异欧前胡素合成路线

详细合成路线

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异欧前胡素文献

In vitro activity of isoimperatorin, alone and in combination, against Mycobacterium tuberculosis.

Lett. Appl. Microbiol. 58(4) , 344-9, (2014)

Previous studies have shown that isoimperatorin (IO), a furanocoumarin isolated from several medicinal plants, has antimycobacterial activity against Mycobacterium tuberculosis strain H37Rv (ATCC 2729...

Study on pharmacokinetics and tissue distribution of pteryxin in mice by ultra-pressure liquid chromatography with tandem mass spectrometry.

Biomed. Chromatogr. 26(7) , 802-7, (2012)

Pteryxin is a coumarin compound naturally occurring in the roots of Radix Peucedani, a commonly used as traditional Chinese medicine for the treatment of certain respiratory diseases and hypertension....

Ethyl acetate extract from Angelica Dahuricae Radix inhibits lipopolysaccharide-induced production of nitric oxide, prostaglandin E2 and tumor necrosis factor-alphavia mitogen-activated protein kinases and nuclear factor-kappaB in macrophages.

Pharmacol. Res. 55(4) , 263-70, (2007)

Angelica dahurica (Umbelliferae) has been used to treat headache of common cold, supraorbital neuralgia, painful swelling on the body, nasal stuffiness, leukorrhea and arthralgia due to wind-dampness ...

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