氧化前胡素

• 常用名: 氧化前胡素
• 英文名: Oxypeucedanin
• CAS号: 737-52-0
• 分子量: 286.279
• 密度: 1.4±0.1 g/cm3
• 沸点: 469.6±45.0 °C at 760 mmHg
• 分子式: C₁₆H₁₄O₅
• 熔点: 141-142 °C
• 闪点: 237.8±28.7 °C

氧化前胡素用途

Oxypeucedanin 是从 Angelica dahurica 中分离出来的呋喃香豆素衍生物。Oxypeucedanin 是一种选择性的开放通道阻滞剂,可抑制 hKv1.5 通道电流,IC50 值为 76 nM。Oxypeucedanin 延长心脏动作电位持续时间 (APD),是一种潜在的抗心律失常试剂。Oxypeucedanin 通过抑制癌细胞迁移来诱导细胞凋亡 (apoptosis )。

氧化前胡素名称

• 中文名: 氧化前胡素
• 英文名: oxypeucedanin
• 中文别名: 淫羊藿素

氧化前胡素生物活性

• 描述: Oxypeucedanin 是从 Angelica dahurica 中分离出来的呋喃香豆素衍生物。Oxypeucedanin 是一种选择性的开放通道阻滞剂,可抑制 hKv1.5 通道电流,IC50 值为 76 nM。Oxypeucedanin 延长心脏动作电位持续时间 (APD),是一种潜在的抗心律失常试剂。Oxypeucedanin 通过抑制癌细胞迁移来诱导细胞凋亡 (apoptosis )。
• 相关类别:
  研究领域 >> 癌症
  研究领域 >> 心血管疾病
  信号通路 >> 跨膜转运 >> 钾通道
• 靶点实验:

  IC50: HKv1.5 current; apoptosis[1]

• 参考文献:

  [1]. Eun JS, et al. Effects of oxypeucedanin on hKv1.5 and action potential duration.Biol Pharm Bull. 2005 Apr;28(4):657-60.

  [2]. Yu Liu, et al. Oxypeucedanin hydrate monoacetate isolated from Angelica dahurica induces apoptosis in Caco-2 colon carcinoma cells through the mediation of PI3K-signalling pathway and inhibition of cancer cell migration

氧化前胡素物理化学性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 469.6±45.0 °C at 760 mmHg
• 熔点: 141-142 °C
• 分子式: C₁₆H₁₄O₅
• 分子量: 286.279
• 闪点: 237.8±28.7 °C
• 精确质量: 286.084137
• PSA: 65.11000
• LogP: 2.17
• InChIKey: QTAGQHZOLRFCBU-UHFFFAOYSA-N
• SMILES: CC1(C)OC1COc1c2ccoc2cc2oc(=O)ccc12
• 蒸汽压: 0.0±1.2 mmHg at 25°C
• 折射率: 1.634
• 储存条件: 2-8°C

氧化前胡素安全信息

• 危害码 (欧洲): Xi

氧化前胡素靶点实验

查看更多实验

实验名称：Antiproliferative activity against serum-stimulated primary rat aortic VSMC at 30 uM ... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL1817331

实验名称：Antioxidant activity assessed as inhibition of ferrous chloride-induced lipid peroxid... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4133602

实验名称：Inhibition of recombinant human CYP1A1 expressed in baker's yeast-derived microsomes ... 来源：ChEMBL 靶标：Cytochrome P450 1A1 External Id：CHEMBL4257963

实验名称：Inhibition of recombinant human BACE1 using Rh-EVNLDAEFK as substrate after 60 mins b... 来源：ChEMBL 靶标：Beta-secretase 1 External Id：CHEMBL1936881

实验名称：Antiausteritic activity against human MIAPaCa2 cells in nutrient-deprived medium meas... 来源：ChEMBL 靶标：MIA PaCa-2 External Id：CHEMBL4200159

实验名称：Antiausteritic activity against human PANC1 cells in nutrient-deprived medium measure... 来源：ChEMBL 靶标：PANC-1 External Id：CHEMBL4200158

实验名称：Larvicidal activity against Aedes aegypti larvae after 24 hrs by TLC bioassay 来源：ChEMBL 靶标：Aedes aegypti External Id：CHEMBL1013844

实验名称：Cytotoxicity against human PANC1 cells in DMEM measured after 24 hrs by WST8 assay 来源：ChEMBL 靶标：PANC-1 External Id：CHEMBL4200161

实验名称：Antifungal activity against Cladosporium cucumerinum assessed as inhibition of spore ... 来源：ChEMBL 靶标：Cladosporium cucumerinum External Id：CHEMBL1013843

实验名称：Antiausteritic activity against human PSN1 cells in nutrient-deprived medium measured... 来源：ChEMBL 靶标：PSN1 External Id：CHEMBL4200160

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氧化前胡素英文别名

• 4-(3,3-Dimethyl-oxiranylmethoxy)-furo[3,2-g]chromen-7-one
• 5-[(3,3-Dimethyl-2-oxiranyl)methoxy]-7H-furo[3,2-g]chromen-7-one
• 4-[(3,3-Dimethyl-2-oxiranyl)methoxy]-7H-furo[3,2-g]chromen-7-one
• Oxypencedanin
• 5-[(3,3-Dimethyloxiran-2-yl)methoxy]-7H-furo[3,2-g]chromen-7-one
• oxypeucadanin